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101.
Influence of vineyard altitude on Glera grape ripening (Vitis vinifera L.): effects on aroma evolution and wine sensory profile 下载免费PDF全文
102.
Massimiliano Gobbi 《Optimization and Engineering》2013,14(2):345-360
In the paper, a multi objective genetic algorithm based on the concept of k-optimality and k-ε-optimality (KEMOGA) is introduced and applied. Pareto optimality alone is not always adequate for selecting a final solution because the Pareto optimal set can be very large. The k-optimality approach and the more general k-ε-optimality method, can be used to rank the Pareto-optimal solutions. The two methods have been included into a genetic algorithm selection procedure. The k-optimality method searches for points which remain Pareto-optimal when all of the subsets of n-k objectives (n is the number of objective functions) are optimised. The k-ε approach considers not only if an objective is worse than the others but also the entity of this variation through the introduction of a vector of indifference thresholds. The KEMOGA has been applied for the solution of two engineering problems. The selection of the stiffness and damping of a passively suspended vehicle in order to get the best compromise between discomfort, road holding and working space and a complex problem related to the optimisation of the tyre/suspension system of a sport car. The final design solution, found by means of the KEMOGA seems consistent with the solution selected by skilled suspensions specialists. The proposed approach has been tested and validated on a complex optimization problem. The solved problem deals with the optimization of the tyre/suspension system of a sport car. The proposed approach (KEMOGA) has shown to be very effective in terms of computational efficiency and accuracy. 相似文献
103.
Galdiero S Vitiello M D'Isanto M Falanga A Cantisani M Browne H Pedone C Galdiero M 《Chembiochem : a European journal of chemical biology》2008,9(5):758-767
The molecular mechanism of entry of herpes viruses requires a multicomponent fusion system. Virus entry and cell-cell fusion of Herpes simplex virus (HSV) requires four glycoproteins: gD, gB and gH/gL. The role of gB remained elusive until recently, when the crystal structure of HSV-1 gB became available. Glycoprotein B homologues represent the most highly conserved group of herpes virus glycoproteins; however, despite the high degree of sequence and structural conservation, differences in post-translational processing are observed for different members of this virus family. Whereas gB of HSV is not proteolytically processed after oligomerization, most other gB homologues are cleaved by a cellular protease into subunits that remain linked through disulfide bonds. Proteolytic cleavage is common for activation of many other viral fusion proteins, so it remains difficult to envisage a common role for different herpes virus gB structures in the fusion mechanism. We selected bovine herpes virus type 1 (BoHV-1) and herpes simplex virus type 1 (HSV-1) as representative viruses expressing cleaved and uncleaved gBs, and have screened their amino acid sequences for regions of highly interfacial hydrophobicity. Synthetic peptides corresponding to such regions were tested for their ability to induce the fusion of large unilamellar vesicles and to inhibit herpes virus infection. These results underline that several regions of the gB protein are involved in the mechanism of membrane interaction. 相似文献
104.
Giuseppe BattistoniFrancesco Broggi Markus BruggerMauro Campanella Massimo CarboniAnton Empl Alberto FassòEttore Gadioli Francesco CeruttiAlfredo Ferrari Anna FerrariMatthias Lantz Andrea MairaniM. Margiotta Cristina MoroneSilvia Muraro Katia ParodiVincenzo Patera Mauricio PelliccioniLarry Pinsky Johannes RanftStefan Roesler Sofia RolletPaola R. Sala Mario SantanaLucia Sarchiapone Massimiliano SioliGeorge Smirnov Florian SommererChristian Theis Stefania TrovatiR. Villari Heinz VinckeHelmut Vincke Vasilis Vlachoudis Joachim VollaireNeil Zapp 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》2011,269(24):2850-2856
105.
Stefania Tronci Salvatore Coppola Fabio Bacchelli Massimiliano Grosso 《Polymer Engineering and Science》2013,53(6):1241-1252
Fiber spinning experiments are conducted with a capillary rheometer and a Rheotens tester on linear styrene‐isoprene‐styrene copolymer samples by varying extrusion temperature and drawdown velocity in a wide range of values, also covering the occurrence of instability phenomena. Tensile stress is measured during the experiences, and the experimental time series are then analyzed by means of a new methodology. The proposed approach is based on Neural Network modeling of the time series, coupled with Principal Component Analysis postprocessing of the results. The methodology is able to identify and quantify the effects of process condition on the dynamical behavior of the system. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers 相似文献
106.
