Love and dating experience in early and middle adolescence: grade and gender comparisons

The experience of being "in love" was studied in a sample of 186 early to middle adolescent males and 199 early to middle adolescent females. Results indicated that amount of dating experience of adolescents varied widely at each age. Being "in love" co-occurred with a reciprocal on-going relationship about half the time. Boys fell in love earlier and more often than girls, and both genders seemed to employ an increasingly narrow prototypical conception of being "in love". Qualitative analyses suggested that early and middle adolescents are actively reasoning about the nature and meaning of romantic feelings and experiences. Results are interpreted from the standpoint of psychosocial developmental theory, and implications for interventions with adolescents are discussed.     

Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography

BACKGROUND: Prior research has suggested reductions in the density of serotonin transporter (SERT) binding sites in blood platelets and post-mortem brain tissue of depressed patients. We sought to determine whether patients with unipolar major depression have diminished SERT availability as assessed by both brainstem [123I] beta-CIT SPECT and platelet [3H]paroxetine binding. METHODS: Drug-free depressed and healthy subjects were injected with 211 +/- 22 MBq [123I] beta-CIT and imaged 24 +/- 2 h later under equilibrium conditions. A ratio of specific to nonspecific brain uptake (V3" = (brainstem-occipital)/occipital), a measure proportional to the binding potential (Bmax/Kd), was used for all comparisons. RESULTS: Results showed a statistically significant reduction in brainstem V3" values in depressed as compared to healthy subjects (3.1 +/- .9 vs. 3.8 +/- .8, p = .02). Platelet [3H]paroxetine binding was not altered (Bmax = 2389 +/- 484 vs. 2415 +/- 538 fmol/mg protein, p = .91) and was not significantly correlated with brainstem [123I] beta-CIT binding (r = -0.14, p = .48). CONCLUSIONS: These data are the first to suggest reductions in the density of brain SERT binding sites in living depressed patients. These findings provide further support for a preeminent role for alterations in serotonergic neurons in the pathophysiology of depression.     

Conformations and folding of lysozyme ions in vacuo

Proton transfer reactivity of isolated charge states of the protein hen egg-white lysozyme shows that multiple distinct conformations of this protein are stable in the gas phase. The reactivities of the 9+ and 10+ charge state ions, formed by electrospray ionization of "native" (disulfide-intact) and "denatured" (disulfide-reduced) solutions, are consistent with values calculated for ions in their crystal structure and fully denatured conformations, respectively. Charge states below 8+ of both forms, formed by proton stripping, have similar or indistinguishable reactivities, indicating that the disulfide-reduced ions fold in the gas phase to a more compact conformation.     

Tests for comparing images based on randomization and permutation methods

Tests comparing image sets can play a critical role in PET research, providing a yes-no answer to the question "Are two image sets different?" The statistical goal is to determine how often observed differences would occur by chance alone. We examined randomization methods to provide several omnibus test for PET images and compared these tests with two currently used methods. In the first series of analyses, normally distributed image data were simulated fulfilling the requirements of standard statistical tests. These analyses generated power estimates and compared the various test statistics under optimal conditions. Varying whether the standard deviations were local or pooled estimates provided an assessment of a distinguishing feature between the SPM and Montreal methods. In a second series of analyses, we more closely simulated current PET acquisition and analysis techniques. Finally, PET images from normal subjects were used as an example of randomization. Randomization proved to be a highly flexible and powerful statistical procedure. Furthermore, the randomization test does not require extensive and unrealistic statistical assumptions made by standard procedures currently in use.     

Spinal neurilemmomas and neurofibromas: central dot sign in postgadolinium MRI

The MR studies of three histologically proven spinal neurilemmomas and neurofibromas were reviewed retrospectively. There were two benign neurilemmomas (schwannomas) and one neurofibroma. The common characteristic of these cases was a central low intensity focus ("dot") seen on postcontrast T1-weighted imaging. The low intensity foci corresponded histologically to a congeries of changes including edema, microcysts, foam cells, hyalinization of blood vessels, old hemorrhage, and dystrophic calcification.     

Chlorpropamide-induced hypoglycemia: successful treatment with diazoxide

A healthy adolescent boy was treated on two occasions for an overdose of chlorpropamide (Diabinese). Glucose therapy alone was not sufficient to control the hypoglycemia, but the administration of glucose plus diazoxide raised the blood sugar to supranormal levels. A bolus of intravenous glucagon briefly raised the blood sugar level to within normal limits, increased the blood ketones but also augmented insulin secretion. An overdose of sulfonylurea may cause prolonged and fatal hypoglycemia. Rational therapy, both in diabetic and normal persons, is glucose plus an "insulin antagonist." The administration of diazoxide was effective in our patient, substantially reducing the plasma insulin level; this agent may be the "insulin-antagonist" of choice for use in sulfonylurea-induced hypoglycemia.     

The metrology of a miniature FT spectrometer MOEMS device using white light scanning interference microscopy

Micro-optical electro-mechanical systems (MOEMS) technology, making use of existing silicon based fabrication techniques shows great potential for making complete miniaturized hybrid devices. Such technology has been used to make a Fourier transform spectrometer based on a time-scanning Michelson interferometer. An electrostatic comb drive actuator moves the scanning mirror over a distance of 40 μm. The measured resolution of the spectrometer is 6 nm at a wavelength of 633 nm. The dimensions of the device are 5×5×0.5 mm, and the depth of feature is 75 μm. During quality control of such devices it is necessary to check the dimensions of micron wide structures that are tens of microns deep, over areas of tens of square millimeters. In this work we have investigated the use of white light scanning interference (WLSI) microscopy for making rapid, non-destructive precision three-dimensional measurements. While a high axial precision can be achieved, an artifact has been observed with classical configurations that tend to extend the location of deep step discontinuities by up to 3 μm and so broaden narrow structures. With certain modifications in the optical configuration, this error can be considerably reduced. The results of this work demonstrate that WLSI shows great potential for the rapid and precise quality control of MOEMS devices.     

Failure of Titanium Condenser Tubes After 24 Years Power Plant Service

The titanium condenser has been in operation for 24 years at Amager unit 3 power plant. In February 2012, the plant was contaminated by seawater due to a failed condenser tube and some tubes were plugged. A month later, the plant tripped again. Small leaks were found again and finally approx. 200 tubes were plugged before the condenser was in service again. A series of inspections, NDT, and destructive examinations were conducted to try and understand the cause of failure in the tubes within the condenser. After such investigations, degradation mechanisms such as inner fouling, steam impingement, and fretting/erosion around the supports could be discounted. Ductile cracks were found in the tube within the tubesheet. From circumstantial evidence, it was concluded that failure was caused by a semi-filled condenser which led to a mismatch in expansion coefficients of filled tubes and unfilled tubes during a plant trip. In addition, small amounts of titanium hydride were revealed to be present in the tubes within the tubesheet indicating that the carbon steel tubesheet was corroding due to ingress of salt water. Although this was not the reason for the failure, it indicated the need for repair of the epoxy coating in the waterbox.