Iodine content of cattle milk from mountain and coast from Perú

With the objective to establish the cause-effect relationship between a geological area and the iodine content in cattle milk, and to estimate the contribution of milk consumption to the dietary iodine intake, the iodine content in cattle milk from the sierra and the coastal regions of Perú was determined. Milk samples were collected of cows from the three main productive zones of Perú, 62 in Cajamarca, 42 in Arequipa, both in the sierra, and 27 in Lima at the coast. The measurement of iodine was made by the method of Zak, based on the Sandell- Kolthoff reaction. The median values obtained were 24 microg/L in Cajamarca, 34 microg/L in Arequipa, and 170 microg/L in Lima. The median value in the sierra, 26 microg/L, was significantly lower than the one found in the coast. Moreover, while in the former 81% of individual values were below 50 microg/L, in the latter, on the contrary, 77% were above 80 microg/L. These results confirm that the iodine content in cattle milk is related to ecological factors. At the same time, they demonstrate that the iodine content in milk from the sierra is six times lower than in milk from the coast, and also that its consumption does not contribute significantly to satisfy the human physiological requirements of iodine in that zone.     

Proteases to Improve the Mechanical Characteristics of Durable Press Finished Cotton Fabrics

N‐Methylol reagents are conventional crosslinking agents that are still widely used in textile industry to produce crease‐resistant cotton fabrics. In this work serine proteases were used to recover the strength of fabrics, cross‐linked with N‐hydroxymethylacrylamide. Nearly one half of the strength loss of crosslinked cotton fabrics could be restored after protease treatment, while the wrinkle recovery angle (WRA) decreased only slightly. The enzymatic hydrolysis of the amide cross‐links in the durable pressed cellulose was confirmed by FT‐IR analysis and dyeability with an acid dye.

Effect of protease concentration on the tensile strength recovery, WRA and acid dye dyeability at 30 min reaction time.     

Performance evaluation of high‐cis 1,4‐polybutadienes

This article reports the results of a study comparing commercially available high‐cis polybutadiene rubbers (BRs) proceeding from different production technologies and bearing distinct structural characteristics. The microstructure of these polymers was characterized by Fourier transform infrared spectroscopy; molecular weight and polydispersity values were characterized by size exclusion chromatography (SEC). The degree of branching was characterized by SEC and dynamic mechanical rheological testing (RPA 2000). Glass‐transition temperature was characterized by differential scanning calorimetry, and rheological properties were characterized with an oscillating rheometer rubber process analyzer (RPA 2000). Tire tread formulations were prepared with carbon black HAF N‐339 as a reinforcement filler, and we compared the mechanical properties and performance of the different elastomer compositions. The compositions were characterized by their rheological properties, tensile resistance, resistance to abrasion, resistance to tearing, permanent deformation, resilience, and fatigue properties. The tested compositions obtained from BRs with distinct structural characteristics showed different performances. Neodymium‐salt‐based catalysts produced BRs with higher cis‐1,4 levels and higher linearities. These polymer compositions also showed higher performances in abrasion resistance, fatigue resistance, and resilience tests. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 88–99, 2006     

Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase

4‐Anilinoquinolines were identified as potent and narrow‐spectrum inhibitors of the cyclin G associated kinase (GAK), an important regulator of viral and bacterial entry into host cells. Optimization of the 4‐anilino group and the 6,7‐quinoline substituents produced GAK inhibitors with nanomolar activity, over 50 000‐fold selectivity relative to other members of the numb‐associated kinase (NAK) subfamily, and a compound (6,7‐dimethoxy‐N‐(3,4,5‐trimethoxyphenyl)quinolin‐4‐amine; 49 ) with a narrow‐spectrum kinome profile. These compounds may be useful tools to explore the therapeutic potential of GAK in prevention of a broad range of infectious and systemic diseases.     

Cytotoxic Activity and Structure–Activity Relationship of Triazole‐Containing Bis(Aryl Ether) Macrocycles

Cancer continues to be a worldwide health problem. Certain macrocyclic molecules have become attractive therapeutic alternatives for this disease because of their efficacy and, frequently, their novel mechanisms of action. Herein, we report the synthesis of a series of 20‐, 21‐, and 22‐membered macrocycles containing triazole and bis(aryl ether) moieties. The compounds were prepared by a multicomponent approach from readily available commercial substrates. Notably, some of the compounds displayed interesting cytotoxicity against cancer (PC‐3) and breast (MCF‐7) cell lines, especially those bearing an aliphatic or a trifluoromethyl substituent on the N‐phenyl moiety (IC₅₀<13 μm ). Additionally, some of the compounds were able to induce apoptosis relative to the solvent control; in particular, (Z)‐N‐cyclohexyl‐7‐oxo‐6‐[4‐(trifluoromethyl)phenyl]‐1¹H‐3,10‐dioxa‐6‐aza‐1(4,1)‐triazola‐4(1,3),9(1,4)‐dibenzenacyclotridecaphane‐5‐carboxamide ( 12 f ) was the most potent in this regard (22.7 % of apoptosis).     

