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41.
Preparations of PbS-coated titanium dioxide (TiO2) and lead sulfide (PbS) nanoparticles under ultrasonic field at the multibubble sonoluminescence (MBSL) conditions were tested in water solutions. Under the optimal MBSL conditions (20 kHz and 220 W power input), PbS nanoparticles (diameter = 40-50 nm) were prepared by treating lead nitrate and thioacetamide for 20 min in water solutions. The size of PbS nanoparticles was found to be easily increased to about 90 nm in diameter by increasing the reactant concentration twice. A similar sonochemical reaction with TiO2 nanoparticles (about 20-30 nm in diameter) gave rise to PbS-coated TiO2 nanoparticles with a core/shell structure. The PbS thin film coating was quite uniform and the average coating depth of PbS on the TiO2 nanoparticles was about 2-3 nm under the described conditions. It is interesting to note that the coating depth was found to be controlled to 2-10 nm range by increasing the amounts of reactants for Pb and S twice with a sonication time of 30 min. 相似文献
42.
Haneul Lee Su Jin Kang Jimin Lee Kyong Hwa Park Won Jong Rhee 《International journal of molecular sciences》2022,23(13)
Prostate cancer (PCa) is the most commonly diagnosed malignancy among men in developed countries. The five-year survival rate for men diagnosed with early-stage PCa is approximately 100%, while it is less than 30% for castration-resistant PCa (CRPC). Currently, the detection of prostate-specific antigens as biomarkers for the prognosis of CRPC is criticized because of its low accuracy, high invasiveness, and high false-positive rate. Therefore, it is important to identify new biomarkers for prediction of CRPC progression. Extracellular vesicles (EVs) derived from tumors have been highlighted as potential markers for cancer diagnosis and prognosis. Specifically, urinary EVs directly reflect changes in the pathophysiological conditions of the urogenital system because it is exposed to prostatic secretions. Thus, detecting biomarkers in urinary EVs provides a promising approach for performing an accurate and non-invasive liquid biopsy for CPRC. In this study, we effectively isolated urinary EVs with low protein impurities using size-exclusion chromatography combined with ultrafiltration. After EV isolation and characterization, we evaluated the miRNAs in urinary EVs from healthy donors and patients with CRPC. The results indicated that miRNAs (miR-21-5p, miR-574-3p, and miR-6880-5p) could be used as potential biomarkers for the prognosis of CRPC. This analysis of urinary EVs contributes to the fast and convenient prognosis of diseases, including CRPC, in the clinical setting. 相似文献
43.
Eline A. M. Ruigrok Nicole S. Verkaik Erik de Blois Corrina de Ridder Debra Stuurman Stefan J. Roobol Dik C. Van Gent Marion de Jong Wytske M. Van Weerden Julie Nonnekens 《International journal of molecular sciences》2022,23(14)
Prostate specific membrane antigen targeted radionuclide therapy (PSMA-TRT) is a promising novel treatment for prostate cancer (PCa) patients. However, PSMA-TRT cannot be used for curative intent yet, thus additional research on how to improve the therapeutic efficacy is warranted. A potential way of achieving this, is combining TRT with poly ADP-ribosylation inhibitors (PARPi), which has shown promising results for TRT of neuroendocrine tumor cells. Currently, several clinical trials have been initiated for this combination for PCa, however so far, no evidence of synergism is available for PCa. Therefore, we evaluated the combination of PSMA-TRT with three classes of PARPi in preclinical PCa models. In vitro viability and survival assays were performed using PSMA-expressing PCa cell lines PC3-PIP and LNCaP to assess the effect of increasing concentrations of PARPi veliparib, olaparib or talazoparib in combination with PSMA-TRT compared to single PARPi treatment. Next, DNA damage analyses were performed by quantifying the number of DNA breaks by immunofluorescent stainings. Lastly, the potential of the combination treatments was studied in vivo in mice bearing PC3-PIP xenografts. Our results show that combining PSMA-TRT with PARPi did not synergistically affect the in vitro clonogenic survival or cell viability. DNA-damage analysis revealed only a significant increase in DNA breaks when combining PSMA-TRT with veliparib and not in the other combination treatments. Moreover, PSMA-TRT with PARPi treatment did not improve tumor control compared to PSMA-TRT monotherapy. Overall, the data presented do not support the assumption that combining PSMA-TRT with PARPi leads to a synergistic antitumor effect in PCa. These results underline that extensive preclinical research using various PCa models is imperative to validate the applicability of the combination strategy for PCa, as it is for other cancer types. 相似文献
44.
We performed numerical simulations of a 20 kT heavy explosion to predict the rise and diffusion of mushroom cloud after the atmospheric pressure is recover 相似文献
45.
