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51.
Masaki Matsubara Yukiko Muraki Noriyuki Hatano Hiroka Suzuki Katsuhiko Muraki 《International journal of molecular sciences》2022,23(22)
Transient receptor potential (TRP) ankyrin repeat 1 (TRPA1), which is involved in inflammatory pain sensation, is activated by endogenous factors, such as intracellular Zn2+ and hydrogen peroxide, and by irritant chemical compounds. The synthetic compound JT010 potently and selectively activates human TRPA1 (hTRPA1) among the TRPs. Therefore, JT010 is a useful tool for analyzing TRPA1 functions in biological systems. Here, we show that JT010 is a potent activator of hTRPA1, but not mouse TRPA1 (mTRPA1) in human embryonic kidney (HEK) cells expressing hTRPA1 and mTRPA1. Application of 0.3–100 nM of JT010 to HEK cells with hTRPA1 induced large Ca2+ responses. However, in HEK cells with mTRPA1, the response was small. In contrast, both TRPA1s were effectively activated by allyl isothiocyanate (AITC) at 10–100 μM. Similar selective activation of hTRPA1 by JT010 was observed in electrophysiological experiments. Additionally, JT010 activated TRPA1 in human fibroblast-like synoviocytes with inflammation, but not TRPA1 in mouse dorsal root ganglion cells. As cysteine at 621 (C621) of hTRPA1, a critical cysteine for interaction with JT010, is conserved in mTRPA1, we applied JT010 to HEK cells with mutations in mTRPA1, where the different residue of mTRPA1 with tyrosine at 60 (Y60), with histidine at 1023 (H1023), and with asparagine at 1027 (N1027) were substituted with cysteine in hTRPA1. However, these mutants showed low sensitivity to JT010. In contrast, the mutation of hTRPA1 at position 669 from phenylalanine to methionine (F669M), comprising methionine at 670 in mTRPA1 (M670), significantly reduced the response to JT010. Moreover, the double mutant at S669 and M670 of mTRPA1 to S669E and M670F, respectively, induced slight but substantial sensitivity to 30 and 100 nM JT010. Taken together, our findings demonstrate that JT010 potently and selectively activates hTRPA1 but not mTRPA1. 相似文献
52.
Daisuke Akahori Naoki Inui Yusuke Inoue Hideki Yasui Hironao Hozumi Yuzo Suzuki Masato Karayama Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Takafumi Suda 《International journal of molecular sciences》2022,23(16)
Pulmonary fibrosis is a progressive and fatal disorder characterized by dysregulated repair after recurrent injury. Destruction of the lung architecture with excess extracellular matrix deposition induces respiratory failure with hypoxia and progressive dyspnea. The impact of hypoxia on pulmonary endothelial cells during pulmonary fibrogenesis is unclear. Using a magnetic-activated cell sorting system, pulmonary endothelial cells were isolated from a mouse model of pulmonary fibrosis induced by intratracheally administered bleomycin. When endothelial cells were exposed to hypoxic conditions, a hypoxia-inducible factor (HIF)-2α protein was detected in CD31- and α-smooth muscle actin (SMA)-positive cells. Levels of plasminogen activator inhibitor 1, von Willebrand factor, and matrix metalloproteinase 12 were increased in endothelial cells isolated from bleomycin-treated mice exposed to hypoxic conditions. When endothelial cells were cultured under hypoxic conditions, levels of fibrotic mediators, transforming growth factor-β and connective tissue growth factor, were elevated only in endothelial cells from bleomycin-treated and not from saline-treated lungs. The increased expression of α-SMA and mesenchymal markers and collagen production in bleomycin- or hypoxia-stimulated endothelial cells were further elevated in endothelial cells from bleomycin-treated mouse lungs cultured under hypoxic conditions. Exposure to hypoxia damaged endothelial cells and enhanced fibrogenesis-related damage in bleomycin-treated pulmonary endothelial cells. 相似文献
53.
54.
Lumisight Table: an interactive view-dependent tabletop display 总被引:1,自引:0,他引:1
Kakehi Y. Iida M. Naemura T. Shirai Y. Matsushita M. Ohguro T. 《Computer Graphics and Applications, IEEE》2005,25(1):48-53
A novel tabletop display provides different images to different users surrounding the system. It can also capture users' gestures and physical objects on the tabletop. The Lumisight Table approach is based on the optical design of a special screen system composed of a building material called Lumisty and a Fresnel lens. The system combines these films and a lens with four projectors to display four different images, one for each user's view. In addition, we need appropriate input methods for this display media. In the current state of the project, we can control computers by placing physical objects on the display or placing our hands over the display. This screen system also makes it possible to use a camera to capture the appearance of the tabletop from inside of the system. Our other main idea is to develop attractive and specialized applications on the Lumisight Table, including games and applications for computer-supported cooperative-work (CSCW) environments. The projected images can be completely different from each other, or partially identical and partially different. Users can share the identical parts as public information, because all users can see it. This article is available with a short video documentary on CD-ROM. 相似文献
55.
