Amphiphilic Poly(Amino Acid) Nanoparticles Induce Size‐Dependent Dendritic Cell Maturation

Size‐regulated amphiphilic poly(amino acid) nanoparticles (NPs) composed of poly(γ‐glutamic acid) (γ‐PGA) and the hydrophobic amino acid derivative, L ‐phenylalanine ethyl ester (Phe) are prepared to evaluate the effects of particle size on dendritic cell (DC) uptake of NPs and their immune stimulatory activities as delivery carriers and adjuvants. The size of the Phe‐conjugated γ‐PGA NPs (γ‐PGA–Phe NPs) is easily controlled by regulating the aggregated γ‐PGA–Phe numbers. Each of the differently sized γ‐PGA–Phe NPs could efficiently encapsulate ovalbumin (OVA), and the amount of encapsulated OVA per milligram of NPs is almost the same despite the differences in size. The DC uptake of small NPs is lower than for the larger NPs, but the effect of DC activation by NPs is high in the small sizes. The DC activation is significantly affected by the size of the NPs, which suggests that not only the uptake process of the NPs, but also the surface interactions between the NPs and DCs, is important for the induction of DC maturation. The precisely size‐controllable γ‐PGA–Phe NPs have significant potential as an antigen carrier and vaccine adjuvant. These results should provide guidelines for adjuvant design in the development of an effective vaccine.     

First-Principles Investigation of the Atomic and Electronic Structures of α-Al2O3(0001)/Ni(111) Interfaces

Atomic and electronic structures of α-Al₂O₃(0001)/Ni(111) interfaces have been investigated using the first-principles pseudopotential method. Models with different rigid-body translations parallel to the interface for both the O-terminated and Al-terminated interfaces are examined in order to clarify the overall features. Results indicate that the interface stoichiometry as well as the interface configuration has significant effects on the adhesive and electronic properties. The bonding nature of the O-terminated interfaces is explained by strong ionic and Ni-3d/O-2p orbital hybridization interactions, and that of the Al-terminated interfaces is explained mainly by image-charge like electrostatic and Ni–Al hybridization interactions, although there is some Ni–O hybridization for the O-site model. Orbital hybridization and adhesive energies are larger than those in the corresponding Al₂O₃/Cu interfaces, because Ni has higher activity for making bonds with ceramics than Cu.     

A feasibility study for the removal of copper from solid ferrous scrap

A new approach for the removal of copper from solid ferrous scrap is described. With this proposal, solid ferrous scrap intermingled with copper is brought into contact with molten aluminium, which preferentially dissolves copper. After a duration of 5 to 10 minutes at a temperature of 1018 ± 5 K, steel scrap is removed from the bath, resulting in being free of copper contamination. The present method offers the advantage of far lower costs than any other processes ever suggested for copper removal.     

Analysis of electromagnetic force in wire-EDM

This paper clarifies the mechanism of how electromagnetic force applied to the wire electrode in wire electrical discharge machining (wire-EDM) is generated. This electromagnetic force is caused not only by DC component but also by AC components of the discharge current supplied to the wire. We therefore developed and used a two-dimensional finite element method (FEM) program to analyze the electromagnetic field taking into account electromagnetic induction. Assuming that trapezoidal pulse current is supplied to the wire, distributions of the current density and magnetic flux density were analyzed and changes in the electromagnetic force applied to the wire were calculated. Wire movement when the electromagnetic force alone was applied to the wire was also calculated. The calculated wire movement agreed with the measured wire movement when pulse current actually used in WEDM was supplied to the wire, clarifying the mechanism of electromagnetic force generation.     

Scandium-Doped Anatase (TiO2) Nanoparticles Directly Formed by Hydrothermal Crystallization

Anatase-type TiO₂ solid solutions doped with 0–10 mol% scandium were formed by hydrothermal crystallization under weak basic conditions above 180°C for 5 h from amorphous co-precipitates that were obtained from the aqueous precursor solutions of TiOSO₄ and Sc(NO₃)₃ using aqueous ammonia. The anatase particles were spindle-like and consisted of nanosized-crystallites (23–25 nm). The lattice parameter c ₀ of anatase and the length and width of the spindle-like anatase gradually increased when the scandium content was increased. The diffuse reflectance spectra of the as-prepared TiO₂ doped with scandium showed that the onset of absorption slightly shifted to longer wavelengths with increasing scandium content. The band gap of anatase was slightly increased by making solid solutions with scandium oxide.     

