Characteristics of PM synchronous motor drives with a trapezoidal EMF

A permanent magnet synchronous motor (PMSM) with nonsinusoidal electromotive force (EMF) generates torque ripple even if the sinusoidal PWM inverter drives the PMSM. A new modified trapezoidal modulating signal for PWM inverter suitable for PMSM drive with nonsinusoidal EMF is proposed in this paper. A new modulating signal for the PMSM drive is determined by the condition of reducing torque ripple of the motor with various trapezoidal EMF. When the PWM inverter using modified trapezoidal modulating signal drives the PMSM having a nonsinusoidal EMF, the torque ripple of the motor can be reduced, the DC link voltage utilization is improved, and reduction of switching loss can be obtained. © 2007 Wiley Periodicals, Inc. Electr Eng Jpn, 159(1): 62–71, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20441     

Relative permittivity and conductivity of water‐treed region in XLPE estimated by an equivalent circuit

By dividing a water‐treed XLPE sheet sample of 1 mm thickness into a nondegraded region and a water‐treed one, relative permittivity and AC conductivity σ_AC2 of the water‐treed region have been estimated using an equivalent circuit. The variation of and σ_AC2 with the length r of the water‐treed region has been discussed based on the Sillars model. It was concluded that the volume fraction of water in the water‐treed layer is in the range from 0.5% to 1.5% for the most‐degraded XLPE sheet, which depends on the ratio of axes of spheroids to which water‐filled voids and channels are compared. It was also concluded that the AC conductivity of water in the water‐treed region ranges from 3 × 10^?3 S/m to 2 × 10^?2 S/m. © 2004 Wiley Periodicals, Inc. Electr Eng Jpn, 148(3): 7–14, 2004; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.10332     

An attempt to stabilize nilvadipine solid dispersion by the use of ternary systems

Firstly, we investigated the physical stability of nilvadipine (NIL)/crospovidone (cl-PVP) solid dispersion during storage (40°C, 75% relative humidity) with powder x-ray diffraction, differential scanning calorimetry (DSC) and dissolution test. These studies indicated that recrystallization occurred during storage and that the dissolution of NIL greatly decreased, compared with that of the initial finding. Secondly, to improve the amorphous form physical stability of NIL, methylcellulose (MC) was added to NIL/cl-PVP solid dispersions as a dispersion carrier and NIL/cl-PVP/MC ternary solid dispersion systems were obtained by the solvent method. Powder x-ray diffraction and DSC studies indicated that the amorphous form physical stability of NIL clearly improved in the NIL/cl-PVP/MC solid dispersion systems during storage. Moreover, the dissolution properties of NIL/cl-PVP/MC solid dispersion systems were characterized by cl-PVP markedly enhancing the dissolution of NIL and MC inhibiting the change of the dissolution of NIL during storage. Finally, we obtained an ideal solid dispersion that was accompanied by a consistently higher rate of dissolution.     

Molecular mechanics and molecular orbital simulations on specific interactions between peroxisome proliferator-activated receptor PPARalpha and plasticizer

Peroxisome proliferator-activated receptor α (PPARα) has various physiological functions such as lipid and glucose metabolism, inflammation and fibrosis in living organisms. Many types of ligand molecules such as phthalate and adipate esters control these physiological functions. In the present study, to elucidate the dependence of PPARα properties on ligand binding, we investigated stable structures and electronic properties for the complexes of PPARα and phthalate as well as adipate esters, which are used as a plasticizer, by molecular simulations based on molecular mechanics and molecular orbital methods. Furthermore, to elucidate the influence of these esters in vivo, we injected them into male mice and observed the change in the expression of PPARα-related enzymes. The comparison between the calculated and observed results indicates that the change in the expression has a correlation with the size of energy gaps between highest occupied and lowest unoccupied molecular orbitals of the complexes with mouse PPARα and esters.     

Quantification of the number of EP3 receptors on a living CHO cell surface by the AFM

The distribution of EP3 receptors on a living cell surface was quantitatively studied by atomic force microscopy (AFM). Green fluorescent protein (GFP) was introduced to the extracellular region of the EP3 receptor on a CHO cell. A microbead was used as a probe to ensure certain contact area, whose surface was coated with anti-GFP antibody. The interactions between the antibodies and GFP molecules on the cell surface were recorded to observe the distribution of the receptors. The result indicated that EP3 receptors were distributed on the CHO cell surface not uniformly but in small patches coincident with immunohistochemical observation. Repeated measurements on the same area of cell surface gave confirmation that it was unlikely that the receptors were extracted from the cell membrane during the experiments. The measurement of single molecular interaction between GFP and the anti-GFP antibody was succeeded on the cell surface using compression-free force spectroscopy. The value of separation work required to break a single molecular pair was estimated to be about 1.5 x 10(-18)J. The number of EP3 receptor on the CHO cell surface was estimated using this value to be about 1 x 10(4) under the assumption that the area of the cell surface was about 5,000 microm(2). These results indicated that the number of receptors on a living cell surface could be quantified through the force measurement by the AFM.     

