Diels-alder adducts from safflower fatty acids: III. Acrylic and related acid dienophiles

The Diels-Alder adducts from alkali conjugated and elaidinized safflower fatty acids with acrylic, methacrylic, crotonic and cinnamic acids and their esters as dienophiles were obtained in 40–64% yields. Low yields of 16–18% were obtained when 10-undecenoic acid and its ester were used. Most of the adducts could be estimated quantitatively in the reaction products by column chromatography or gas liquid chromatography (GLC). For the estimation of the adducts from crotonic and 10-undecenoic acids a combination of column chromatography and GLC techniques was employed. Partitioning between hexane and 90% methanol, partial esterification with alkali washing, and splitting and fractional distillation under reduced pressure were methods used to obtain the adducts in 90–95% purity.     

Urban Social Media Demographics: An Exploration of Twitter Use in Major American Cities

This article explores intersections between place, race/ethnicity, and gender amongst American Twitter users and makes an argument that studying the intensity of tweets provides insights into how and why particular groups tweet. Given recent events in American political life such as the shooting in Ferguson, Missouri and the reactions by young, urban African Americans on Twitter, understanding the role of race, place, gender, and age is important. We observed the time between tweets of urban American Twitter users and explored whether the medium may be providing traditionally marginalized groups, such as young Black men, with potential avenues for mobilizing communication and access to resources.     

Microstructural development in the directed melt-oxidized (DIMOX) Al-Mg-Si alloys

Metal-ceramic composites produced via directed melt oxidation (DIMOX) of aluminium alloys are of recent interest. Thein situ composite forming method is based on the reaction of a molten alloy with a gaseous oxidant. In the present study, Al-Mg-Si alloys were subjected to directed melt oxidation and the progressive microstructural evolution was examined by interrupted growth experiments. In the early stages, liquid alloy oxidizes to form a duplex oxide layer (MgO+MgAl₂O₄) on the surface. The openings in these oxide layers allow the liquid alloy to wick through to form small nodules on the surface. When further wicking occurs through these nodules, a cauliflower type of colonies is formed. During the early part of the second stage, spinel growth dominates to form a multi-layered structure. In the final stage, as the magnesium reaches low levels, Al₂O₃ formation dominates the growth, and alumina crystals grow continuously for several tens of micrometres. The oxygen required for alumina formation is expected to come from two sources: (i) from the ingress of oxygen through microcracked oxide layers, and (ii) demixing of magnesium-containing oxides in the underneath layers.     

Reproductive health of the family as a goal of industrial medicine

Modern demographic situation stressed the problems of human reproductive health associated with industrial medical topics. The article suggests to regard a family (child and two parents) as a unit under study in industrial medicine. This methodic approach should work in scientific programs reviewing influence of industrial ecology and environmental factors on reproductivity. The authors suggest elaboration of universal strategy for ecologic and epidemiologic studies to form a scientific branch "Epidemiology of reproductive health" and to elaborate methods for better health management during the present demographic crisis.     

Effects of antioxidant state on individual susceptibility to silicosis (an experimental study)

The authors proved that animals having higher natural antioxidant activity and lower intensity of lipid peroxidation are more resistant to fibrogenic effects of quartz. The peritoneal macrophages obtained from those animals show higher resistance to quartz exposure "in vitro". Parameters characterizing antioxidant system should be included into a group of indexes describing propensity to silicosis.     

A nano-plasmonic HMIM waveguide based concurrent dual-band BPF using circular ring resonator

This article analyzes the transmission line characteristics of plasmonic hybrid metal insulator metal (HMIM) waveguide, circular ring resonator (CRR) based dual-band band-pass filters with two transmission poles in both pass-bands in the optical regime using coupled line feed. The transmission line characteristics of an HMIM waveguide, such as characteristic impedance (ZPV), effective refractive index (neff) and propagation length (Lspp), have been obtained by using full wave simulation. Using basic HMIM slot waveguide, a CRR with periodic loading of double- and triple-ring CRR is numerically analyzed. Two input ports have been used for excitation, which are located at the separation of 180° positions along the CRR, and are coupled with the ring by parallel coupled lines, producing the dual pass-bands with the synchronous excitation of two transmission poles. The proposed double-ring dual-band band-pass filter (DR-DB-BPF) offers 35 dB extinction ratio (ER), 299.69 nm free spectral range (FSR) and narrow band full width half maximum (FWHM) of 78.057—112.43 nm. The triple-ring DB-BPF (TR-DB-BPF) has 22.5 dB ER, FSR of 292.18 nm and FWHM of 42.751—59.58 nm. The proposed filters are very useful in the development of dual-band filters for electronic photonic integrated circuits (EPICs), as the optical signals are filtered at two wavelengths simultaneously.     

