Log-linear allometry of fetal craniofacial growth in Down's syndrome

Trisomy 21 develops as a result of nondisjunction of two homologous chromosomes during either the first or second meiotic division. One of the more important consequences of these genetic alterations is the predictable, although variable disturbance in the architecture of the craniofacial region [1]. Postnatal craniofacial morphology has been extensively studied in Down's syndrome (DS). However, little information is available on human prenatal development of the head and face in such patients. The time at which changes in craniofacial phenotype first emerge in Down's syndrome fetuses and at which physical growth begins to diverge from normal is unknown. To explore these questions, we compared prenatal craniofacial growth in 50 Down's syndrome fetuses with that of 555 fetuses judged to be "typical for body weight and age" using the method of log-linear allometry [2].     

Selective detection of molecular ions in dc discharges by dual-beam Fourier transform spectroscopy

A new method to detect molecular ions selectively in gas discharges by Fourier transform emission spectroscopy is proposed. This method is by dual-beam optical subtraction. The difference spectrum between blue and red Doppler-shifted components is obtained directly thus eliminating the large background that is due to neutral precursors.     

Sleep-induced breathing instability. University of Wisconsin-Madison Sleep and respiration Research Group

We present a view of the neuromechanical regulation of breathing and causes of breathing instability during sleep. First, we would expect transient increases in upper airway resistance to be a major cause of transient hypopnea. This occurs in sleep because a hypotonic upper airway is more susceptible to narrowing and because the immediate excitatory increase in respiratory motor output in response to increased loads is absent in non-REM sleep. Secondly, sleep predisposes to an increased occurrence of ventilatory "overshoots", in part because abruptly changing sleep states cause transient changes in upper airway resistance and in the gain of the respiratory controller. Following these ventilatory overshoots, breathing stability will be maintained if excitatory short-term potentiation is the prevailing influence. On the other hand, apnea and hypopnea will occur if inhibitory mechanisms dominate following the ventilatory overshoot. These inhibitory mechanisms include: a) hypocapnia-if transient, will inhibit carotid chemoreceptors and cause hypopnea, but if prolonged will inhibit medullary chemoreceptors and cause apnea; b) a persistent inhibitory effect from lung stretch; c) baroreceptor stimulation, from a transient rise in systemic blood pressure immediately following termination of apnea or hypopnea may partially suppress the accompanying hyperpnea; d) depression of central respiratory motor output via prolonged brain hypoxia. Once apneas are initiated, reinitiation of inspiration is delayed even though excitatory stimuli have risen well above their apneic thresholds, and these prolonged apneas are commonly accompanied by tonic EMG activation of expiratory muscles of the chest wall and upper airway.     

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DuD Report

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Smooth velocity approximation for constrained systems in real-time simulation

The rapidly increasing complexity of multi-body system models in applications like vehicle dynamics, robotics and bio-mechanics requires qualitative new solution methods to slash computing times for the dynamical simulation.     

The Complexity of Hybrid Logics over Equivalence Relations

This paper examines and classifies the computational complexity of model checking and satisfiability for hybrid logics over frames with equivalence relations. The considered languages contain all possible combinations of the downarrow binder, the existential binder, the satisfaction operator, and the global modality, ranging from the minimal hybrid language to very expressive languages. For model checking, we separate polynomial-time solvable from PSPACE-complete cases, and for satisfiability, we exhibit cases complete for NP, PSpace, NExpTime, and even N2ExpTime. Our analysis includes the versions of all these languages without atomic propositions, and also complete frames.     

Evaluation of the effect of a paver’s trolley on productivity, task demands, workload and local discomfort

The objective of this study was to determine the differences in the number of paving stones laid (productivity), task demands, energetic workload, body region discomfort and preference when laying paving stones with or without use of a paver’s trolley (n = 8) in a within-subject controlled study of pavers. The number of paving stones laid and the task demands were measured by means of systematic observations at the workplace. The energetic workload was determined using the percentage of heart rate reserve (%HRR). Body region discomfort was measured using visual analog scales, and the workers’ preference was ascertained via interview. The use of a paver’s trolley had no effect on productivity, %HRR or body region discomfort compared to working without a paver’s trolley. The duration of knee-straining activities did not differ between working with (141 min) and without (146 min) the paver’s trolley. However, six of the eight pavers indicated that, given suitable circumstances, they wanted to use the paver’s trolley.

Relevance to industry

To reduce the chance of work-related low back and knee complaints among pavers, the duration, frequency and intensity of lower back and knee-straining activities should be limited by means of technical measures such as mechanical paving. The paver’s trolley does not appear to reduce knee-straining activities and therefore does not appear useful in reducing the risk of knee complaints and disorders.