Fractal fracture and transformation toughening in CuNiAl single crystal

The fracture toughness J _Ic (ρ) and fractal dimension D _f of fractured surfaces of CuNiAl single crystal have been measured at temperatures in the range 20 °C to 120 °C, in which thermoelastic martensitic transformation takes place. The parent phase has higher fracture toughness than the martensite phase due to stress-induced transformation. The relationship between J _Ic (ρ) and D _f has been studied. It was found that log J _Ic (ρ) is linearly related to D _f if the failure involves a single mechanism. The slope of the plot may either be positive or negative for brittle or ductile failure, respectively. The difference in the J _Ic (ρ)-D _f correlation can be understood in terms of the micromechanism of fracture.     

A new approach to aid urban water management decision making using trade-off sacrifice modelled by fuzzy logic.

An approach to aid decision making for urban water management is presented that is based on the concept of trade-off sacrifice level in pairwise comparisons between criteria, modelled using fuzzy logic. This approach is illustrated by a case study - selection of alternative water supplies for a Sydney household. Four key decision making criteria covering health, economic, environment and technical aspects are selected: annual probability of infection, life cycle energy use, life cycle cost and reliability. The decision making problem is to select between cases with different volume and application of recycled greywater and rainwater in light of the four criteria. Decision maker's preference is expressed by five levels of trade-off sacrifice between pairs of criteria. The decision makers can assign their preferences for sacrifice level by linguistic assessment and the output trade-off weight (TOW). Measures of decision makers' perceived trade-off level are modelled by a rule-based fuzzy logic control system. The final analysis shows the performance for each sacrifice class for each case, to aid overall decision making with stakeholders.     

High-speed Modulation of InGaAs: Sb-GaAs-GaAsP quantum-well vertical-cavity surface-emitting lasers with 1.27-/spl mu/m emission wavelength

1.27-/spl mu/m InGaAs: Sb-GaAs-GaAsP vertical-cavity surface-emitting lasers (VCSELs) were grown by metal-organic chemical vapor deposition and exhibited excellent performance and temperature stability. The threshold current changes from 1.8 to 1.1 mA and the slope efficiency falls less than /spl sim/35% as the temperature raised from room temperature to 70/spl deg/C. With a bias current of only 5 mA, the 3-dB modulation frequency response was measured to be 8.36 GHz, which is appropriate for 10-Gb/s operation. The maximal bandwidth is measured to be 10.7 GHz with modulation current efficiency factor (MCEF) of /spl sim/5.25 GHz/(mA)/sup 1/2/. These VCSELs also demonstrate high-speed modulation up to 10 Gb/s from 25/spl deg/C to 70/spl deg/C.     

2005，十大危险入侵主妇厨房

食品安全．在2005年中仍然纷纷扰扰：食品与家庭每个成员的健康息息相关，而维护全家人的健康，则是女主人义不容辞的责任。我们一起来听听．于她们而言．2005年最关心的食品安全问题是什么？[编者按]     

Identification of spherical virus particles in digitized images of entire electron micrographs

Interferon-gamma (IFN-gamma) has the most potent immunomodulatory activity of all the interferons. This phase II-B study was performed to define time- and dose-dependent immunomodulatory effects mediated by IFN-gamma in a subset of patients with melanoma treated in the dose-seeking therapeutic trial conducted by the Eastern Cooperative Oncology Group E4687 (13). The effects of IFN-gamma (Genentech, San Francisco, CA) were evaluated for phenotype and function of peripheral blood lymphocytes obtained twice prestudy, and on days 2, 9, and 29 of IFN-gamma therapy for 50 patients. Early significant increases in CD4/CD8 ratio (p = 0.001) were noted, largely due to a rise in CD4+ and fall in CD8+ T-cell populations sustained through day 29 at only the lowest dosage. Increased natural killer cell (NK) activity (p = 0.001 on day 9; p = 0.01 on day 29) was accompanied by durable increases in circulating activated NK cells (CD56+DR+% p = 0.001, day 9; p = 0.001, day 29). After initial depression of CD56+ and CD16+ cells on day 2, the total percent of CD56+ and CD16+ cells increased significantly by day 29. Increases in NK cell activity were maximal at doses > or =0.1 mg. Monocyte CD14+ expression of DQ+ rose early (p = 0.011 and 0.001 on days 2 and 9), accompanied by elevation in CD14+DR+ cells that was less significant. Immunomodulatory effects of IFN-gamma reported in this trial have major implications for interpretation of past and current clinical trials, and the design of future trials. This is the first trial in which IFN-gamma has been shown to have significant effects on the T-cell compartment of the immune system.     

