Self-Assembled Peptide-Based Nanodrugs: Molecular Design,Synthesis, Functionalization,and Targeted Tumor Bioimaging and Biotherapy

Functional nanomaterials as nanodrugs based on the self-assembly of inorganics, polymers, and biomolecules have showed wide applications in biomedicine and tissue engineering. Ascribing to the unique biological, chemical, and physical properties of peptide molecules, peptide is used as an excellent precursor material for the synthesis of functional nanodrugs for highly effective cancer therapy. Herein, recent progress on the design, synthesis, functional regulation, and cancer bioimaging and biotherapy of peptide-based nanodrugs is summarized. For this aim, first molecular design and controllable synthesis of peptide nanodrugs with 0D to 3D structures are presented, and then the functional customization strategies for peptide nanodrugs are presented. Then, the applications of peptide-based nanodrugs in bioimaging, chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) are demonstrated and discussed in detail. Furthermore, peptide-based drugs in preclinical, clinical trials, and approved are briefly described. Finally, the challenges and potential solutions are pointed out on addressing the questions of this promising research topic. This comprehensive review can guide the motif design and functional regulation of peptide nanomaterials for facile synthesis of nanodrugs, and further promote their practical applications for diagnostics and therapy of diseases.     

微生物采油技术物理模拟研究现状

针对国内外微生物采油技术的物理模拟研究现状,从微生物采油机理,微生物在多孔介质中的生长、代谢、运移、堵塞,微生物提高采收率等3个方面进行了分析和总结。对于微生物采油机理,主要介绍了微生物对原油的乳化-携带、剥离油膜、生物气以及界面局部富集等。微生物在地层孔隙中的生长是油藏微生物生态系统中竞争与协同双重作用的结果,而协同作用主要表现在营养的链式利用上,微生物在多孔介质中是倾向于运移通过还是倾向于吸附堵塞主要取决于有无相对静止的生长环境,处于随水流一起运移状态的微生物不易产生吸附和堵塞;无论是内源微生物还是外源微生物都可以产生显著的驱油效果,可提高采收率6%~15%。未来微生物采油技术的研究应加强在微生物驱油机理多因素的量化表达、有益菌的识别和选择性激活以及提高物理模拟研究手段与现场试验的相似性3个方向的研究。     

酵母提前絮凝的研究进展

介绍了国内外关于酵母提前絮凝的研究进展及导致酵母提前凝的因素和酵母提前絮凝的假说机理,归纳了酵母絮凝的检测方法,提出了预防酵母提前絮凝的措施及酵母提前絮凝的研究方向。     

Diltiazem concentrations in plasma vs PR intervals on electrocardiogram in 8 men

AIM: To develop an acute tolerant model in describing relationship between diltiazem (Dil) concentrations in plasma and PR intervals on ECG in men. METHOD: Both plasma concentrations of Dil and changes of ECG were simultaneously determined after po Dil 90 mg in 8 men. RESULTS: A two-compartmental pharmacokinetic model with first-order input gave a good fitting for the plasma concentration of Dil. Corresponding pharmacokinetic parameters were estimated: t1/2 beta, 5.9 +/- 1.0 h; MRT, 15.9 +/- 1.0 h; t0, 0.38 +/- 0.07 h; tmax, 2.7 +/- 0.4 h, and Cmax, 161 +/- 60 micrograms.L-1. The good fittings for plasma concentration-effect data were obtained with tolerant model E = S x C/(1 + T/T50). The pharmacodynamic parameters were given as follows: S, 829 +/- 293 s.g-1.L; Kt0, 0.037 +/- 0.024 h-1 and T50, 10 +/- 4 micrograms.L-1. CONCLUSION: Relationship between Dil concentrations in plasma and PR interval changes in men after po 90 mg was described using an acute tolerant model.     

西钢电弧炉节电实践

对影响电弧炉冶炼电耗的主要因素进行了理论分析,降低电弧炉冶炼电耗的基本途径是缩短冶炼周期。应用电弧炉热装铁水技术;优化了供电曲线;在50t交流电弧炉冶炼周期应用综合控制理论,冶炼电耗平均为290kWh/t。     

Effects of Indium Doping on the Properties of Cd1-xMnxTe Crystals

通过近红外和红外透过谱表征,确定出掺铟后碲锰镉晶体透过率迅速下降,这是晶格吸收和自由载流子吸收共同作用的结果;而光致发光谱的分析结果表明,掺杂后施主-受主对峰增加,受主束缚激子峰减弱,且随着In含量的增加,受主束缚激子峰消失,只剩下施主-受主对峰。这一系列变化是因为替代的In原子作为施主补偿了Cd空位的缘故。拉曼光谱的测量显示,In掺杂导致"类CdTe"的纵向光学声子峰减弱;而磁学的测试结果则说明In的引入几乎不引起碲锰镉晶体磁化强度的变化。     

苯加氢烷基化制环己基苯催化剂的制备与工艺条件的考察

采用等体积浸渍法制备了Ni-Cu/Hβ双功能催化剂,采用XRD、N2吸附-脱附、TEM和NH3-TPD方法对催化剂进行了表征,并将其用于催化苯加氢烷基化制备环己基苯的反应,考察了催化剂的制备条件(Ni负载量、Ni和Cu的来源、助催化剂的种类)和反应条件(反应时间、反应温度、氢气压力、催化剂用量)对反应的影响。实验结果表明,适宜的催化剂制备条件和反应条件为:Ni和Cu的来源分别为乙酸镍和硝酸铜、负载量分别为4%(w)和0.2%(w);反应温度210℃、氢气压力2 MPa、反应时间1 h、催化剂用量5%(w)(基于苯的质量)。在此条件下,苯的转化率可达57.74%,环己基苯的选择性可达71.38%。催化剂的金属活性位和酸性是苯加氢烷基化的关键因素。     

Deformation bands in fully pearlitic steel during wire drawing

The deformation of fully pearlitic steels during wire drawing has been investigated for both longitudinal section and transverse section by back-scattered electron imaging(BSEI),electron back-scattered diffraction(EBSD),and transmission electron microscope(TEM).The results show that a large number of deformation bands(DBs)composed of a mixture of kink-like bands and shear-like bands were observed both in the longitudinal section and the traverse section of the drawn wires.The formation of such bands involves two aspects:heterogeneous deformation in the scale of pearlite colonies and instability of ferrite-cementite interfaces due to stress concentration during wire drawing.The development of such bands in fully pearlitic steels dominates the formation of metallographic texture,reduces the pearlite interlamellar spacing and promotes the development of<110>fiber crystalline texture of ferrite matrix during wire drawing.     

对我校部分专业高数教学现状的分析与思考

通过抽样测试的方法,对学校部分专业高等数学的教学工作进行了调查研究,并在整理调研数据资料的基础上,对目前学校高等数学的教学状况进行了分析与评估,提出了一些思考性问题.     

螺旋钻孔机切削机构的理论分析

螺旋钻孔机是基建施工中常用的大型灌注桩施工机械。在进行成孔作业时，其钻具前端的切削刃的形态及其动态性能对整个切削过程有很大影响，这里通过理论比较和实验研究，对螺旋钻孔机切削机构的理论进行分析探讨，以寻求合理的设计理论依据。