Einfluß von imidhydantoinpolymeren auf den reststrom modifizierter metalloxid-halbleitertransistoren
Copolymers containing hydantoin- and imide-groups were prepared using purified materials and applied to the surface of MOSFET (Metal Oxide Semiconductor Field Effect Transistor) in order to amplify the influence of copolymers on semiconductor devices. The influence of the polymers on the residual current of the device was analyzed with respect to impurity content, softening temperature of the polymers, composition ratios etc. It was found that the residual current increases with increasing flowing temperature of the polymer containing only imide groups, and with increasing content of hydantoin groups. 相似文献
56.
Ohguro T. Yamada K. Sugiyama N. Imai S. Usuda K. Yoshitomi T. Fiegna C. Ono M. Saito M. Momose H.S. Katsumata Y. Iwai H. 《Electron Devices, IEEE Transactions on》1998,45(3):717-721
We demonstrated silicon MOSFETs with a counter-doped ultrathin epitaxial channel grown by low-temperature UHV-CVD; this allows the channel region to be doped with boron with high precision. The boron concentration and epitaxial layer thickness can be chosen independently, and so it is easy to adjust the threshold voltage of the buried-channel p-MOSFETs with n-type polysilicon gates. It was confirmed that choosing an ultrathin epitaxial layer at 10 nm leads to suppression of the short-channel effects in buried-channel p-MOSFETs with gate length down to 0.15 μm, while maintaining an appropriate value of threshold voltage 相似文献
57.
To induce degradabilities in polymers in response to environmental conditions, the end-modification reactions of poly(α-methylstyrene) derivatives were carried out. When diphenylphosphine chloride was used as a modifier for the living end of para-substituted PMS, the coupling efficiency was ca. 50%. 2-Phenylallyl halide derivatives such as 2-phenylallyl bromide, 2-(4-tolyl)allyl bromide, and α-trifluoromethylstyrene were found to be suitable end-modification agents. For example, ω-2-phenylallyl PMS was prepared with almost quantitative functionality by the reaction of the living PMS with 2-phenylallyl bromide. In a similar way, ω-3,3-difluoro-2-phenylallyl and ω-2-(4-tolyl)allyl PMS derivatives were synthesized. Based on thermogravimetric analysis, onset of the degradation temperature of the end-modified PMS derivatives decreased in the following order: ω-hydrogen- > ω-3,3-difluoro-2-phenylallyl- > ω-2-phenylallyl- > ω-2-(4-tolyl)allyl-PMS. Actually, the onset temperature of ω-2-(4-tolyl)allyl-PMS derivatives was 50°C lower than that of ω-H-PMS derivatives. These results indicate that the active species is produced effectively at the end unsaturated bond, which initiates the depolymerization of the polymer at rather low temperatures. Ionic degradation of these polymers was also investigated using butyllithium as an anionic initiator and methanesulfonic acid as a cationic initiator. Tendencies similar to the thermal degradation were observed. Therefore, it is concluded that a 2-phenylallyl substituent at the end of the PMS chain induces effective degradation through several mechanisms such as radical, anionic and cationic depolymerization reactions. 相似文献
58.
Tamon Ozaki Noriyuki Ito Shuhei Nakamura Jiro Kawai 《Electrical Engineering in Japan》2003,144(1):12-20
The capacitance C and dielectric dissipation factor tan δ of a water‐treed XLPE sheet sample have been measured under the application of 100 V or 1 kV at 60 Hz. The values of C and tan δ at 1 kV are much larger than those at 100 V. The value of tan δ gradually decreases with the length of exposure to a voltage of 1 kV. On the other hand, C is almost constant versus the exposure time. The results have been discussed on the basis of a model in which filling of channels interconnecting voids by water is taken into account. It has been found that the increase of C and tan δ is caused by the growth of the water‐filled channel region on the application of voltage. The gradual decrease in tan δ with the exposure time is explained by the change in the conductivity of the water‐filled channel region, as a result of which the relaxation time shifts to higher frequencies. © 2003 Wiley Periodicals, Inc. Electr Eng Jpn, 144(1): 12–20, 2003; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.10160 相似文献
59.
60.
This paper proposes a quantum nondemolition measurement of the photon number in a Josephson-junction cavity. Under a current-biased
Josephson junction with small capacitance, the Josephson phase fluctuates quantum-mechanically around its classical value
due to the charging effect, and it couples to the photons in the junction cavity nonlinearly, which is necessary for the quantum
nondemolition measurement. We show that the photon number in the junction cavity can be nondestructively measured by detecting
the fluctuation of Josephson supercurrent through the junction. 相似文献