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31.
Katharina Strohmeier Sigurd Schober Martin Mittelbach 《Journal of the American Oil Chemists' Society》2014,91(7):1217-1224
An easy and efficient method for the separation of saturated and unsaturated fatty acid mono alkyl esters, prepared from animal fat, was developed. The most efficient separation was achieved by the use of solvents such as methanol and acetone at low temperatures. The dilution of the alkyl esters with 10 times the amount of solvent (10:1 v/w) and storage of the mixture for 4 h at ?22 °C could be defined as optimum conditions. After filtration of the saturated fraction at the corresponding temperature very pure fractions were obtained. For fatty acid methyl esters deriving from tallow, with an initial content of saturated fatty acids of almost 50 %, a saturated ester fraction with only 5 % unsaturated fatty acids and an unsaturated ester fraction with about 9 % of saturated fatty acids could be obtained. The solvent easily could be recovered by distillation. In addition fatty acid ethyl, 1‐propyl, 2‐propyl, 1‐butyl, tert‐butyl and 3‐methyl‐1‐butyl esters were prepared and separated into saturated and unsaturated fractions. All fractions were analyzed according to the fatty acid compositions and showed similar or slightly worse results compared to the methyl esters. The cold filter plugging points of the unsaturated fractions were measured, showing the lowest value for the unsaturated methyl ester fraction at ?26 °C. The fractionation with the use of solvents is an easy tool in order to obtain fatty acid alkyl esters with excellent cold temperature behavior out of animal fat. 相似文献
32.
Titanium dioxide nanoparticles are precisely segregated in or on polymer submicron particles domains by phase separation between a polymer and a hydrophobic liquid or between two different polymers. The inorganic nanoparticles can be located either in the core, as a patch on the surface of the polymer particle, as a disk, or in the middle of Janus polymer particles. In the latter case, tricompartment submicron particles arranged in a linear triblock fashion are fabricated. 相似文献
33.
Dominic Riedel Thomas Wurm Katharina Graf Matthias Rudolph Frank Rominger A. Stephen K. Hashmi 《Advanced Synthesis \u0026amp; Catalysis》2015,357(7):1515-1523
In a modular template synthesis, unsaturated NHC complexes of gold, palladium and platinum were synthesized from simple metal salts, isonitriles and amines with acetal or ketal groups. Upon the addition of amines with tethered acetal or ketal moieties to the metal‐activated isonitrile, first nitrogen acyclic carbene (NAC) complexes are formed. These undergo ring closure and elimination to the unsaturated NHC complexes upon addition of acid. This simple strategy opens an attractive and fast approach to NHC complexes of gold, palladium and platinum. The modular approach allows a fast modification and is well‐suited for the synthesis of unsymetrically and symmetrically substituted unsaturated NHC complexes.
34.
Ramiro Vilchez-Vargas Franz Salm Eva B. Znalesniak Katharina Haupenthal Denny Schanze Martin Zenker Alexander Link Werner Hoffmann 《International journal of molecular sciences》2022,23(3)
Here, the spatial distribution of the bacterial flora along the murine alimentary tract was evaluated using high throughput sequencing in wild-type and Tff3-deficient (Tff3KO) animals. Loss of Tff3 was linked to increased dextran sodium sulfate-induced colitis. This systematic study shows the results of 13 different regions from the esophagus to the rectum. The number of bacterial species (richness) increased from the esophagus to the rectum, from 50 to 200, respectively. Additionally, the bacterial community structure changed continuously; the highest changes were between the upper/middle and lower gastrointestinal compartments when comparing adjacent regions. Lactobacillus was the major colonizer in the upper/middle gastrointestinal tract, especially in the esophagus and stomach. From the caecum, a drastic diminution of Lactobacillus occurred, while members of Lachnospiraceae significantly increased. A significant change occurred in the bacterial community between the ascending and the transverse colon with Bacteroidetes being the major colonizers with relative constant abundance until the rectum. Interestingly, wild-type and Tff3KO animals did not show significant differences in their bacterial communities, suggesting that Tff3 is not involved in alterations of intraluminal or adhesive microbiota but is obviously important for mucosal protection, e.g., of the sensitive stem cells in the colonic crypts probably by a mucus plume. 相似文献
35.
