The role of numerical simulation for the development of an advanced HIFU system

High-intensity focused ultrasound (HIFU) has been used clinically and is under clinical trials to treat various diseases. An advanced HIFU system employs ultrasound techniques for guidance during HIFU treatment instead of magnetic resonance imaging in current HIFU systems. A HIFU beam imaging for monitoring the HIFU beam and a localized motion imaging for treatment validation of tissue are introduced briefly as the real-time ultrasound monitoring techniques. Numerical simulations have a great impact on the development of real-time ultrasound monitoring as well as the improvement of the safety and efficacy of treatment in advanced HIFU systems. A HIFU simulator was developed to reproduce ultrasound propagation through the body in consideration of the elasticity of tissue, and was validated by comparison with in vitro experiments in which the ultrasound emitted from the phased-array transducer propagates through the acrylic plate acting as a bone phantom. As the result, the defocus and distortion of the ultrasound propagating through the acrylic plate in the simulation quantitatively agree with that in the experimental results. Therefore, the HIFU simulator accurately reproduces the ultrasound propagation through the medium whose shape and physical properties are well known. In addition, it is experimentally confirmed that simulation-assisted focus control of the phased-array transducer enables efficient assignment of the focus to the target. Simulation-assisted focus control can contribute to design of transducers and treatment planning.     

关于社会声学研究的回顾

社会声学概念的明确提出是本世纪初的事情，尽管关于这方面的研究由来已久。通过回顾系统介绍了社会声学研究内容的变迁和研究方法改进的历程，明确了社会声学所面临的问题和应承担的使命。希望这篇综述能够对我国社会声学基础性研究提供新的借鉴和研究思路。     

Synthesis of a linearly interpolated gain scheduling controller for large flexible spacecraft ETS-VIII

This paper illustrates a design procedure for a linearly interpolated gain scheduling controller for Engineering Test Satellite VIII (ETS-VIII) using its linear parameter-varying (LPV) model. The LPV model here consists of piecewise-linear functions of the paddle rotation angle and a norm-bounded perturbation. The main purpose of this research is to derive a simple structured scheduling law that can be easily implemented in a satellite onboard computer. The derived gain has only two grid points and is scheduled simply by linear interpolation, which is desirable from the standpoint of implementability. Moreover, since the synthesis condition is based on parameter-dependent Lyapunov functions, it gives less conservative results than existing methods. Simulation results are presented to show the effectiveness of the proposed synthesis.     

An FPGA implementation of real-time K-means clustering for color images

K-means clustering is a very popular clustering technique, which is used in numerous applications. In the k-means clustering algorithm, each point in the dataset is assigned to the nearest cluster by calculating the distances from each point to the cluster centers. The computation of these distances is a very time-consuming task, particularly for large dataset and large number of clusters. In order to achieve high performance, we need to reduce the number of the distance calculations for each point efficiently. In this paper, we describe an FPGA implementation of k-means clustering for color images based on the filtering algorithm. In our implementation, when calculating the distances for each point, clusters which are apparently not closer to the point than other clusters are filtered out using kd-trees which are dynamically generated on the FPGA in each iteration of k-means clustering. The performance of our system for 512 × 512 and 640 × 480  pixel images (24-bit full color RGB) is more than 30 fps, and 20–30 fps for 756 × 512 pixel images in average when dividing to 256 clusters.

