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31.
Biomolecular regulatory networks are organised around hubs, which can interact with a large number of targets. These targets compete with each other for access to their common hubs, but whether the effect of this competition would be significant in magnitude and in function is not clear. In this review, the authors discuss recent in vivo studies that analysed the system level retroactive effects induced by target competition in microRNA and mitogen‐activated protein kinase regulatory networks. The results of these studies suggest that downstream targets can regulate the overall state of their upstream regulators, and thus cannot be ignored in analysing biomolecular networks.Inspec keywords: reviews, RNA, molecular biophysics, enzymesOther keywords: target‐mediated reverse signalling, mitogen‐activated protein kinase regulatory networks, biomolecular regulatory networks, microRNA regulatory networks, review, in vivo study 相似文献
32.
Ji Chan Park Shin Wook Kang Jeong-Chul Kim Jae In Kwon Sanha Jang Geun Bae Rhim Mijong Kim Dong Hyun Chun Ho-Tae Lee Heon Jung Hyunjoon Song Jung-II Yang 《Nano Research》2017,(3):1044-1055
A cobalt-silica hybrid nanocatalyst bearing small cobalt particles of diameter ~5 nm was prepared through a hydrothermal reaction and hydrogen reduction.The resulting material showed very high CO conversion (>82%) and high hydrocarbon productivity (~1.0 gHc·g-1cat,·h-11) with high activity (~8.5 x 10-5 molco·g-1Co·S-1) in the Fischer-Tropsch synthesis reaction. 相似文献
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Kyung Seob Lim Jun-Kyu Park Myung Ho Jeong Jae-Woon Nah Dae Sung Park Jong Min Kim Jung Ha Kim So Youn Lee Eun Jae Jang Suyoung Jang Hyun Kuk Kim Doo Sun Sim Keun-Ho Park Young Joon Hong Youngkeun Ahn Jung Chaee Kang 《Journal of materials science. Materials in medicine》2016,27(4):66
The aim of this study was to evaluate antiproliferative sirolimus- and antioxidative alpha-lipoic acid (ALA)-eluting stents using biodegradable polymer [poly-l-lactic acid (PLA)] in a porcine coronary overstretch restenosis model. Forty coronary arteries of 20 pigs were randomized into four groups in which the coronary arteries had a bare metal stent (BMS, n = 10), ALA-eluting stent with PLA (AES, n = 10), sirolimus-eluting stent with PLA (SES, n = 10), or sirolimus- and ALA-eluting stent with PLA (SAS, n = 10). A histopathological analysis was performed 28 days after the stenting. The ALA and sirolimus released slowly over 30 days. There were no significant differences between groups in the injury or inflammation score; however, there were significant differences in the percent area of stenosis (56.2 ± 11.78 % in BMS vs. 51.5 ± 12.20 % in AES vs. 34.7 ± 7.23 % in SES vs. 28.7 ± 7.30 % in SAS, P < 0.0001) and fibrin score [1.0 (range 1.0–1.0) in BMS vs. 1.0 (range 1.0–1.0) in AES vs. 2.0 (range 2.0–2.0) in SES vs. 2.0 (range 2.0–2.0) in SAS, P < 0.0001] between the four groups. The percent area of stenosis based on micro-computed tomography corresponded with the restenosis rates based on histopathological stenosis in different proportions in the four groups (54.8 ± 7.88 % in BMS vs. 50.4 ± 14.87 % in AES vs. 34.5 ± 7.22 % in SES vs. 28.9 ± 7.22 % in SAS, P < 0.05). SAS showed a better neointimal inhibitory effect than BMS, AES, and SES at 1 month after stenting in a porcine coronary restenosis model. Therefore, SAS with PLA can be a useful drug combination for coronary stent coating to suppress neointimal hyperplasia. 相似文献
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Kim Kihyeun Son Myungwoo Pak Yusin Chee Sang-Soo Auxilia Francis Malar Lee Byung-Kee Lee Sungeun Kang Sun Kil Lee Chaedeok Lee Jeong Soo Kim Ki Kang Jang Yun Hee Lee Byoung Hun Jung Gun-Young Ham Moon-Ho 《Nano Research》2018,11(7):3957-3957
Nano Research - The order of the authors in the original version of this article was unfortunately incorrect on the first page and the first page of the ESM. Instead of Myungwoo Son1, Yusin Pak1,... 相似文献
37.
