Nutritional aspects of neuromuscular diseases

Evidence suggests that individuals with DMD have reduced skeletal development, including decreased linear growth and bone mineral density, compared to normal subjects. Despite their reduced muscle mass, a high percentage of DMD patients are overweight. Body composition measurements can assist with monitoring changes in fat mass and skeletal muscle mass as the disease progresses. Weight management in overweight DMD patients is indicated because excess adiposity burdens mobility and breathing, but only one study in two DMD patients has documented that weight reduction can be done safely. In the latter stages of the disease most DMD subjects become underweight because of an acceleration in skeletal muscle protein degradation relative to its synthesis. Studies of energy, protein and branched chain amino acid supplementation in DMD have yielded promising but inconclusive results, and more well-designed studies are needed in this area. Although there is currently no cure for DMD, studies on the role of nutritional therapy in increasing the quality of life in these patients are urgently needed. Studies in adults with various SP-NMDs indicate a reduction in fat-free mass and an increase in fat mass relative to controls. The newly developed method of air displacement plethysmography for measuring body composition is ideally suited for SP-NMD subjects because it requires very little effort and the measurement procedure is relatively fast. Dual energy x-ray absorptiometry technology has been proposed for distinguishing myogenic from neurogenic SP-NMDs from calculation of the fat-to-lean soft tissue ratio, which is higher in patients with myogenic muscular atrophy. Studies on the energy metabolism of ambulatory SP-NMD subjects indicate that their basal metabolic rate is either similar to or slightly lower than controls, but 24-hour energy expenditure is about 25% lower than controls. This reduction in 24-hour energy expenditure is due to a reduction in physical activity in SP-NMD. Studies examining the roles of energy expenditure, physical activity, and diet in the development of adiposity and risk for secondary chronic diseases in SP-NMD subjects are currently underway.     

Poisson Surface Reconstruction with Envelope Constraints

Reconstructing surfaces from scanned 3D points has been an important research area for several decades. One common approach that has proven efficient and robust to noise is implicit surface reconstruction, i.e. fitting to the points a 3D scalar function (such as an indicator function or signed-distance field) and then extracting an isosurface. Though many techniques fall within this category, existing methods either impose no boundary constraints or impose Dirichlet/Neumann conditions on the surface of a bounding box containing the scanned data. In this work, we demonstrate the benefit of supporting Dirichlet constraints on a general boundary. To this end, we adapt the Screened Poisson Reconstruction algorithm to input a constraint envelope in addition to the oriented point cloud. We impose Dirichlet boundary conditions, forcing the reconstructed implicit function to be zero outside this constraint surface. Using a visual hull and/or depth hull derived from RGB-D scans to define the constraint envelope, we obtain substantially improved surface reconstructions in regions of missing data.     

Use of the Neuropsychiatric Inventory in traumatic brain injury: A pilot investigation.

Objective: The goal of this investigation was to pilot the Neuropsychiatric Inventory (NPI) among individuals with traumatic brain injury (TBI) and their caregivers, assessing its screen-metric approach. Design and Participants: Using the NPI, caregivers rated neurobehavioral disturbances in 51 individuals with moderate-to-severe TBI. The NPI was completed 1 or 2 years after the individuals were injured. Results: Caregivers reported the highest symptom levels for participants on Irritability/Lability, Apathy, and Agitation/Aggression, and rated greater levels of distress tied to those domains and to Dysphoria. Caregivers endorsing domain screening items endorsed significantly more metric items (vs. screen non-endorsers) within that domain, as would be expected if the screen accurately measured the psychopathology under consideration. In addition, the screen-metric yielded extremely low false-positive rates, although 5 of the 12 domains had elevated false-negative rates. Conclusions: Findings provide preliminary support for the accuracy of the NPI's screen-metric in this population and are consistent with prior work detailing common problematic neurobehavioral consequences of TBI. These results lay groundwork for research and clinical use of this measure in populations with TBI. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Liability management or risk management? Evaluation of a Greek System alcohol policy.

