Microneedles are small needle‐like structures that are almost invisible to the naked eye. They have an immense potential to serve as a valuable tool in many medical applications, such as painless vaccination. Microneedles work by breaking through the stratum corneum, the outermost barrier layer of the skin, and providing a direct path for drug delivery into the skin. A lot of research has been presented over the past two decades on the applications of microneedles, yet the fundamental mechanism of how they interact, pressure, and penetrate the skin in its native state is worth examining further. As such, a major difficulty with understanding the mechanism of microneedle–skin interaction is the lack of an artificial mechanical human skin model to use as a standardized substrate. In this research news, the development of an artificial mechanical skin model based on a thorough mechanical study of fresh human and porcine skin samples is presented. The artificial mechanical skin model can be used to study the mechanical interactions between microneedles and skin, but not diffusion of molecules across skin. This model can assist in improving the performance of microneedles by enhancing the reproducibility of microneedle depth insertions for optimal drug delivery and biosensing.
Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP) and red light at 660 nm. The effect of MB-NP-based aPDT was also evaluated in a clinical pilot study with 10 adult human subjects with chronic periodontitis. Dental plaque samples from human subjects were exposed to aPDT—in planktonic and biofilm phases—with MB or MB-NP (25 µg/mL) at 20 J/cm2in vitro. Patients were treated either with ultrasonic scaling and scaling and root planing (US + SRP) or ultrasonic scaling + SRP + aPDT with MB-NP (25 µg/mL and 20 J/cm2) in a split-mouth design. In biofilms, MB-NP eliminated approximately 25% more bacteria than free MB. The clinical study demonstrated the safety of aPDT. Both groups showed similar improvements of clinical parameters one month following treatments. However, at three months ultrasonic SRP + aPDT showed a greater effect (28.82%) on gingival bleeding index (GBI) compared to ultrasonic SRP. The utilization of PLGA nanoparticles encapsulated with MB may be a promising adjunct in antimicrobial periodontal treatment. 相似文献
Metallurgical and Materials Transactions B - Production of ferronickel alloy by thermal treatment of nickeliferous pyrrhotite (Pyrr) tailings was studied by both thermodynamic assessment and... 相似文献
In this work, using electrochemical techniques the authors investigated the protective properties of a polypyrrole/polyaniline bilayer as a conductive polymer. A polypyrrole/polyaniline bilayer was deposited on carbon steel substrate by potentiostatic method. The electric capacitance and resistance of the films were monitored with the immersion time in a corrosive solution to investigate the water permeability of the films. Polypyrrole/polyaniline bilayer has a relatively low permeability and good catalytic behavior in passivation of carbon steel in longer periods. The results show that the bilayer has a better anticorrosive behavior compared to homopolymers (polypyrrole and polyaniline). 相似文献
Various zinc oxide nanostructures were synthesized using thermal decomposition of zinc acetate dihydrate in a single process. The characterization of samples using powder X-ray diffraction, scanning electron microscope and FT-IR measurements revealed that the pure phase of different morphologies such as nanoparticles, nanowires and nanodisks had been synthesized successfully. Surprisingly some synthesized ZnO nanostructures were dark gray. The results showed that the reason may have been related to the oxygen deficiency and strong asymmetric stretching mode of wurtzite ZnO nanostructure. Using such samples, the photodegradation of Methylene blue was performed by UV–vis absorption measurement and the effect of morphology on the photocatalytic properties of different ZnO nanostructures was examined. The results showed that the nanodisks had the best photocatalytic performance among the other morphologies. The reason was attributed to the presence of specific crystal planes such as (0001) facets in nanodisks which can improve their photocatalytic performance. 相似文献
Friction stir processing of AZ31 Mg alloy was investigated by numerical modeling and experiments. A CFD based, fully coupled, 3D, thermo-mechanical model was built to better understand the effect of process parameters on temperature, material flow and strain rate. In order to account for material softening phenomena at elevated temperatures and extremely high strain rates that occur during the FSP process, experimentally measured peak temperatures were utilized to introduce a correction function in the flow stress constitutive relation. The numerical results showed that rotational speed as compared to translational speed had a more dominant effect on temperature field and strain rate. In addition, the asymmetric material flow around the tool axis caused higher peak temperature and strain rate on the advancing side (AS), while the material in the path of tool pin was swept around the retreating side (RS). FSP experiments confirmed peak temperatures measured at sheet surface near shoulder perimeter on AS were always higher than corresponding RS peak temperatures, under the selected range of process parameters. In addition to thermo-mechanical aspects, the metallurgical characteristics of FSP i.e. mainly the grain size evolution was studied by optical and electron microscopy. Experiments revealed that the coarse bimodal microstructure of as-received AZ31 Mg was subdivided into a defect-free, fine grain microstructure at the rotational speed of 1000 rpm, while a defect-free but a relatively coarse and bimodal microstructure evolved in the material at rotational speeds higher than 1000 rpm. Furthermore, in the selected range of process parameters the increases in translational speed resulted in finer grain sizes without the formation of voids or defects. 相似文献
The purification of metallurgical grade silicon (MG-Si) using a combination of solvent refining and physical separation is
studied. MG-Si was alloyed with iron and solidified under different cooling rates in order to grow pure Si dendrites from
the alloy. The Si dendrites were then separated using a gravity-based method. The separation method relies on the significantly
different densities of Si and FeSi2, and it uses a heavy liquid with specific gravity between the two phases to float the light Si particles to the surface of
the liquid, while the heavy iron silicide sinks. The effects of the particle size and cooling rate on the yield and separation
efficiency of the Si phase were investigated by quantifying the fraction of Si in the sinks and floats. The results demonstrate
that the crushing size of the particles prior to separation should be approximately the same as the width of the dendrites
in order to maximize the separation efficiency while simultaneously lowering the grinding cost. 相似文献