Use of solid phase extraction disks for the GC-MS analysis of acidic and neutral herbicides in drinking water

An analytical procedure was developed in which thirteen herbicides (10 acidic and 3 neutral compounds) may be extracted from drinking water samples using solid phase extraction disks and subsequently analyzed by gas chromatography-mass spectrometry. Using 8 replicate samples consisting of reagent water fortified with nanogram quantities of each herbicide, the average percent recoveries and method detection limits were determined for each analyte. The method was found to be suitable for the determination of individual herbicides in drinking water at concentrations of approximately 10 ng/L.     

Rapid, sensitive procedure to determine buspirone levels in rat brains using gas chromatography with nitrogen-phosphorus detection

Reported here is a rapid, sensitive and relatively inexpensive procedure using gas chromatography with nitrogen-phosphorus detection (GC-NPD) to quantify buspirone levels in brains of rats. The analyte was directly extracted from brain homogenate with toluene after basification and then subjected to GC-NPD analysis using a capillary column. The calibration curves were linear over the range of 10 to 320 ng per 2 ml of brain homogenate, with typical r2 values >0.99. The assay was highly reproducible and gave peaks with excellent chromatographic properties.     

中国南海北部二氧化碳气成因

中国南海北部海域在油气勘探中发现了CO_2气,对油气有无影响?在借鉴世界、中国东部陆地CO_2气成因研究成果的基础上,从分析研究区CO_2,气的分布入手,采用多种方法,在综合分析基础上,对本区CO_2气藏进行分类.认为研究区CO_2;气藏为无机成因,其特征受各盆地或地区具体地质条件的控制.哈萨克斯坦引起了国际石油界的很大关注,但它并不是前苏联唯一的具吸引力之地.美国地质调查调查所(丹佛)和AAPG今年著名讲演者Gregory F Ulmishek说.前苏联有20多个沉积盆地生产油气或具有尚未开采的发现.Ulmishek 1980年到美国前,获得过莫斯科石油学院地质学硕士学位,作为一个地质学家在前苏联工作过23年.他的1993—1994年题为“前苏联主要油气地质学及勘探潜力”的著名演讲在1993年12月6日至17日和1994年3月28日至4月8日的巡回活动中推出.     

Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry

OBJECTIVE: To characterize changes of Th1/Th2 cytokine production by peripheral blood mononuclear cells (PBMC) that occur during the course of HIV infection by cytoplasmic cytokine staining on single cell level. DESIGN AND METHODS: Mitogen-stimulated PBMC from 16 healthy donors, 18 HIV-1-infected individuals without AIDS and 14 patients with AIDS were stained intracellularly with fluorescein-labelled MAb against interleukin (IL)-2, IL-4, IL-10 and interferon (IFN)-gamma. Additionally, co-staining of CD4+ T-cell, CD8+ T-cell, natural killer (NK) cell, B-cell and monocytic markers was performed. Fluorescence staining was analysed by three-colour flow-cytometry. RESULTS: A reduced percentage of IL-2 and IFN-gamma (Th1 type)-producing cells among CD4+ T cells from HIV-1-infected individuals could be demonstrated. There was a continuous decrease of IFN-gamma-producing CD4+ T cells in the course of HIV infection and a dramatic reduction of IL-2-expressing cells among CD4+ T cells in patients with AIDS. In contrast to Th1 cytokines, the frequency of Th2 cytokine expressing cells among CD4+ T cells increased in HIV-infected individuals. The maximum frequency of IL-4-expressing cells among CD4+ T cells was seen in HIV-infected individuals without AIDS, whereas the rate of IL-10-producing cells was highest in patients with AIDS. In HIV-infected individuals no significant proportion of Th0 cells expressing both Th1 and Th2 cytokines was detectable. In CD8+ T cells the percentage of IL-2 was expressing cells decreased continuously accompanied by a strong increase of the frequency of IFN-gamma-producing cells. CONCLUSION: The decreased percentage of cells expressing IL-2 and IFN-gamma in conjunction with an increased proportion of IL-4- and IL-10-producing cells among the CD4+ T cells in HIV-1-infected individuals demonstrate a Th1 to Th2 cytokine shift in the course of HIV infection on a single cell level. There was no evidence of a Th1 to Th0 cytokine shift. In addition to the loss of CD4+ T cells in HIV infection, the qualitative changes of Th1/Th2 cytokine expression may serve as a marker for progressive failure of cell-mediated immunity.