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51.
Building a home and creating a family are highly interconnected processes. So what happens to the home when people separate or divorce? This paper addresses this question using both a quantitative and a qualitative approach. Based on an extensive database with socio-economic background data of 42 000 separated Danish couples in 2002, the housing careers of both partners were followed to see how the housing situation of different types of people was affected by the separation. In the qualitative approach, nine interviews with couples who had parted shed light on the emotions and practical problems of dissolving a home: how to decide who should stay? Who should move? What was it like to stay alone in, or to leave, the matrimonial home? 相似文献
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G. Sonntag C. A. Neufeld A. Kirsten C. Mai und Max Müller 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1904,7(5):315-319
Ohne Zusammenfassung 相似文献
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Hans Erhorn Tomasz Mroz Ove Mørck Fritz Schmidt Lorenz Schoff Kirsten Engelund Thomsen 《Energy and Buildings》2008,40(4):419-428
Educational buildings such as kindergartens, schools and universities display many similar design, operation and maintenance features in most countries. The two most noteworthy similarities amongst these building types are the high energy consumption and the necessity for retrofitting many buildings within this sector. However, studies have shown that during retrofit, energy saving measures are only rarely applied, because the decision-makers lack knowledge of investments and the efficiency of potential energy saving measures. The main goal of the International Energy Agency ECBCS Annex 36 is to provide the educational building decision-makers with sufficient data, information and tools to improve their learning and teaching environments by improving the energy efficiency of their buildings. 相似文献
55.
K. Bobzin T. Schläfer K. Richardt L. Zhao P. Kutschmann 《Materialwissenschaft und Werkstofftechnik》2008,39(12):867-870
Microstructure and properties of Fe‐based wire arc sprayed coatings Innovative iron based feedstocks for wire arc spraying are a promising alternative for conventional carbide reinforced feedstocks for wear applications. Recently the main area of research is focused on improving the properties of deposited functional coatings by varying the wire composition. The influence on the crystalline structure and the dimension of the hard phases in the resulting microstructure is of particular interest in this context. The objective of the investigation is to produce coatings with an amorphous phase, submicron and nanocrystalline structure. The forming of the amorphous phase is influenced by high cooling rates of the molten and partly molten particles impinging on the substrate. Thus, the achieved coatings are characterized by high hardness as well as high corrosion and wear resistance. The present paper introduces iron based coatings produced by wire arc spraying. Due to the application of cored wires with a modified alloy composition the forming of an amorphous phase as well as a submicron‐ and nanocrystalline structure is promoted. The filling of the cored wires are based on FeB with a eutectic composition and is varied by adding Cr3C2, FeSi, FeCrC and AlMg. The adding of further elements like Cr, C, Si, Al and Mg should improve the forming of the amorphous phase. The deposited coatings are analyzed regarding to the resulting coating properties and phase composition in connection with the composition of the cored wires. XRD‐analysis’ proved that the Fe‐based coatings contain an amorphous phase. 相似文献
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Max Müller A. Kirsten A. Heberand W. Roth C. Mci A. Kirsten und A. Oclker 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1904,7(2):90-111
Ohne Zusammenfassung 相似文献
60.
Dr. Kornelia Hardes Dr. Gero L. Becker Dr. Yinghui Lu Dr. Sven O. Dahms Susanne Köhler Dr. Wolfgang Beyer Prof. Kirsten Sandvig Dr. Hiroyuki Yamamoto Prof. Iris Lindberg Lisa Walz Dr. Veronika von Messling Dr. Manuel E. Than Prof. Wolfgang Garten Prof. Torsten Steinmetzer 《ChemMedChem》2015,10(7):1218-1231
New peptidomimetic furin inhibitors with unnatural amino acid residues in the P3 position were synthesized. The most potent compound 4‐guanidinomethyl‐phenylacteyl‐Arg‐Tle‐Arg‐4‐amidinobenzylamide (MI‐1148) inhibits furin with a Ki value of 5.5 pM . The derivatives also strongly inhibit PC1/3, whereas PC2 is less affected. Selected inhibitors were tested in cell culture for antibacterial and antiviral activity against infectious agents known to be dependent on furin activity. A significant protective effect against anthrax and diphtheria toxin was observed in the presence of the furin inhibitors. Furthermore, the spread of the highly pathogenic H5N1 and H7N1 avian influenza viruses and propagation of canine distemper virus was strongly inhibited. Inhibitor MI‐1148 was crystallized in complex with human furin. Its N‐terminal guanidinomethyl group in the para position of the P5 phenyl ring occupies the same position as that found previously for a structurally related inhibitor containing this substitution in the meta position, thereby maintaining all of the important P5 interactions. Our results confirm that the inhibition of furin is a promising strategy for a short‐term treatment of acute infectious diseases. 相似文献