Protein interaction networks: centrality,modularity, dynamics,and applications

In the post-genomic era, proteomics has achieved significant theoretical and practical advances with the development of high-throughput technologies. Especially the rapid accumulation of protein-protein interactions (PPIs) provides a foundation for constructing protein interaction networks (PINs), which can furnish a new perspective for understanding cellular organizations, processes, and functions at network level. In this paper, we present a comprehensive survey on three main characteristics of PINs: centrality, modularity, and dynamics. 1) Different centrality measures, which are used to calculate the importance of proteins, are summarized based on the structural characteristics of PINs or on the basis of its integrated biological information; 2) Different modularity definitions and various clustering algorithms for predicting protein complexes or identifying functional modules are introduced; 3) The dynamics of proteins, PPIs and sub-networks are discussed, respectively. Finally, the main applications of PINs in the complex diseases are reviewed, and the challenges and future research directions are also discussed.     

Design of the low power wake-up receiver for internet of things communication

A wake-up receiver with high energy efficiency and low power consumption is proposed for solving the power consuming problems of wireless nodes communication in the Internet of Things. The proposed wake-up receiver based on the wake-up mechanism can effectively schedule the network nodes communication, and use the simple envelope detection structure to achieve frequency down-conversion, which can flexibly manage energy and reduce power consumption. Based on UMC 65nm CMOS process technology, the wake-up receiver is designed and simulated. The results show that it can achieve S₁₁ of -21dBm and a sensitivity of -75dBm at a data rate of 1Mb/s, when operating at the central frequency of 780MHz and input signal adopting an on-off keying (OOK) modulation, and the power consumption is 82μW at 1.2V voltage supply.     

伸缩臂起重机液压控制的新趋势

从对现代化大型系列越野轮胎起重机的运动性能、起重性能和附加的要求出发,针对小型和大型两种起重机进行分析,给出主控制和回转机构控制的控制方案及发展趋势。     

一种双U形缺陷地结构低通滤波器的设计

基于双U形缺陷地结构设计了一种低通滤波器。首先利用三维电磁场仿真软件分析了双U形DGS结构的S参数频响特性,然后利用该DGS结构加工制作了DGS结构低通滤波器,实验室测得该滤波器3 dB截止频率为3．26 GHz,通带范围内波纹最大是0．4 dB。插入损耗大于20 dB的阻带宽度为5．2 GHz。     

Evolution of insoluble eutectic Si particles in anodic oxidation films during adipic-sulfuric acid anodizing processes of ZL114A aluminum alloys

The effects of insoluble eutectic Si particles on the growth of anodic oxide films on ZL114A aluminum alloy substrates were in-vestigated by optical microscopy (OM) and scanning electron microscopy (SE...     

强油非导向变压器热特性分析及优化设计

本文中作者借助流体软件对强油非导向变压器进行了热特性分析,并对变压器内部散热油路及冷却器进行了优化设计.     

Oxidation Performance of Fe-Al/WC Composite Coatings Produced by High Velocity Arc Sprayed at 650 ℃

Fe-Al intermetallics with remarkable high-temperatureintensity and excellent erosion,high-temperatureoxidation and sulfuration resistance are potential lowcost high-temperature structural material.ProducingFe-Al/WC composite coating by high velocity arcspraying(HVAS)on structural materials would notonly obviate the problems faced in fabrication of thesealloys into useful shapes,but also allow the effectiveuse of their outstanding high-temperature performance,which might thus promisingly mak…     

如何提高模具质量

介绍了提高模具质量的基本途径，分析了模具的正确使用与维护对其寿命的影响。     

钨钴硬质合金电化学蚀刻加工研究

对YG6硬质合金电化学蚀刻工艺进行了研究,提出了采用光致抗蚀剂作保护膜,在生成一定钝化膜的情况下进行电化学蚀刻的方法.在一定的蚀刻深度范围内,该工艺的可控性好、腐蚀区表面质量较好.