In this paper, the threshold voltage instability characteristics of HfO2 high-k dielectric are discussed. The results from various stress bias conditions including DC and AC with variations of frequency, duty cycle, and polarity provide additional insights into the intrinsic behavior and the trapping dynamics of high-k materials. A reduced threshold voltage shift was observed at higher frequency and lower duty cycle under AC positive unipolar stress compared to DC stress. Similarly, the degradation of maximum transconductance was also reduced with AC stress. However, subthreshold swing changes were found to be negligible and fairly independent of stress frequencies and duty cycles under AC positive unipolar stress.When different polarity of stress, such as positive, negative, and bipolar stress was applied, it was observed that frequency and duty cycle dependencies were still valid in all three conditions. In contrast to positive stress, negative stress showed a decrease in the threshold voltage shift. Bipolar stress resulted in the highest threshold voltage instability, but the degradation in transconductance and subthreshold swing was actually smaller than those in negative unipolar stress. The bulk trap of HfO2 dielectric, which is proportional to its physical thickness, is believed to be the primary factor for threshold voltage shift. AC unipolar operation would allow a higher 10-year lifetime operating voltage than the DC condition. In addition to experimental results, a plausible mechanism has been proposed. 相似文献
46.
Diederik Verkest Julio Leao Da Silva Jr. Chantal Ykman Kris Croes Miguel Miranda Sven Wuytack Francky Catthoor Gjalt De Jong Hugo De Man 《The Journal of VLSI Signal Processing》1999,21(3):185-194
MATISSE is a design environment intended for developing systems characterized by a tight interaction between control and data-flow behavior, intensive data storage and transfer, and stringent real-time requirements. Matisse bridges the gap from a system specification, using a concurrent object-oriented language, to an optimized embedded single-chip hardware/software implementation. Matisse supports stepwise exploration and refinement of dynamic memory management, memory architecture exploration, and gradual incorporation of timing constraints before going to traditional tools for hardware synthesis, software compilation, and inter-processor communication synthesis. With this approach, specifications of embedded systems can be written in a high-level programming language using data abstraction. Application of MATISSE on telecom protocol processing systems in the ATM area shows significant improvements in area usage and power consumption. 相似文献
47.
Jong Duk Lee Sung Hun Jin Byung Chang Shim Byung-Gook Park 《Electron Device Letters, IEEE》2001,22(4):173-175
A novel process utilizing electrical stress is proposed for the formation of Co silicide on single crystal silicon (c-Si) FEAs to improve the field emission characteristics. Co silicide FEAs formed by electrical stress (ES) exhibited a significant improvement in turn-on voltage and emission current compared with c-Si FEAs. The improvement mainly comes from the lower effective work function of Co silicide and less blunting of tips during silicidation by electrical stress in an ultra high vacuum (UHV) environment less than 10-8 torr 相似文献
48.
Unlu M.S. Strite S. Won T. Adomi K. Chen J. Mohammad S.N. Biswas D. Morkoc H. 《Electronics letters》1989,25(20):1359-1360
Reports the nearly ideal electrical characteristics of p-Ge/N-GaAs heterojunction diodes grown by molecular beam epitaxy. The temperature and device size dependencies of the current-voltage characteristics have been investigated. At room temperature, unity ideality factor has been demonstrated over almost six decades of current.<> 相似文献
49.
Neural networks for associative memory based on the Hopfield relaxation model and matched filtering techniques with higher-order nonlinearity are proposed. These high-order models show dramatic improvement in memory storage capacity and error-correction capability in comparison to conventional binary autoassociative models 相似文献
50.
So Yoon Ahn Dong Kyung Sung Yun Sil Chang Won Soon Park 《International journal of molecular sciences》2022,23(12)
We attempted to determine whether intratracheal (IT) transplantation of mesenchymal stem cells (MSCs) could simultaneously attenuate hyperoxia-induced lung injuries and microbial dysbiosis of the lungs, brain, and gut in newborn rats. Newborn rats were exposed to hyperoxia (90% oxygen) for 14 days. Human umbilical cord blood-derived MSCs (5 × 105) were transplanted via the IT route on postnatal day (P) five. At P14, the lungs were harvested for histological, biochemical, and microbiome analyses. Bacterial 16S ribosomal RNA genes from the lungs, brain, and large intestine were amplified, pyrosequenced, and analyzed. IT transplantation of MSCs simultaneously attenuated hyperoxia-induced lung inflammation and the ensuing injuries, as well as the dysbiosis of the lungs, brain, and gut. In correlation analyses, lung interleukin-6 (IL-6) levels were significantly positively correlated with the abundance of Proteobacteria in the lungs, brain, and gut, and it was significantly inversely correlated with the abundance of Firmicutes in the gut and lungs and that of Bacteroidetes in the lungs. In conclusion, microbial dysbiosis in the lungs, brain, and gut does not cause but is caused by hyperoxic lung inflammation and ensuing injuries, and IT transplantation of MSCs attenuates dysbiosis in the lungs, brain, and gut, primarily by their anti-oxidative and anti-inflammatory effects. 相似文献