Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells

Tramadol hydrochloride is a centrally acting synthetic analgesic in widespread clinical use. Despite different degrees of opioid-like characteristics in preclinical tests, it is characterized by lack of full naloxone reversibility or naloxone-precipitated withdrawal in humans. To investigate this apparent discrepancy, the present study measured the affinity of tramadol (and its enantiomers) and an active O-desmethyl metabolite (M1) (and its enantiomers) to cloned human opioid receptors of the mu, delta and kappa type stably expressed in HN9.10 neuroblastoma cells. At mu sites, the Ki values for tramadol, its (+) and (-) enantiomers, M1, and its (+) and (-) enantiomers were 17000, 15700, 28800, 3190, 153 and 9680 nM, respectively, compared to 7.1 nM for morphine. These results are consistent with the suggestion of a non-opioid contribution to the clinical profile of tramadol.     

具有再生反馈雷达的角跟踪性能闭环测试

本文论述了用雷达跟踪目标最大角速度和角加速表征具有再生反馈雷达角跟踪性能的合理性,并论述了用单片机测试雷达跟踪目标最大角速度和最大角加速的方法。     

3D Motion Estimation and Motion Fusion by Affine Region Matching

In this paper,a new method is presented for 3D motion estimation by image region correspondences using stereo cameras.Under the weak perspectivity assumption.we first employ the moment tensor theory (Cyganski and Orr^[11]) to compute the monocular affine transformations relating images taken by the same camera at different time instants and the binocular affine transformations relating images taken by different cameras at the same time instant.We then show that 3D motion can be recovered from these 2D transformations.A space-time fusion strategy is proposed to aim at robust results.No knowledge of point correspondences if requred in the above processes and the computations involved are linear.To find corresponding image regions,new affine invariants,which show stronger invariance,are derived in term of tensor contraction theory.Experiments on real motion images are conducted to verify the proposed method.     

A method of calculating the compression deformation modulus of sandy and gravelly soils

A method based on use of Hardin's homogeneous model is proposed for calculation of the deformation modulus of noncohesive soils. Completely satisfactory correspondence between computed and experimental values of the deformation modulus of sands is demonstrated. Translated from Osnovaniya, Fundamenty i Mekhanika Gruntov, No. 4, pp. 2–5, July–August, 1994.     

碱性氰化物防渗碳光亮镀铜工艺的研究

本文介绍了一种高效率，高韧性，防渗碳底铜工艺，可以大辐度提高镀层的沉积速度，降低铜层孔隙率，提高产品合格率，具有显著的经济效益和社会效益。     

Application of artificial neural networks in voltage stabilityassessment

Voltage stability problems have been one of the major concerns for electric utilities as a result of system heavy loading. This paper reports on an investigation on the application of ANNs in voltage stability assessment. A multilayer feedforward artificial neural network (ANN) with error backpropagation learning is proposed for calculation of voltage stability margins (VSM). Based on the energy method, a direct mapping relation between power system loading conditions and the VSMs is set up via the ANN. A systematic method for selecting the ANN's input variables was developed using sensitivity analysis. The effects of ANN's training pattern sensitivity problems were also studied by dividing system operating conditions into several loading levels based on sensitivity analysis. Extensive testing of the proposed ANN-based approach indicate its viability for power system voltage stability assessment. Simulation results on five test systems are reported in the paper     

中温低氰液体碳氮共渗及其应用效果

通过金相、硬度、耐磨性等测试分析表明，在“６０３”液体渗碳基础上研制出的新型中温低氰液体碳氮共渗剂对薄片件进行薄层碳氮共渗．能完全满足技术要求，并且取得了良好经济和社会效益．     

七九四矿原地破碎堆浸采铀试验研究简况

本文简要介绍了七九四矿原地破碎堆浸采铀的试验情况，分析了可行性和应研究解决的若干问题。     

An improved method for magnetic identification and localization of cracks in conductors

A SQUID magnetometer can be used to measure the magnetic field produced by flaws in a two-dimensional, conducting plate carrying a current. Identification of the flaw-induced magnetic field is difficult because of the large magnetic field associated with the edges of the plate and the current in the leads that connect the plate to the power supply. We have developed a technique by which the wire and edge fields can be cancelled prior to mapping the magnetic field. In this technique, a similar unflawed conducting sheet is placed adjacent to the flawed plate, with a connection between the sheet and the plate at one edge, and with the opposite edges of the sheet and of the plate connected to the two conductors of a coaxial cable. Thus, an applied current will flow along one conductor of the cable, across the cancelling sheet, cross into the flawed plate, return along the plate, and then return to the power supply along the other conductor of the coaxial cable. As a result of this geometry, there is no magnetic field from the lead-in wires because they are coaxial, and the magnetic field due to the edges of the plate is cancelled by the opposing magnetic field of the edges in the adjacent sheet. The extent of cancellation is determined primarily by the separation between the plate and the cancelling sheet, by the thickness of the plate, and by macroscopic inhomogeneities in their electrical conductivities.     

Characterization of expression of phosphofructokinase isoforms in isolated rat pancreatic islets and purified beta cells and cloning and expression of the rat phosphofructokinase-A isoform

We prepared polymers having a phospholipid polar group, poly [omega-methacryloyloxyalkyl phosphorylcholine (MAPC)-co-n-butyl methacrylate(BMA)], as new biomedical materials and evaluated their blood compatibility with attention to protein adsorption and platelet adhesion. The total amount of proteins adsorbed on the polymer surface from human plasma was determined, and the distribution of adsorbed proteins on the plasma-contacting surface was analyzed. The amount of proteins adsorbed on every poly (MAPC-co-BMA) was small compared with that observed on polymers without the phospholipid polar group. However, there was no significant difference in the amount of adsorbed proteins on the poly(MAPC-co-BMA) even when the methylene chain length between the phospholipid polar group and the backbone in the MAPC moiety was altered. Platelet adhesion on the polymer surface from a platelet suspension in a buffered solution was evaluated with and without plasma treatment on the surface. When a rabbit platelet suspension was brought into contact with the poly(BMA) surface after treatment with plasma, many platelets adhered and aggregated. However, a reduced amount of platelet adhered on the poly(BMA) was found in the case of direct contact with the platelet suspension. On the other hand, the poly(MAPC-co-BMA)s could inhibit platelet adhesion under both conditions. Based on these results, it can be concluded that the proteins adsorbed on the surface play an important role in determining the platelet adhesion and suppression of the protein adsorption on the surface, which is one of the most significant ways of inhibiting platelet adhesion.