Effective section method: A general direct method for the design of steel cold-formed members under local–global buckling interaction

Thin-walled steel cold-formed members usually display local–global buckling interaction which strongly affects the structural strength of columns and beams. The local bucking of slender folded sections develops in analogy with single plate buckling, including the interaction between the plate elements of the cross-section and can be identified with appropriate first-order stability analysis and the consequent results of the critical buckling loads and the associated modes. The effective section method, ESM, as an extension of the original effective area method, EAM, was conceived for the design of cold-formed members on the basis of the actual local buckling results of the section, together with calibrated formulations for column and beam resistance. The strength equations were taken from the direct strength method, DSM, as it is presented in the North American AISI standard. In addition, as a consequence of its proposed formulation the effective section method is able to be applied side-by-side with the traditional effective width method, EWM, allowing its inclusion in the main part of the codes and specifications for the design of cold-formed members and improving its dissemination. The ESM was proposed in combination with equations and tables that enables designers to directly access the critical local buckling compressive force and bending moment of usual sections, resulting in a contribution that improves the attractiveness of the method.     

Technological windows for MIAB welding of tubes featuring original longitudinal magnetization system with peripheral solenoids

This paper presents the performances of an original longitudinal magnetization system, designed to assure the magnetic flux concentration on the tube wall. This magnetization system is made of several small peripheral solenoids disposed around each tube, parallel to the tube axis, and was used to investigate the interaction between the arc and the magnetic field in case of MIAB (Magnetically Impelled Arc Butt) welding of low carbon steel thin-walled tubes. The main research objective was the development of process parametrical windows for assuring qualitative joint achievement. Macro- and micro-structural analysis accompanies the hardness tests made on corresponding welded samples, demonstrating the operational process maps in producing sound MIAB joints. The paper also discusses the process main stages based on corresponding images resulting from process monitoring, from arc initiation to the emergence of molten metal when upsetting starts and the weld is formed.     

Effect of temperature on the pre-creep mechanical properties of silicon nitride

The elasto-plastic properties and contact damage evolution of a commercial polycrystalline silicon nitride are evaluated as a function of temperature up to 1000 °C, using a recently developed method combining Hertzian indentation and FEM simulation. The results of the study are compared to existing data for other ceramic materials such as alumina and zirconia. Silicon nitride is found to exhibit an excellent combination of elasto-plastic properties in the pre-creep temperature range and good contact damage resistance. These qualities make this material ideal for high temperature applications in general, and in particular to be used in spherical indenters for the evaluation of mechanical properties of other materials at elevated temperature using the procedure applied in this work.     

Hippocampal and caudate metabolic activity associated with different navigational strategies.

Hippocampal and striatal systems are widely related to spatial tasks. Depending on the strategies used, different memory systems can be activated. In this study, the authors used the cytochrome c-oxidase technique as a functional marker of the hippocampal and dorsal striatum activity related to training in several water maze tasks. Current results show a differential participation of the hippocampal and striatal systems in navigation. When spatial information is relevant, participation of the hippocampal system is more important, and when the task is similar to a response learning one, the striatal system is more active. According to computational models, CA3 seems to be more active when the associative demand is higher, whereas CA1 and dentate gyrus activity are higher when spatial information processing is required. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Labs of the World, Unite!!!

eScience is rapidly changing the way we do research. As a result, many research labs now need non-trivial computational power. Grid and voluntary computing are well-established solutions for this need. However, not all labs can effectively benefit from these technologies. In particular, small and medium research labs (which are the majority of the labs in the world) have a hard time using these technologies as they demand high visibility projects and/or high-qualified computer personnel. This paper describes OurGrid, a system designed to fill this gap. OurGrid is an open, free-to-join, cooperative Grid in which labs donate their idle computational resources in exchange for accessing other labs’ idle resources when needed. It relies on an incentive mechanism that makes it in the best interest of participants to collaborate with the system, employs a novel application scheduling technique that demands very little information, and uses virtual machines to isolate applications and thus provide security. The vision is that OurGrid enables labs to combine their resources in a massive worldwide computing platform. OurGrid is in production since December 2004. Any lab can join it by downloading its software from .     