MoS2/Ti low-friction coating for gears

The applicability of a multilayer composite surface coating in gears is discussed in this work, mainly in what concerns to gear efficiency at normal operating conditions and to scuffing load capacity. The average friction coefficient between gear teeth is discussed and compared with uncoated steel gears.The disulfide molybdenum/titanium (MoS₂/Ti) composite coating is studied and the deposition procedure is described.Several screening tests, like Rockwell indentations, ball cratering, pin-on-disc and reciprocating wear, were performed to evaluate the adhesion to the substrate, the tribological performance of this coating and his applicability in heavy loaded rolling-sliding contacts, such as found in gears.FZG gear efficiency tests were performed using type C gears in order to evaluate the influence of the surface coating in gear efficiency, for a wide range of operating conditions. These tests in conjunction with a numerical model for the energetic balance of the FZG gearbox allowed the determination of the average friction coefficient between gear teeth, taking into account the presence of the surface coating.FZG gear scuffing tests were also performed using type C gears in order to evaluate the coating anti-scuffing performance, which proved to be very significant.     

Development of composite membrane PBAT: Zeolite Y for application as rhynchophorol release system

Composite membranes consisting of biodegradable poly(butylene adipate‐co‐terephthalate (PBAT) and zeolite Y (0–10 wt %) were produced by extrusion. Zeolite Y is well dispersed in the membrane up to 5 wt %, but tends to agglomerate at higher contents. The presence of zeolite Y in the composite resulted in an improvement of the thermal stability, mechanical properties, and increased the barrier properties. The interaction of the composite membranes with rhynchophorol was investigated by different techniques, showing that the semiochemical progressively lixiviates PBAT monomers, causing thermal and mechanical properties to decrease. However, no interaction seemed to occur between the rhynchophorol and the zeolite. Studies of diffusion of pheromone through membranes have shown that the addition of the zeolite Y has not contributed significantly to a decrease in the release rate of rhynchophorol, but the presence of the zeolite Y helps to increase chemical, mechanical, and thermal stabilities of the membranes. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 45757.     

Analysis of the foaming mechanisms of materials based on high‐density polyethylene (HDPE) crosslinked with different irradiation doses

Different crosslinked high‐density polyethylene based cellular polymers have been produced by a free foaming process using a chemical blowing agent. The polymer matrix was crosslinked by electron beam irradiation using different doses ranging from 25 to 175 kGy. The main aim of this work is to study the effect of the different irradiation doses on the density, cellular structure, and foaming mechanisms. Results show that irradiation doses as high as 175 kGy have to be used to obtain cellular materials with a low relative density (0.06), cell sizes of around 50 μm, and cell densities of 1.6 × 10⁷ cells cm^?3. The strain hardening of the polymer matrix increases with the irradiation dose leading to an increase of the polymer resistance to be stretched, which helps to avoid undesirable cellular degeneration processes. Irradiation doses lower than 175 kGy are not able to stabilize the cellular structure leading to foams with relative densities higher than 0.1 and degenerated cellular structures. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 46276.     

The Expression of Lipoprotein Receptors Is Increased in the Infarcted Area After Myocardial Infarction Induced in Rats With Cardiac Dysfunction

Left ventricular (LV) remodeling after myocardial infarction constitutes the structural basis for ventricular dysfunction and heart failure. The characterization underlying the expression of lipoprotein receptors in cardiac dysfunction is scarcely explored. The aim of this study was to analyze the status of lipoprotein receptors on the infarcted and noninfarcted areas of LV and to verify whether nanoparticles that mimic the lipid structure of low‐density lipoprotein (LDL) and have the ability to bind to LDL receptors (LDE) are taken up more avidly by the noninfarcted LV. 13 male Wistar rats with left coronary artery ligation (myocardial infarction [MI]) and 12 animals with SHAM operation (SHAM) were used in this study. 6 weeks after the procedure, the quantification of low‐density lipoprotein receptor (LDLR), LDL receptor‐related protein 1 (LRP1), scavenger receptor‐class B type I (SR‐BI) lipoprotein receptors, and PCNA proliferation marker, and tissue uptake of radioactively labeled LDE were performed. Immunohistochemistry and Western blot analysis showed that LDLR, LRP1, SR‐BI, and PCNA, expression in infarcted area of MI was remarkably higher than SHAM and noninfarcted subendocardial (SEN) and interstitial (INT) areas. In addition, in SEN noninfarcted area of MI, the presence of LDLR was about threefold higher than in SHAM SEN and INT noninfarcted areas. The LDE uptake of noninfarcted LV of MI group was about 30% greater than that of SHAM group. In conclusion, these findings regarding the status of lipoprotein receptors after MI induction could help to establish mechanisms on myocardial repairing. In conclusion, infarcted rats with LV dysfunction showed increased expression of lipoprotein receptors mainly in the infarcted area.