High‐resolution autostereoscopic 3‐D projection display with a space‐dividing iris‐plane shutter

Abstract— A high‐resolution autostereoscopic 3‐D projection display with a polarization‐control space dividing the iris‐plane liquid‐crystal shutter is proposed. The polarization‐control iris‐plane shutter can control the direction of stereo images without reducing the image quality of the microdis‐play. This autostereoscopic 3‐D projection display is 2‐D/3‐D switchable and has a high resolution and high luminance. In addition, it has no cross‐talk between the left and right viewing zones, a simple structure, and the capability to show multi‐view images.     

Signal-integrity improvement method and its robustness evaluation for VLSI and VLSI-packaging

Nowadays, a GHz frequency signal needs to be propagated on a printed circuit board (PCB) with low distortions. In addition, a higher-frequency signal of 10 GHz or more will also need to be propagated with low distortion in very-large-scale integration (VLSI) in the future. However, signal propagation with low distortion is getting more and more difficult as the frequency increases. In order to solve this problem and to ensure signal integrity, we have proposed a novel transmission line called a “segmental transmission line” (STL). In the STL, a transmission line is divided into multiple segments of individual characteristic impedance. The multiple segments are designed to fix the waveform distortion on the transmission line by solving a combinatorial explosion problem using a genetic algorithm. In a previous article, we have shown the effectiveness of an STL designed for a GHz clock signal in computer simulations. We have also fabricated two scaled-up STL prototypes for a clock signal using real printed circuit boards (PCBs). In this article, we input a random signal by changing its frequency to the scaled-up STL prototype designed for a 150-MHz clock signal. We show that the STL has high robustness to the random signals and the frequency fluctuations, which indicates the generality of the STL technique.     

HIF-1α Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn2+ Accumulation in Inflammatory Synoviocytes

Intracellular free zinc ([Zn²⁺]_i) is mobilized in neuronal and non-neuronal cells under physiological and/or pathophysiological conditions; therefore, [Zn²⁺]_i is a component of cellular signal transduction in biological systems. Although several transporters and ion channels that carry Zn²⁺ have been identified, proteins that are involved in Zn²⁺ supply into cells and their expression are poorly understood, particularly under inflammatory conditions. Here, we show that the expression of Zn²⁺ transporters ZIP8 and ZIP14 is increased via the activation of hypoxia-induced factor 1α (HIF-1α) in inflammation, leading to [Zn²⁺]_i accumulation, which intrinsically activates transient receptor potential ankyrin 1 (TRPA1) channel and elevates basal [Zn²⁺]_i. In human fibroblast-like synoviocytes (FLSs), treatment with inflammatory mediators, such as tumor necrosis factor-α (TNF-α) and interleukin-1α (IL-1α), evoked TRPA1-dependent intrinsic Ca²⁺ oscillations. Assays with fluorescent Zn²⁺ indicators revealed that the basal [Zn²⁺]_i concentration was significantly higher in TRPA1-expressing HEK cells and inflammatory FLSs. Moreover, TRPA1 activation induced an elevation of [Zn²⁺]_i level in the presence of 1 μM Zn²⁺ in inflammatory FLSs. Among the 17 out of 24 known Zn²⁺ transporters, FLSs that were treated with TNF-α and IL-1α exhibited a higher expression of ZIP8 and ZIP14. Their expression levels were augmented by transfection with an active component of nuclear factor-κB P65 and HIF-1α expression vectors, and they could be abolished by pretreatment with the HIF-1α inhibitor echinomycin (Echi). The functional expression of ZIP8 and ZIP14 in HEK cells significantly increased the basal [Zn²⁺]_i level. Taken together, Zn²⁺ carrier proteins, TRPA1, ZIP8, and ZIP14, induced under HIF-1α mediated inflammation can synergistically change [Zn²⁺]_i in inflammatory FLSs.     

A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice

Methionine (Met) is considered the most toxic amino acid in mammals. Here, we investigated biochemical and behavioral impacts of ad libitum one-week feeding of high-Met diets on mice. Adult male mice were fed the standard rodent diet that contained 0.44% Met (1×) or a diet containing 16 graded Met doses (1.2×–13×). High-Met diets for one-week induced a dose-dependent decrease in body weight and an increase in serum Met levels with a 2.55 mM peak (versus basal 53 µM) on the 12×Met diet. Total homocysteine (Hcy) levels were also upregulated while concentrations of other amino acids were almost maintained in serum. Similarly, levels of Met and Hcy (but not the other amino acids) were highly elevated in the cerebrospinal fluids of mice on the 10×Met diet; the Met levels were much higher than Hcy and the others. In a series of behavioral tests, mice on the 10×Met diet displayed increased anxiety and decreased traveled distances in an open-field test, increased activity to escape from water soaking and tail hanging, and normal learning/memory activity in a Y-maze test, which were reflections of negative/positive symptoms and normal cognitive function, respectively. These results indicate that high-Met ad libitum feeding even for a week can induce bipolar disorder-like disease models in mice.     

Analysis of PFC boost converter with soft-switching configuration

This paper proposes use of a lossless snubber with a switching device to perform soft switching, thus not only decreasing switching loss in the device drastically, but also improving the input ac current waveform distortion. Computer simulation results show that the input current waveform of the proposed converter seems to eliminate the third harmonic component. We perform an analysis of the input current waveform and identify the requirements for the elimination of the third harmonic component. We also describe the procedure used to design the parameters of the converter. © 2000 Scripta Technica, Electr Eng Jpn, 133(1): 64–78, 2000