Materials Behavior in Laser Welding of Hardmetals to Steel

Tool manufacturing industry faces the problem of permanently joining hardmetals to steel holders with high shear strength. The mostly used welding process still is brazing. However, brazed joints have poor lifetimes, mostly when high temperatures are achieved and often break in operation. In a previous study about the ability of CO₂ and Nd:YAG lasers to weld hardmetals to steels, it was found that Nd:YAG lasers, working in continuous wave mode, could be used especially for welding hardmetals with Co content around 12%. This article discusses the materials behavior under laser radiation and analyzes the microstructural features observed.     

Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole

OBJECTIVE: To study the effect of adjuvant chemotherapy after curative hepatic resection in patients with hepatocellular carcinoma. DESIGN: A randomized controlled trial. SETTING: A tertiary referral center. PATIENTS: During a 54-month period, 142 patients with hepatocellular carcinoma underwent hepatic resection at 1 institution. Sixty-six patients who survived the operation and had no demonstrable evidence of residual disease on ultrasonographic examination and hepatic angiographic testing at 1 month after surgery agreed to participate in the study. The median follow-up time was 28.3 months. INTERVENTION: Thirty patients received a combination of intravenous epirubicin hydrochloride (8 doses of 40 mg/m2 each at 6-week intervals) and transarterial chemotherapy using an emulsion of iodized oil and cisplatin (3 courses with a maximum dose of 20 mL each at 2-month intervals). Thirty-six patients had no adjuvant treatment. MAIN OUTCOME MEASURES: Recurrence rate and disease-free survival. RESULTS: A total of 138 courses of intravenous epirubicin was given to the 30 patients. Sixty-one courses of transarterial chemotherapy were given to only 29 of the 30 patients assigned to the treatment group, because the hepatic artery in 1 patient was thrombosed. Six patients (20%) had chemotherapy-related complications with no mortality. Twenty-three of 30 patients in the treatment group and 17 of 36 patients in the control group had recurrences (P=.01). Patients who received adjuvant chemotherapy had a higher incidence of extrahepatic metastases (11 patients vs 5 patients; P=.03). The respective disease-free survival rates at 1, 2, and 3 years were 50%,36%, and 18% for the treatment group and 69%, 53%, and 48% for the control group (P=.04). CONCLUSION: In a group of patients who underwent curative resection of hepatocellular carcinoma, postoperative adjuvant chemotherapy using the present regimen was associated with more frequent extrahepatic recurrences and a worse outcome.     

Danazol for systemic lupus erythematosus with refractory autoimmune thrombocytopenia or Evans' syndrome

OBJECTIVE: To determine the efficacy of danazol for refractory autoimmune thrombocytopenia or Evans' syndrome complicating systemic lupus erythematosus (SLE). METHODS: We studied 16 consecutive patients with SLE and corticosteroid refractory autoimmune thrombocytopenia; 3 patients had coexisting autoimmune hemolysis (Evans' syndrome). Five patients had undergone splenectomy. Danazol was commenced at 200 mg/day, and increased stepwise (maximum 1200 mg/day) until benefit or toxicity was observed. After remission the danazol dose was gradually reduced to 200-400 mg/day. RESULTS: All 16 patients achieved a complete remission (platelet count >100 x 10(9)/l, hematocrit >39%) 2 months after starting danazol (range 6 weeks-8 months). Remission persisted during continued danazol therapy (mean followup 18.2 months, range 2-49 months). One patient with Evans' syndrome required discontinuation of danazol because of jaundice and biopsy proven minimal hepatic necrosis: hemolysis recurred after discontinuation of danazol. CONCLUSION: Danazol is effective for the treatment of autoimmune thrombocytopenia or Evans' syndrome complicating SLE irrespective of splenectomy status. Longer followup will be needed to determine whether the remission persists after withdrawal of danazol.