Margherita Durso Cristian Bettini Alberto Zanelli Massimo Gazzano M. Grazia Lobello Filippo De Angelis Viviana Biondo Denis Gentili Raffaella Capelli Massimiliano Cavallini Stefano Toffanin Michele Muccini Manuela Melucci 《Organic Electronics》2013,14(11):3089-3097
The synthesis of two new thieno(bis)imide (TBI, N) end functionalized oligothiophene semiconductors is reported. In particular, trimer (NT3N) and pentamer (NT5N) have been synthesized and characterized. Two different synthetic approaches for their preparation were tested and compared namely conventional Stille cross coupling and direct arylation reaction via C–H activation. Theoretical calculations, optical and electrochemical characterization allowed us to assess the role of the π-conjugation extent, i.e., of the oligomer size on the optoelectronic properties of these materials. In both TBI ended compounds, due to the strong localization of the LUMO orbital on the TBI unit, the LUMO energy is almost insensitive to the oligomer size, this being crucial for the fine-tailoring of the energy and the distribution of the frontier orbitals. Surprisingly, despite its short size and contrarily to comparable TBI-free analogues, NT3N shows electron charge transport with mobility up to μN = 10−4 cm2 V−1 s−1, while increasing the oligomer size to NT5N promotes ambipolar behavior and electroluminescence properties with mobility up to μN = 0.14 cm2 V−1 s−1 and to μP = 10−5 cm2 V−1 s−1. 相似文献
107.
Luigi Schibuola Massimiliano Scarpa Chiara Tambani 《能源与动力工程:英文版》2014,(6):1012-1020
The reliable assessment of the annual energy demand has become necessary in view of building energy performance certification. Accurate models must be used to simulate the behaviour of HVAC (heating, ventilation and air conditioning) components in real operation, usually characterized by a wide variation of building loads. In this context, this paper deals with the development and validation of an algorithm aimed at the assessment of part load performance of various kinds of controls for vapour compresion based heat pumps and chillers, in particular referring to on-off, inverter-driven and multi-stage vapour compression. The reliability of this algorithm in the calculation of seasonal performances is checked against monitoring of heat pumps and chillers operating under real conditions. 相似文献
108.
Lucio Boschetti Matteo Ottavian Pierantonio Facco Massimiliano Barolo Lorenzo Serva Stefania Balzan Enrico Novelli 《Meat science》2013
The use of near-infrared spectroscopy (NIRS) is proposed in this study for the characterization of the quality parameters of a smoked and dry-cured meat product known as Bauernspeck (originally from Northern Italy), as well as of some technological traits of the pork carcass used for its manufacturing. In particular, NIRS is shown to successfully estimate several key quality parameters (including water activity, moisture, dry matter, ash and protein content), suggesting its suitability for real time application in replacement of expensive and time consuming chemical analysis. Furthermore, a correlative approach based on canonical correlation analysis was used to investigate the spectral regions that are mostly correlated to the characteristics of interest. The identification of these regions, which can be linked to the absorbance of the main functional chemical groups, is intended to provide a better understanding of the chemical structure of the substrate under investigation. 相似文献
109.
Stefania Galdiero Annarita Falanga Marco Cantisani Mariateresa Vitiello Giancarlo Morelli Massimiliano Galdiero 《International journal of molecular sciences》2013,14(9):18758-18789
The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated cellular processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. Moreover, a major goal of modern biotechnology is obtaining new potent pharmaceutical agents whose biological action is dependent on the binding of peptides to lipid-bilayers. Several issues need to be addressed such as secondary structure, orientation, oligomerization and localization inside the membrane. At the same time, the structural effects which the peptides cause on the lipid bilayer are important for the interactions and need to be elucidated. The structural characterization of membrane active peptides in membranes is a harsh experimental challenge. It is in fact accepted that no single experimental technique can give a complete structural picture of the interaction, but rather a combination of different techniques is necessary. 相似文献
110.
Ehud Greenspan Ser Gi Hong Ki Bog Lee Lanfranco Monti Tsuyoshi Okawa Arnaud Susplugas Massimiliano Fratoni Lance Kim Sara Mattafirri Robert Petroski 《Progress in Nuclear Energy》2008,50(2-6):129-139
A number of approaches were explored for improving characteristics of the encapsulated nuclear heat source (ENHS) reactor and its fuel cycle, including: increasing the ENHS module power, power density and the specific power, making the core design insensitive to the actinides composition variation with number of fuel recycling and reducing the positive void coefficient of reactivity. Design innovations examined for power increase include intermediate heat exchanger (IHX) design optimization, riser diameter optimization, introducing a flow partition inside the riser, increasing the cooling time of the LWR discharged TRU, increasing the minor actinides' concentration in the loaded fuel and split-enrichment for power flattening. Another design innovation described utilizes a unique synergism between the use of MA and the design of reduced power ENHS cores.
Also described is a radically different ENHS reactor concept that has a solid core from which heat pipes transport the fission power to a coolant circulating around the reflector. Promising features of this design concept include enhanced decay heat removal capability; no positive void reactivity coefficient; no direct contact between the fuel clad and the coolant; a core that is more robust for transportation; higher coolant temperature potentially offering higher energy conversion efficiency and hydrogen production capability. 相似文献