Investigating the experience of repossession: A Swedish example

In the beginning of the 1980s, the recession in the Swedish economy increased the risks involved in home ownership and a growing number of households were forced into foreclosures. As very little was known in Sweden about housing repossession at that time, an exploratory study was initiated in 1987 with the purpose of examining the experiences of foreclosure, especially from the house owner's point of view. The County of Gävleborg was chosen as the location of the study, where 103 single‐family houses were repossessed between 1984 and 1986. Telephone interviews were made with women and men in one‐third of the households. A methodological discussion of how to investigate peoples’ experiences of repossession is presented and arguments offered for why a qualitative approach is convenient in this case. Three examples of how foreclosure may be initiated are discussed. The distressing experience of having one's home repossessed is related to the discussion of gender and home ownership evident in battles among spouses over household expenses. Finally, interpretations of various outcomes of the crises are discussed.     

A fast method for robust principal components with applications to chemometrics

When faced with high-dimensional data, one often uses principal component analysis (PCA) for dimension reduction. Classical PCA constructs a set of uncorrelated variables, which correspond to eigenvectors of the sample covariance matrix. However, it is well-known that this covariance matrix is strongly affected by anomalous observations. It is therefore necessary to apply robust methods that are resistant to possible outliers.

Li and Chen [J. Am. Stat. Assoc. 80 (1985) 759] proposed a solution based on projection pursuit (PP). The idea is to search for the direction in which the projected observations have the largest robust scale. In subsequent steps, each new direction is constrained to be orthogonal to all previous directions. This method is very well suited for high-dimensional data, even when the number of variables p is higher than the number of observations n. However, the algorithm of Li and Chen has a high computational cost. In the references [C. Croux, A. Ruiz-Gazen, in COMPSTAT: Proceedings in Computational Statistics 1996, Physica-Verlag, Heidelberg, 1996, pp. 211–217; C. Croux and A. Ruiz-Gazen, High Breakdown Estimators for Principal Components: the Projection-Pursuit Approach Revisited, 2000, submitted for publication.], a computationally much more attractive method is presented, but in high dimensions (large p) it has a numerical accuracy problem and still consumes much computation time.

In this paper, we construct a faster two-step algorithm that is more stable numerically. The new algorithm is illustrated on a data set with four dimensions and on two chemometrical data sets with 1200 and 600 dimensions.     

Unlocking the potential of pasting properties to predict extrudate characteristics of corn grits blends with high amylose corn starch,potato starch,or rice flour

The development of new production lines of extruded ready-to-eat (RTE) snacks often results in high losses of edible food due to the trial-and-error approach in industry. Being able to predict extrudate characteristics of new formulations before having to run trials on industrial scale would be beneficial for reducing waste and having a more efficient development process. With this study, the correlation between pasting properties of seven blends of flours/starches and extrudate characteristics was investigated (100% corn grits, 25% and 50% replacement of corn grits with high amylose starch, potato starch, and rice flour). The predictive power of pasting characteristics on extrudate's moisture content, water absorption and solubility index, sectional expansion index (SEI) and hardness was studied. Results indicated the potential of predicting SEI, water solubility index (WSI), and water absorption index (WAI) of RTE-snacks. WSI and WAI were, respectively, negatively correlated with peak temperature (R² = 0.897), and positively with peak temperature and positively with trough viscosity (R² = 0.855). One can conclude that the rheometer can be a useful tool to gain insight into the characteristics of the extrudate, although further research with enlargement of the dataset is necessary to make the rheometer effectively deployable for potentially other extrudate characteristics.     

Stem Cell Therapy for Sequestration of Traumatic Brain Injury-Induced Inflammation

Traumatic brain injury (TBI) is one of the leading causes of long-term neurological disabilities in the world. TBI is a signature disease for soldiers and veterans, but also affects civilians, including adults and children. Following TBI, the brain resident and immune cells turn into a “reactive” state, characterized by the production of inflammatory mediators that contribute to the development of cognitive deficits. Other injuries to the brain, including radiation exposure, may trigger TBI-like pathology, characterized by inflammation. Currently there are no treatments to prevent or reverse the deleterious consequences of brain trauma. The recognition that TBI predisposes stem cell alterations suggests that stem cell-based therapies stand as a potential treatment for TBI. Here, we discuss the inflamed brain after TBI and radiation injury. We further review the status of stem cells in the inflamed brain and the applications of cell therapy in sequestering inflammation in TBI.     

Evaluation of the enzyme-linked immunosorbent assay for the rapid screening and detection of classical swine fever virus antigens in the blood of pigs

A workshop was convened, at which seven enzyme-linked immunosorbent assays (ELISAs) were compared with virus isolation for the detection of viraemia in serial blood samples collected from six pigs at up to fourteen days after inoculation with classical swine fever virus. All ELISAs were of the double antibody sandwich type, using monoclonal and/or polyclonal antibodies to detect a variety of viral proteins in leukocytes, or in anti-coagulated blood or serum. Compared to virus isolation, specificity of the ELISA was good: only one sample found negative by virus isolation yielded a positive result in a single ELISA. Some false-negative results occurred with samples collected at up to eight days after inoculation, but all tests found samples collected between nine and fourteen days post-inoculation to be positive. The ELISAs require less-specialised facilities and can be performed much more rapidly than virus isolation. They are therefore extremely promising tools for screening large numbers of live pigs.     

Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator

Cardiac disease is the commonest cause of death amongst diabetic patients. Diabetic cardiomyopathy, which has a poor prognosis, is characterized by left ventricular hypertrophy and impaired cardiac function and mitochondrial damage is said to contribute to its development. We recently showed that treatment with the Cu(II) -selective chelator, triethylenetetramine (TETA), improved cardiac structure, and function in diabetic subjects without modifying hyperglycemia. Thus, TETA has potential utility for the treatment of heart disease. To further understand the molecular mechanism by which it causes these effects, we have conducted the first study of the effect of oral TETA on protein abundance in the cardiac left ventricle of rats with severe streptozotocin-induced diabetes. Proteomic methods showed that of 211 proteins changed in diabetes, 33 recovered after treatment. Through MS, 16 proteins were identified which may constitute major targets of drug action. Remarkably, most of these were mitochondrial proteins with roles in energy metabolism. In addition to components of the mitochondrial respiratory chain and enzymes involved in fatty acid oxidation, TETA treatment normalized both myocardial expression and enzymatic activity of carnitine palmitoyltransferase 2. These findings indicate that mitochondria constitute major targets in the mechanism by which TETA restores cardiac structure and function in diabetes.