Kien Tiek Wong Boris Brigljević Jeong Hyeon Lee So Yeon Yoon Seok Byum Jang Choe Earn Choong Inwook Nah Hyeongjun Kim Hyun-Seog Roh Sang Kyu Kwak Hankwon Lim Min Jang 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(1):2204336
This study focuses on the applicability of single-atom Mo-doped graphitic carbon nitride (GCN) nanosheets which are specifically engineered with high surface area (exfoliated GCN), NH2 rich edges, and maximum utilization of isolated atomic Mo for propylene carbonate (PC) production through CO2 cycloaddition of propylene oxide (PO). Various operational parameters are optimized, for example, temperature (130 °C), pressure (20 bar), catalyst (Mo2GCN), and catalyst mass (0.1 g). Under optimal conditions, 2% Mo-doped GCN (Mo2GCN) has the highest catalytic performance, especially the turnover frequency (TOF) obtained, 36.4 h−1 is higher than most reported studies. DFT simulations prove the catalytic performance of Mo2GCN significantly decreases the activation energy barrier for PO ring-opening from 50–60 to 4.903 kcal mol−1. Coexistence of Lewis acid/base group improves the CO2 cycloaddition performance by the formation of coordination bond between electron-deficient Mo atom with O atom of PO, while NH2 surface group disrupts the stability of CO2 bond by donating electrons into its low-level empty orbital. Steady-state process simulation of the industrial-scale consumes 4.4 ton h−1 of CO2 with PC production of 10.2 ton h−1. Techno-economic assessment profit from Mo2GCN is estimated to be 60.39 million USD year−1 at a catalyst loss rate of 0.01 wt% h−1. 相似文献
38.
AUTOSAR是汽车开放系统体系结构,已成为汽车电子软件的工业标准,在汽车电子控制器系统开发过程中具有重要地位,其中AUTOSAR COM通信规范为汽车电子通信系统的构建提供了依据和参考;介绍了AUTOSAR体系架构,对AUTOSAR COM规范基于信号的通信机制及其特有的传输模式切换系统进行了研究,并实现了一种基于AUTOSAR架构的通信系统,试验结果表明该系统能够提供基本通信服务,且符合AUTOSAR COM规范。 相似文献
39.
Keunchang Jang Jeachul Kim Taehee Kim Ryuichi Hirata 《Remote sensing of environment》2010,114(3):657-673
Evapotranspiration (ET), the sum of evaporation from soil and transpiration from vegetation, is of vital importance in the hydrologic cycle and must be taken into consideration in assessments of the water resources of any region. The MODerate resolution Imaging Spectroradiometer (MODIS) sensor offers a promising opportunity for estimating daily ET with a 1 km spatial resolution, but is hampered by frequent cloud contamination or data gaps from other factors. In this study, 1) a stand-alone ET model was applied and tested during clear or partial cloudy sky conditions using MODIS-based inputs of land surface and atmospheric data and 2) meteorological simulations by using Four-Dimensional Data Assimilation (FDDA) system between MODIS and the 5th Generation Meso-scale Meteorological Model (MM5) was used in cloudy conditions to facilitate continuous daily ET estimates. The MODIS ET algorithm modified from Mu et al. (2007) is based on the Penman-Monteith equation and was applied to predict ET at flux measurement sites. This algorithm considers both the effects of surface energy partitioning processes and environmental constraints on ET. We devised gap-filling approaches for MODIS aerosol and albedo data that were identified as bottlenecks to determine retrieval rates of insolation and ET. MODIS-derived input variables (i.e., meteorological variables and radiation components) for estimating ET showed a good agreement with flux tower observations at each site. The retrieval rate of MODIS ET doubled at four flux measurement sites after gap-filling with negligible compensation was undertaken for accuracy. In spite of the high accuracy of MODIS-derived input variables, MODIS ET showed meaningful errors at the four flux measurement sites. These errors were mainly associated with errors in the estimated canopy conductance. During clear sky conditions, MODIS was used to calculate ET, while the MODIS-MM5 FDDA system provided input variables for the calculation of ET under cloudy sky conditions. The performance of the MODIS-MM5 FDDA system was evaluated by comparing ET based on MODIS, which showed a good agreement with the MODIS ET for various land cover types. Our results indicate that MODIS can be applied to monitor the land surface energy budget and ET with reasonable accuracy and that MODIS-MM5 FDDA has the potential to provide reasonable input data of ET estimation under cloudy conditions. 相似文献
40.
Yong‐Kyu Jang Seong Jun Lee Jae Young Lee Yi Li Jae Hoon Hwang Sang Woo Kim Chang Woo Shim Ju Yeon Seo Nam Jin Kim Yi Joon Ahn Nam Hee Kim Seon Hong Ahn Seong Ryong Lee Dae Hee Park Chi Woo Kim 《Journal of the Society for Information Display》2011,19(3):253-257
Abstract— A novel pixel design for vertical‐alignment LCDs with superior transmittance has been developed. The new liquid‐crystal mode, refered to as the hole‐induced vertical‐alignment mode (Hi‐VA), uses a via hole of an organic layer on a TFT substrate to achieve multi‐domain alignment. Compared to the conventional design, the Hi‐VA mode has a transmittance of up to 135% with a contrast ratio of 2000:1. Moreover, the new structure is free from ITO patterning or protrusion on the color‐filter side, which makes the fabrication process simple and low cost. 相似文献