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991.
The mechanisms of apical (AP) uptake of cephalexin (CEPH) and loracarbef (LOR) in the absence or presence of an (extemally imposed) proton gradient were determined using well-stirred diffusion chambers that minimize the effects of the unstirred water layer. The results indicated that, compared to AP uptake in the presence of an imposed proton gradient, AP uptake in the absence of an imposed proton gradient had higher K(m) values and lower Jmax values. Furthermore, when inhibition studies were performed in the absence of a proton gradient, only natural peptides were effective, whereas the peptide analogs (e.g., enalapril) were not. In addition to the effects of concentration and competitive inhibitors, the results also indicated that (1) the AP uptake of both drugs was decreased more than 60% by FCCP, regardless of whether the proton gradient was present or absent; (2) effects of protein kinase C promoter were dependent upon the presence of a proton gradient; and (3) AP uptake in the presence of an imposed proton gradient was not affected by feeding restriction, whereas AP uptake in the absence of an imposed proton gradient was. These results showed for the first time that two substrates with similar AP uptake characteristics in the presence of an imposed proton gradient may not share those characteristics in the absence of an imposed proton gradient. Taken together, these results suggest that the AP uptake component that functions in the absence of an imposed proton gradient is distinctly different from the one that functions in the presence of an imposed proton gradient. Data generated from the present study and those in the literature lend support to the hypothesis that this distinctive component represents the second binding site on the AP peptide transporter. However, an alternative hypothesis that there are two AP peptide transporters remains to be disapproved. 相似文献
992.
五强溪水电站主体工程混凝土浇筑垂直运输在大坝两岸分高、低层布置4台平移式20t缆索起重机。其中2台高缆从德国引进,属世界上首次采用全遥控的缆机,同时也是国内塔架最高的缆机;2台低缆属我国目前自行设计制造安装的规格最大、速度最高的缆机。 相似文献
993.
The three-dimensional axisymmetric elastodynamic response of a penny-shaped crack embedded in an infinite elastic solid subjected to a pair of transient concentrated forces is investigated. The forces are applied on the symmetry axis perpendicular and symmetric to the crack surfaces, including the special case when the forces act precisely on the crack surfaces. A time-domain boundary integral equation method is applied for computing the crack-opening displacement and subsequently the time dependence of the dynamic stress intensity factors. Numerical calculations are carried out for various geometry parameters and the results are discussed. It is found that the location of the applied concentrated forces inducing the highest dynamic stress intensity factors differs from that producing the highest static values. 相似文献
994.
The microstructure development of Pd77.5Au6Si16.5 alloy droplet solidified in a drop tube process was studied. It was found that two distinct microstructures, i.e. (Pd,Au)3Si primary phase and Pd+(Pd,Au)3Si eutectic can be obtained when the droplet diameter is within the range between 2.3~0.4 mm. The morpologies of the (Pd,Au)3Si developed from dendrite trunk-like with single branching only into dendrite cluster-like with ternary branching with the decrease of the droplet diameter. When the droplet diameter is about 0.25 mm, the primary phase (Pd,Au)3Si almost disappears and the microstructure mainly shows Pd+(Pd,Au)3Si eutectic. The morphology of the eutectic transforms from fiber-like to plate-like with the decrease of the droplet diameter in the range between 2.3-0.25 mm. When the droplet diameter is about 0.19 mm, the microstructure is only the single phase of Pd solid solution 相似文献
995.
The communicating finite state machines can exchange messages over bounded FIFO channels. In this paper, a new technique, called reverse reachability analysis, is proposed to detect deadlocks on the communication between the communicating finite state machines. The technique is based on finding reverse reachable paths starting from possible deadlock states. If a reverse reachable path can reach the initial global state, then deadlock occurs. Otherwise the communication is deadlock-free. The effectiveness of the technique has been verified by some real protocols such as a specification of X.25 call establishment/clear protocol and Bartlet's alternating bit protocol. 相似文献
996.
Novel algorithmic features of multimedia applications and advances in VLSI technologies are driving forces behind the new multimedia signal processors. We propose an architecture platform which could provide high performance and flexibility, and would require less external I/O and memory access. It is comprised of array processors to be used as the hardware accelerator and RISC cores to be used as the basis of the programmable processor. It is a hierarchical and scalable architecture style which facilitates the hardware-software codesign of multimedia signal processing circuits and systems. While some control-intensive functions can be implemented using programmable CPUs, other computation-intensive functions can rely on hardware accelerators.To compile multimedia algorithms, we also present an operation placement and scheduling scheme suitable for the proposed architectural platform. Our scheme addresses data reusability and exploits local communication in order to avoid the memory/communication bandwidth bottleneck, which leads to faster program execution. Our method shows a promising performance: a linear speed-up of 16 times can be achieved for the block-matching motion estimation algorithm and the true motion tracking algorithm, which have formed many multimedia applications (e.g., MPEG-2 and MPEG-4). 相似文献
997.
999.
几何设计约束的表示与满足问题研究 总被引:3,自引:1,他引:2
对于智能CAD系统来说,具有解决几何设计约束的功能是重要的。本文提出了一种面向对象的几何设计约束表示方法,它可以通过两种方式来表达。文中给出了一个约束传播算法,用于解决约束满足问题。 相似文献
1000.
本文采用离散滑模变结构控制方法,针对机器人提出了一种滑模变结构——PI控制方案,给出了该控制方案滑模存在条件及控制器设计方案。该控制器将离散滑模变结构控制和PI控制两者的优点有机地结合起来,理论分析和仿真结果表明该控制器能使机器人在各种复杂非线性动力学情况下具有良好的性能指标。这种控制器输出切换小,可以投入应用。 相似文献