Secure Key Management Based Mobile Authentication in Cloud

Authentication is important to the security of user data in a mobile cloud environment. Because of the server’s user credentials, it is subject to attacks. To maintain data authentication, a novel authentication mechanism is proposed. It consists of three independent phases: Registration, login, and authentication and key agreement. The user registers with the Registration Center (RC) by producing a secret number that isn’t stored in the phone, which protects against privileged insider attacks. The user and server generate a nonce for dynamic user identity and agree on a session secret key for safe communication. The passwords are not stored on the computer or provided in plain text, they are resistant to replay, guessing, and stolen verification attacks. The suggested protocol uses a one-way hash function and XOR operations, with the client having remote access to a large number of servers over a secure communication channel. Concentrates on HMAC and SHA3 for Collision Free Hashing and to overcome length extension attacks. HMACs are substantially less affected by collisions than their underlying hashing algorithms alone. So adding an HMAC to an MD5 or SHA hash would make it substantially more difficult to break via a rainbow table.     

A mechanistic approach to evaluate the potential of the debonding distress in asphalt pavements

The debonding distress in asphalt pavement structures is a critical problem that affects the performance of asphalt concrete pavements. It occurs at the layer interface due to the poor bond quality between adjacent asphalt concrete layers and/or when stresses at the layer interface exceed the strengths of the material at the interface. The debonding of the adjacent layers, especially the top surface layer of an asphalt pavement, is a contributing factor to the premature cracking of pavements. Hence, the debonding distress can lead to a reduction in the life of the pavement. This paper presents an analytical and experimental framework to evaluate the potential for debonding at the layer interface of asphalt concrete pavements. Computational analysis was performed to determine the critical stress and strain states in layered asphalt pavements under moving vehicle loads using the Layered ViscoElastic pavement analysis for Critical Distresses (LVECD) computer program developed at North Carolina State University. This computational analysis enables a greater understanding of the critical stress that is involved in debonding and the ways that such stress is affected by pavement design parameters and environmental conditions. In addition, a prediction model was developed that can determine the shear bond strength at the interface of asphalt concrete layers with different tack coat materials at various temperatures, loading rates and normal confining stresses. The systematic and mechanistic framework developed in this study employs the maximum shear ratio concept as a shear failure criterion and provides a tool to evaluate the effects of various loading, environmental and pavement factors on the debonding potential of asphalt pavements. The overall advantages of the mechanistic framework and approach using the LVECD analysis tool will help lead to better understanding of the debonding mechanism, proper selection of the tack coats, and economic benefit in highway pavement maintenance and rehabilitation costs.     

Adding precise nanoliter volume capabilities to liquid-handling automation for compound screening experimentation

Miniaturizing experimental sample volumes to the nanoliter volume range is one of the most economical ways to perform mid- and high-throughput compound screening experiments. Existing automation platforms for nanoliter fluid handling can be bulky, expensive, and require periodic calibration to provide consistent liquid dispensing. In addition, even with frequent calibration, significant instrument-to-instrument variation in low-volume dispensing can occur between different instrument platforms. Many of these issues can be addressed by the use of PocketTips. PocketTips are tips with a defined internal pocket designed to hold specific nanoliter volumes of compound dissolved in dimethylsulfoxide. Although the overall liquid-handling process with PocketTips uses the aspirate/dispense features of the specific liquid-handling device being used, the dispensed nanoliter volume is solely based on the dimensions of the pocket of the PocketTip and thus, the liquid-handling device itself need not have nanoliter dispensing capabilities. In this report, we demonstrate the performance of PocketTips on different automation platforms. In addition, we used a cell-based ?-lactamase reporter assay system to demonstrate that compound delivery by PocketTips compares favorably with a standard compound addition technique.     

A finite element alternative to infinite elements

In this paper, a simple idea based on midpoint integration rule is utilized to solve a particular class of mechanics problems; namely static problems defined on unbounded domains where the solution is required to be accurate only in an interior (and not in the far field). By developing a finite element mesh that approximates the stiffness of an unbounded domain directly (without approximating the far-field displacement profile first), the current formulation provides a superior alternative to infinite elements (IEs) that have long been used to incorporate unbounded domains into the finite element method (FEM). In contrast to most IEs, the present formulation (a) requires no new shape functions or special integration rules, (b) is proved to be both accurate and efficient, and (c) is versatile enough to handle a large variety of domains including those with anisotropic, stratified media and convex polygonal corners. In addition to this, the proposed model leads to the derivation of a simple error expression that provides an explicit correlation between the mesh parameters and the accuracy achieved. This error expression can be used to calculate the accuracy of a given mesh a-priori. This in-turn, allows one to generate the most efficient mesh capable of achieving a desired accuracy by solving a mesh optimization problem. We formulate such an optimization problem, solve it and use the results to develop a practical mesh generation methodology. This methodology does not require any additional computation on the part of the user, and can hence be used in practical situations to quickly generate an efficient and near optimal finite element mesh that models an unbounded domain to the required accuracy. Numerical examples involving practical problems are presented at the end to illustrate the effectiveness of this method.