排序方式: 共有96条查询结果,搜索用时 15 毫秒
51.
Nithya Ramesh 《Drug development and industrial pharmacy》2013,39(9):1506-1514
Epigallocatechin-3-gallate (EGCG), derived from green tea, is an active phytochemical against many types of cancer, cardiovascular, neurological and inflammatory diseases. However, its pharmaceutical activity is limited due to low bioavailability and chemical instability. To overcome these limitations, we fabricated spherical, EGCG loaded solid lipid nanoparticles (SLN-EGCG) as an oral delivery system. The SLN-EGCG showed a hydrodynamic diameter of 300.2?±?3.8?nm with the drug encapsulation efficiency of 81?±?1.4%. Additionally, a slow and sustained release of EGCG was noted. Mathematical modeling of release kinetic data suggested that the SLN-EGCG followed the Higuchi model and released EGCG via fickian diffusion method. The data on pharmacokinetic parameters indicated significantly improved bioavailability and protection of EGCG from degradation due to encapsulation into SLN. The SLN-EGCG did not show any acute or sub-chronic toxicity when compared with free EGCG in the rat model. Together these data supported the hypothesis that SLN-EGCG is capable of enhancing the bioavailability and stability of EGCG and can be used as an alternative system for oral administration of EGCG. 相似文献
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V. D. Nithya S. Sharmila Kumaran Vediappan Chang Woo Lee Leonid Vasylechko R. Kalai Selvan 《Journal of Applied Electrochemistry》2014,44(5):647-654
This work emphasizes the structural, morphological, electrical, and electrochemical properties of 0.05 mol Zr- and Si-doped Li4Ti5O12 synthesized using the molten salt method and applied to negative electrodes in Li-ion batteries. Formation of the spinel phase with face-centered cubic structure in the nominally pure and Zr- and Si-doped samples are revealed from X-ray powder diffraction technique. Lattice parameters refined by full-profile Rietveld method are in accordance with the literature data for the Li4Ti5O12 (Li1.333Ti1.667O4) spinel structure. The presence of possible functional groups is identified using Fourier transform infra red spectroscopy. The field emission scanning electron microscopic images indicate the formation of micron-sized (1.5–2 μm) randomly distributed polyhedral-shaped particles. The electrical conductivity studies demonstrate the grain-conducting behavior of the material. The maximum DC conductivity of 2 × 10?5 S cm?1 is observed for Zr-doped Li4Ti5O12 at room temperature. The galvanostatic charge–discharge studies show that Zr-doped Li4Ti5O12 exhibits a high discharge capacity of about 325 mAh g?1 at 0.01 °C, higher than Si-doped Li4Ti5O12 (200 mAh g?1), and also that the cycling stability of Zr-doped Li4Ti5O12 is enhanced. 相似文献
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Shaji Sajmi Kamalakannan Goutham Venkatesh Arumugam Natarajan Gopalakrishnan Tanuj Moses Lamech Dhanapalan Aiswarya Ravindran Krishna Paulpandian Vathsalyan Badri Srinivasan Kannan Dolphin Solomon Govindasamy Nithya Bhagavatula V. R. H. Sastry Ramanathan Sakthirajan 《Hemodialysis international. International Symposium on Home Hemodialysis》2021,25(4):515-522
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Nithya Pandiyan Balaji Murugesan Mayakrishnan Arumugam Dhilipkumar Chinnaalagu Selvam Samayanan Sundrarajan Mahalingam 《Advanced Powder Technology》2021,32(7):2213-2225
In the present work, a facile synthesis was applied for the silver-gold decorated yttrium oxide nanoparticles with the use of Justicia adhatoda (leaves extract) and [BMIM] PF6 (Ionic liquid) as a capping/stabilizing agent. The XRD analysis showed that Ag-Au/Y2O3 nanoparticles have a face-center cubic structure and crystallite size of 30 nm. The Y-O stretching bands were observed in the FT-IR spectrum at 464 to 495 cm?1. The band gap of the silver-gold decorated Y2O3 nanoparticles was estimated as 5.75 eV from the UV-DRS spectrum. In the SEM and TEM images, the morphology of silver-gold/Y2O3 nanoparticles shows a nanoflake-like structure. The presence of silver, gold, yttrium and oxygen of elements has been confirmed by the EDX spectrum. The antibacterial activity of the nanoparticles was evaluated for the Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) bacteria. The anticancer activity was also studied by the human cervical cancer cell line. The silver-gold decorated yttrium oxide nanoparticles revealed an exceptional microbicidal and antitumor activity when compared with yttrium oxide, silver decorated yttrium oxide and gold decorated yttrium oxide. 相似文献
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Vasudha Murlidhar Mina Zeinali Svetlana Grabauskiene Mostafa Ghannad‐Rezaie Max S. Wicha Diane M. Simeone Nithya Ramnath Rishindra M. Reddy Sunitha Nagrath 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(23):4895-4904
Circulating tumor cells (CTCs) are believed to play an important role in metastasis, a process responsible for the majority of cancer‐related deaths. But their rarity in the bloodstream makes microfluidic isolation complex and time‐consuming. Additionally the low processing speeds can be a hindrance to obtaining higher yields of CTCs, limiting their potential use as biomarkers for early diagnosis. Here, a high throughput microfluidic technology, the OncoBean Chip, is reported. It employs radial flow that introduces a varying shear profile across the device, enabling efficient cell capture by affinity at high flow rates. The recovery from whole blood is validated with cancer cell lines H1650 and MCF7, achieving a mean efficiency >80% at a throughput of 10 mL h?1 in contrast to a flow rate of 1 mL h?1 standardly reported with other microfluidic devices. Cells are recovered with a viability rate of 93% at these high speeds, increasing the ability to use captured CTCs for downstream analysis. Broad clinical application is demonstrated using comparable flow rates from blood specimens obtained from breast, pancreatic, and lung cancer patients. Comparable CTC numbers are recovered in all the samples at the two flow rates, demonstrating the ability of the technology to perform at high throughputs. 相似文献
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Wireless Personal Communications - Due to self-organizing and self-configuring nature of multihop adhoc networks, routing is the most challenging task. Zone routing protocol (ZRP) is one of the... 相似文献
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Wireless Personal Communications - This paper deals with the coverage probability analysis of Massive MIMO networks with random topology. Poisson Point Process is a popular stochastic geometry... 相似文献
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Suguna M. Nithya sree V. A. Kaveri R. Hemalatha M. Balamurugan N. B. Sriramkumar D. Dhanaselvam P. Suveetha 《SILICON》2022,14(16):10729-10740
Silicon - A two-dimensional analytical model is proposed in this paper for surface potential and drain current on Triple Material Surrounding Gate Heterojunction Tunnel Field Effect Transistor... 相似文献