The present study is an evaluation of a policy restricting access to alcohol for Greek System members. A cross-sectional comparison of drinking rates and attitudes toward the policy used 994 participants at the implementation of the policy and 1,051 participants 1 year after implementation. Results indicated that drinking per occasion was greater for men and women after the policy was implemented, and, in general, attitudes toward selected policy provisions were more negative. These results suggest that policies designed to manage liability may have unintended consequences related to increased risk. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Review of solid/liquid desiccant in the drying applications and its regeneration methods

Desiccant material has been used in drying applications because of its low energy consumption, among other advantages. Desiccant material can produce hot and dry air that is beneficial for the drying process. The advantages of using desiccant material in a drying system include continuous drying even during off-sunshine hours, increased drying rate due to hot and dry air, more uniform drying, and increased product quality especially for heat-sensitive products. Some problems in desiccant system such as pressure drop in solid desiccant, carry over of liquid desiccant by air stream and low moisture adsorption capacity may be improved by optimization of the design of desiccant system. Numerous researchers have studied the low cost and low regeneration temperature of desiccant material, and the optimization of desiccant application to produce more competitive energy. The use of heat to regenerate desiccant material in a drying system has limitations in energy saving. However the use of low energy or free available energy such as solar energy and waste heat from industrial processes for regeneration of desiccant material will make the system more cost-effective. This paper presents several works on the regenerative method of the desiccant system and its application in the drying system for both solid and liquid desiccant materials.     

Personalized mailed feedback for college drinking prevention: A randomized clinical trial.

The current study was designed to evaluate the efficacy of a mailed feedback and tips intervention as a universal prevention strategy for college drinking. Participants (N = 1,488) were randomly assigned to feedback or assessment-only control conditions. Results indicated that the mailed feedback intervention had a preventive effect on drinking rates overall, with participants in the feedback condition consuming less alcohol at follow-up in comparison with controls. In addition, abstainers in the feedback condition were twice as likely to remain abstinent from alcohol at follow-up in comparison with control participants (odds ratio = 2.02), and feedback participants were significantly more likely to refrain from heavy episodic drinking (odds ratio = 1.43). Neither gender nor severity of baseline drinking moderated the efficacy of the intervention in these analyses, but more conservative analyses utilizing last-observation carryforward suggested women and abstainers benefited more from this prevention approach. Protective behaviors mediated intervention efficacy, with participants who received the intervention being more likely to use strategies such as setting limits and alternating alcohol with nonalcoholic beverages. Implications of these findings for universal prevention of college drinking are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Use of an expert system in a personnel selection process

The purpose of this study was to begin the development and testing of an Expert System (ES) to screen officer personnel records being considered for Command and General Staff College (CGSC). The study included a review of the Artificial Intelligence (AI) literature relevant to the military and human resource management, problem selection, knowledge acquisition, knowledge representation, knowledge encoding, and knowledge testing and evaluation. The AI computer language PROLOG was used to develop a basic rule-based expert system called BOARDEX. Data from mock officer personnel records obtained from U.S. Army Total Personnel Command (PERSCOM) were entered into BOARDEX. Results from BOARDEX were correlated to votes generated by a board consisting of 10 human experts from the U.S. Army War College Class of 1996. The results show that BOARDEX's decisions are not statistically different from the decisions made by human experts.     

Atmospheric particle composition-hygroscopic growth measurements using an in-series hybrid tandem differential mobility analyzer and aerosol mass spectrometer

The ability of atmospheric particles to absorb water has extensive climate, atmospheric chemistry, and health implications, and considerable effort has gone into determining relationships between particle composition and hygroscopicity. Parallel techniques, in which co-located composition and hygroscopicity measurements are combined to infer composition-hygroscopicity relationships, may not detect the influence of external mixtures. Previous in-line measurements have been limited to single-particle composition or a limited analyte range, and are often non-quantitative and/or offline. Here, we present for the first time in-series, online, quantitative hygroscopicity-composition measurements using a Brechtel Manufacturing, Inc. Hybrid Tandem Differential Mobility Analyzer and an Aerodyne High-Resolution Time-of-Flight Aerosol Mass Spectrometer. This technique is first verified using laboratory-generated external particle mixtures, then extended to ambient measurements at a seaside sampling side at the Hong Kong University of Science and Technology. The technique successfully separated laboratory-generated particles of differing hygroscopicities and showed promise for atmospheric particles, though high mass attenuation endemic to the HTDMA dual size selection limits application to environments with at least ～14–41 μg/m³ of particulate mass, depending on composition.

Copyright © 2017 American Association for Aerosol Research     

Dense Point‐to‐Point Correspondences Between Genus‐Zero Shapes

We describe a novel approach that addresses the problem of establishing correspondences between non‐rigidly deformed shapes by performing the registration over the unit sphere. In a pre‐processing step, each shape is conformally parametrized over the sphere, centered to remove Möbius inversion ambiguity, and authalically evolved to expand regions that are excessively compressed by the conformal parametrization. Then, for each pair of shapes, we perform fast SO(3) correlation to find the optimal rotational alignment and refine the registration using optical flow. We evaluate our approach on the TOSCA dataset, demonstrating that our approach compares favorably to state‐of‐the‐art methods.