Group feature extraction based on matrix factorization from long-range office-logging data

To increase the productivity of knowledge workers, it is necessary to manage their organization so that they are motivated to collaborate with each other for their synergy. However, it is difficult for managers to grasp the explicit interactions of workers in the organization all the time. Owing to advanced communications technology, and the reduced size and improved capabilities of computers, we are able to record group behaviors as logging data in the office. The aim of this study is to extract features of group behavior from long-range office-logging data. We apply principal component analysis to the data matrix whose element is the mean travel velocity calculated from an individual’s trajectory per day. The results demonstrate the feasibility of our approach, since nontrivial informative group features can be extracted.     

Investigation on the effectiveness of various methods of information dissemination aiming at a change of occupant behaviour related to thermal comfort and exergy consumption

These days the number of projects trying to urge a change in the occupant's behaviour towards a sustainable one is increasing. However, still less is known about the effect of such measures. This paper describes the findings of two investigations, a field measurement and an Internet-based survey, both including the dissemination of information about strategies for a high level of comfort without much energy usage. The focus was on the ability to quantify the effect of such measures on the heating and cooling behaviour. As a result, those who participated in a workshop were more likely to change their behaviour than those who received an information brochure only; whether this was due to the method employed or the type of participants could not be ascertained. However, the workshop participants reduced their cooling device usage by up to 16%. The concept of exergy was used to show how this reduction affects the exergy consumption of the cooling device, because it enables us to consider the qualitative aspect of energy as a quantity to be calculated. This showed that the exergy consumed by the workshop group was reduced by up to 20% comparing their behaviour before and after the information dissemination.     

Size-controlled oxidation-resistant copper fine particles covered by biopolymer nanoskin

Size-controlled oxidation-resistant copper fine particles were prepared from insoluble CuO micron-sized particles. The particle sizes were quite uniform and could be varied only by the concentration of the complex reagent from 45 to 175 nm. No template material was needed for size control. Gelatin was selected as the protective polymer. Addition of protease after formation of copper fine particles decomposed preferentially loop and tail parts of gelatin. The remaining nanoskin gelatin layer, covered on the particle surface, prevents oxidation of copper.     

Activities of FexO in CaO + CaF2 + SiO2 + FexO quaternary slags by disposable electrochemical oxygen probes

The activities of Fe_xO in CaO + CaF₂ + SiO₂ + Fe_xO quaternary slags were measured by means of solid-oxide galvanic cell. The Fe_xO activities in the slags are influenced by CaF₂ as well as SiO₂. At constant Fe_xO mole fractions, e.g., , at low SiO₂ mole fractions i.e., , the substitution of CaF₂ for CaO has an effect of raising the Fe_xO activity. At higher SiO₂ mole fractions, e.g., , however, such an effect becomes insignificant.     

Highly disordered ionic distribution in α-dicalcium silicate for structure relaxation

Dicalcium silicate, which is found in steelmaking slag for dephosphorization, exists as the hexagonal α phase at high temperatures. The α-dicalcium silicate forms a solid solution with tricalcium phosphate in the entire composition range, although the reason for high solubility of phosphorus remains unclear in view of the crystal structure. It has previously been reported that the crystal structure of α-dicalcium silicate consists of a symmetric arrangement of Ca²⁺ ions and SiO₄⁴⁻ tetrahedra, although other polymorphs exhibit asymmetric arrangements. However, because the occupation probability of each atomic site in the α polymorph is not limited to unity, it has not been qualified how these ions are exactly arranged. In this study, the ionic distribution in the α polymorph of dicalcium silicate was evaluated by first-principles calculation based on density functional theory (DFT), as well as by molecular dynamics (MD) simulation with a polarizable ion model optimized by DFT calculation. The results indicated that the completely symmetric ionic arrangement, as reported for the α phase, is the most unstable. Electronic-state calculation and MD simulation indicated that a highly disordered ionic arrangement spontaneously forms in the α-phase crystal for structure relaxation when held at high temperatures, or when phosphorus is incorporated.