Leon Wehrhan Prof. Dr. Alexander Hillisch Dr. Stefan Mundt Dr. Adrian Tersteegen Dr. Katharina Meier 《ChemMedChem》2020,15(21):2010-2018
Target druggability assessment is an integral part of the early target characterization and selection process in pharmaceutical industry. Here, we investigate a set of five different serine proteases from the blood coagulation cascade. The aim of this study is twofold. Firstly, leveraging the wealth of available in-house high-throughput screening (HTS) data, we analyze HTS hit rates and discuss their predictive value for the development of small molecule (SMOL) candidates. Purely structure-activity relationship (SAR) based druggability ratings are compared with computational protein-structure based druggability assessments. Secondly, we evaluate the impact of using conformational ensembles from molecular dynamics (MD) simulations instead of single static crystal structures as basis for computational druggability assessments. Based on this study, we recommend incorporating molecular dynamics routinely into the early target characterization process, especially if only a single X-ray structure is available. 相似文献
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38.
Human Intelligence in the Process of Semantic Content Creation 总被引:1,自引:0,他引:1
Despite significant progress over the last years the large-scale adoption of semantic technologies is still to come. One of the reasons for this state of affairs is assumed to be the lack of useful semantic content, a prerequisite for almost every IT system or application using semantics. Through its very nature, this content can not be created fully automatically, but requires, to a certain degree, human contribution. The interest of Internet users in semantics, and in particular in creating semantic content, is, however, low. This is understandable if we think of several characteristics exposed by many of the most prominent semantic technologies, and the applications thereof. One of these characteristics is the high barrier of entry imposed. Interacting with semantic technologies today requires specific skills and expertise on subjects which are not part of the mainstream IT knowledge portfolio. A second characteristic are the incentives that are largely missing in the design of most semantic applications. The benefits of using machine-understandable content are in most applications fully decoupled from the effort of creating and maintaining this content. In other words, users do not have a motivation to contribute to the process. Initiatives in the areas of the Social Semantic Web acknowledged this problem, and identified mechanisms to motivate users to dedicate more of their time and resources to participate in the semantic content creation process. Still, even if incentives are theoretically in place, available human labor is limited and must only be used for those tasks that are heavily dependent on human intervention, and cannot be reliably automated. In this article, we concentrate on this step in between. As a first contribution, we analyze the process of semantic content creation in order to identify those tasks that are inherently human-driven. When building semantic applications involving these specific tasks, one has to install incentive schemes that are likely to encourage users to perform exactly these tasks that crucially rely on manual input. As a second contribution of the article, we propose incentives or incentive-driven tools that can be used to increase user interest in semantic content creation tasks. We hope that our findings will be adopted as recommendations for establishing a fundamentally new form of design of semantic applications by the semantic technologies community. 相似文献
39.
Photo‐crosslinking of poly[ethene‐stat‐(methacrylic acid)] functionalised with maleimide side groups
Nadine Schmeling Katharina Hunger Gernot Engler Benjamin Breiten Patrick Rölling Alexander Mixa Claudia Staudt Karl Kleinermanns 《Polymer International》2009,58(7):720-727
BACKGROUND: Photo‐crosslinkable polymers are well known and commercially applied as photoresists. But so far they have not been applied as membrane materials for separation processes. They would offer certain advantages in membrane fabrication over conventional crosslinked polymer materials. Therefore, in this work, a poly[ethene‐stat‐(methacrylic acid)] (PEMAA) which is a potential membrane polymer for different separation problems was functionalised with photo‐crosslinkable maleimide side groups. RESULTS: It has been shown that PEMAA can be used as basic polymer material and a conversion with 3‐hydroxypropylmaleimide is possible in order to obtain a photo‐crosslinkable polymer. Investigation of the crosslinking mechanism was performed using stationary infrared and UV‐visible spectroscopy as well as nanosecond transient spectroscopy absorption measurements of a rotating film. Intense transient absorption of the maleimide‐esterified PEMAA occurs at 250 nm in the film pointing to maleimide anion formation and crosslinking via an ionic dimerisation mechanism. CONCLUSION: It is found that crosslinking reactions can be observed spectroscopically in situ using a maleimide‐functionalised PEMAA. Furthermore, experiments can be performed in the liquid phase (polymer in solution) as well as in the solid phase (polymer film) using a rotating polymer film sample. Maleimide anion formation and crosslinking via an ionic dimerisation mechanism can be investigated by variation of the polymer structure as well as the structure of the maleimide side groups. Copyright © 2009 Society of Chemical Industry 相似文献