Fatal interstitial pulmonary disease in a patient with dyskeratosis congenita after allogeneic bone marrow transplantation

Local control rate by radical radiation therapy was analyzed in 33 patients with a piriform sinus cancer. Twenty-five patients (76%) were in stage T3 + T4. Local recurrence-free survival at 3 years was 49% in T1 + T2 and 25% in T3 + T4 (p = 0.01). In T1 + T2 lesions, a biologically effective dose for an acute reaction over 80 Gy and total treatment time less than 70 days appeared to improve local control. In T3 + T4 lesions, good radiation response assessed by the regaining of laryngeal mobility affected local control favorably. An esophageal involvement and destruction of the laryngeal cartilage as well as soft tissue extension precluded the possibility of local control by radiation therapy alone. In addition to the T-stage, other tumor factors should also be considered for predicting local control with radiation therapy.     

High-throughput of DNA sequencing by automated machines

I describe recent advance of DNA sequencing technology including automated machines. The human genome project, particularly large-scale DNA sequencing, forces us to handle numbers of samples simultaneously and rapidly. This lead us to develop new technologies. I herein introduce current progress of sequencing technologies and automated machines.     

Proposal of new iterative scheme in GMRES

In the paper, GMRES is applied to various large matrices appearing in 3D field analyses. By changing the condition of the matrices, effective preconditioning of the matrix is sought. Also studied is a relationship between the residual norm and the precision evaluated during GMRES. The paper shows that the residual norm, which is indirectly computed in GMRES and has so far been used as a measure of precision, cannot be used as an indicator of the solution's accuracy. After discussing deterioration of precision, GMRES(m1), which solves matrices with a modified iterative scheme, is proposed. It is to be confirmed that GMRES(m1) is faster and more accurate than any of GMRES and its modified version, GMRES(m). © 1998 Scripta Technica, Electr Eng Jpn, 123(4): 15–24, 1998     

Reliability of AllnAs/lnGaAs/lnP HEMT with WSi ohmic contacts

We have investigated the degradation mechanism of Al_0.48In_0.52As/In_0.53Ga_0.47As/ InP high electron mobility transistors (HEMTs) using WSi ohmic electrodes. Cross-sectional transmission electron microscopy (TEM) observation and en-ergy dispersive x-ray (EDX) analysis reveal impurities diffusion of gate electrode (titanium: Ti) and fluorine (F) in the AlInAs layer after a high temperature (T_a = 170°C operating life test for 500 h. The decrease of drain current (I_ds) during life test shows linear dependence on square root of aging time. It suggests that the degradation is controlled by a diffusion mechanism. Hence, the estimated degradation mechanism of this device is related with decrease of carrier concentration in the epitaxial layer by these diffused impurities. On the other hand, TEM and EDX show no degradation of WSi/InGaAs interface after aging. Therefore, the WSi electrode for this type of HEMT demonstrates excellent high stability under the accelerated operating life test.     

Acoustic phonon modulation and electron�Cphonon interaction in?semiconductor slabs and nanowires

The acoustic phonon modulation (confinement) in semiconductor nanostructures and their interaction with electrons are reviewed. Special emphasis will be placed on free-standing and layered slabs, as well as nanowires. Analysis includes acoustic phonon dispersion relations, displacement wave functions, amplitudes, form factor, electron-phonon scattering rate, and electron mobility.     

Development of silicon wafer packaging technology for deep UV LED

This paper reports a deep‐ultraviolet LED (deep‐UV‐LED) package based on silicon MEMS process technology (Si‐PKG). The package consists of a cavity formed by silicon crystalline anisotropic etching, through‐silicon vias (TSVs) filled with electroplated Cu, bonding metals made of electroplated Ni/AuSn and a quartz lid for hermetic sealing. A deep‐UV LED die is directly mounted in the Si‐PKG by AuSn eutectic bonding without a submount. It has advantages in terms of size, heat dissipation, light utilization efficiency, productivity and cost over conventional AlN ceramic packages. We confirmed a light output of 30 mW and effective reflection on Si (111) cavity slopes in the Si‐PKG. Based on simulation, further improvement of the optical output is expected by optimizing DUV‐LED die mount condition.     

First plasma experiment on spherical tokamak device UTST

The UTST (University of Tokyo Spherical Tokamak) device was constructed for the purpose of exploring the formation of ultrahigh‐beta ST (spherical tokamak) plasma using the double null plasma merging method. When two plasmas merge together to form a single plasma, magnetic field lines reconnect, and magnetic field energy is converted to plasma kinetic energy, increasing the plasma beta. Merging start‐up has been demonstrated in the TS‐3/4, START, and MAST devices using coils inside the vacuum vessel, and the TS‐3 plasma obtained a 50% beta. In order to demonstrate start‐up in a more reactor‐relevant situation, UTST has all poloidal field (PF) coils outside the vacuum vessel. The first plasma experiment on the UTST was begun in December 2007. In the results, the plasma obtained 10 kA by using only the outer PF coils and a single ST was generated in the lower area (z = –0.3 to –1.0 m) close to a washer gun. This result suggests that another washer gun on the top of the UTST can allow the generation of ST in the upper area and merging start‐up by using outer PF coils. © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 179(2): 20–26, 2012; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.21216     

Oral Squamous Cell Carcinoma Contributes to Differentiation of Monocyte-Derived Tumor-Associated Macrophages via PAI-1 and IL-8 Production

Tumor-associated macrophages (TAMs) promote cancer cell proliferation and metastasis, as well as anti-tumor immune suppression. Recent studies have shown that tumors enhance the recruitment and differentiation of TAMs, but the detailed mechanisms have not been clarified. We thus examined the influence of cancer cells on the differentiation of monocytes to TAM subsets, including CD163⁺, CD204⁺, and CD206⁺ cells, in oral squamous cell carcinoma (OSCC) using immunohistochemistry, flow cytometry, and a cytokine array. Furthermore, we investigated the effect of OSCC cells (HSC-2, SQUU-A, and SQUU-B cells) on the differentiation of purified CD14⁺ cells to TAM subsets. The localization patterns of CD163⁺, CD204⁺, and CD206⁺ in OSCC sections were quite different. The expression of CD206 on CD14⁺ cells was significantly increased after the co-culture with OSCC cell lines, while the expressions of CD163 and CD204 on CD14⁺ cells showed no change. High concentrations of plasminogen activator inhibitor-1 (PAI-1) and interleukin-8 (IL-8) were detected in the conditioned medium of OSCC cell lines. PAI-1 and IL-8 stimulated CD14⁺ cells to express CD206. Moreover, there were positive correlations among the numbers of CD206⁺, PAI-1⁺, and IL-8⁺ cells in OSCC sections. These results suggest that PAI-1 and IL-8 produced by OSCC contribute to the differentiation of monocytes to CD206⁺ TAMs.