Two-group interfacial area transport equations at bubbly-to-slug flow transition

In relation to nuclear reactor accident and safety studies, experiments on hot-leg U-bend two-phase natural circulation in a loop with a relatively large diameter pipe (10.2 cm inner diameter) were performed for understanding the two-phase natural circulation and flow termination during a small break loss of coolant accident in LWRs. The loop design was based on the scaling criteria developed under this program and the loop was operated either in a natural circulation mode or in a forced circulation mode using nitrogen gas and water. Various tests were carried out to establish the basic mechanism of the flow termination as well as to obtain essential information on scale effects of various parameters such as the loop frictional resistance, thermal center and pipe diameter. The void distribution in a hot-leg, flow regime and natural circulation rate were measured in detail for various conditions. The termination of the natural circulation occurred when there was insufficient hydrostatic head in the downcomer side. The superficial gas velocity at the flow termination could be predicted well by the simple model derived from a force balance between the frictional pressure drop along the loop and the hydrostatic head difference. The bubbly-to-slug flow transition was found to be dependent on axial locations. It turned out that the formation of cap bubbles in the large diameter pipe caused the increased drift velocity, which would affect the prediction of the void fraction in the hot leg.     

Sar1 Affects the Localization of Perilipin 2 to Lipid Droplets

Lipid droplets (LDs) are intracellular organelles that are ubiquitous in many types of cells. The LD core consists of triacylglycerols (TGs) surrounded by a phospholipid monolayer and surface proteins such as perilipin 2 (PLIN2). Although TGs accumulate in the phospholipid bilayer of the endoplasmic reticulum (ER) and subsequently nascent LDs buds from ER, the mechanism by which LD proteins are transported to LD particles is not fully understood. Sar1 is a GTPase known as a regulator of coat protein complex Ⅱ (COPⅡ) vesicle budding, and its role in LD formation was investigated in this study. HuH7 human hepatoma cells were infected with adenoviral particles containing genes coding GFP fused with wild-type Sar1 (Sar1 WT) or a GTPase mutant form (Sar1 H79G). When HuH7 cells were treated with oleic acid, Sar1 WT formed a ring-like structure around the LDs. The transient expression of Sar1 did not significantly alter the levels of TG and PLIN2 in the cells. However, the localization of PLIN2 to the LDs decreased in the cells expressing Sar1 H79G. Furthermore, the effects of Sar1 on PLIN2 localization to the LDs were verified by the suppression of endogenous Sar1 using the short hairpin RNA technique. In conclusion, it was found that Sar1 has some roles in the intracellular distribution of PLIN2 to LDs in liver cells.     

Uterine Deletion of Bmal1 Impairs Placental Vascularization and Induces Intrauterine Fetal Death in Mice

Recently, it was demonstrated that the expression of BMAL1 was decreased in the endometrium of women suffering from recurrent spontaneous abortion. To investigate the pathological roles of uterine clock genes during pregnancy, we produced conditional deletion of uterine Bmal1 (cKO) mice and found that cKO mice could receive embryo implantation but not sustain pregnancy. Gene ontology analysis of microarray suggested that uterine NK (uNK) cell function was suppressed in cKO mice. Histological examination revealed the poor formation of maternal vascular spaces in the placenta. In contrast to WT mice, uNK cells in the spongiotrophoblast layer, where maternal uNK cells are directly in contact with fetal trophoblast, hardly expressed an immunosuppressive NK marker, CD161, in cKO mice. By progesterone supplementation, pregnancy could be sustained until the end of pregnancy in some cKO mice. Although this treatment did not improve the structural abnormalities of the placenta, it recruited CD161-positive NK cells into the spongiotrophoblast layer in cKO mice. These findings indicate that the uterine clock system may be critical for pregnancy maintenance after embryo implantation.     

Tunable Terahertz Device Using Refractive Index Control

We measured the thermal dependencies of the refractive index and the absorption coefficient of high-resistivity silicon. We found that the refractive index varied slightly with temperature, and the absorption coefficient was very low and remained approximately constant as the temperature was changed. As a result, the conditions for terahertz propagation in silicon could be controlled by changing the refractive index without any absorption loss. As one application of this effect, we developed a terahertz time delay generator that can generate a terahertz time delay by changing the temperature of the medium through which the terahertz beam passes, without the need for any mechanical delay. We demonstrated generation of a terahertz time delay of approximately 6.6 ps.     

Denatured-jacalin derivatives with selective recognition for O-linked glycosides (ST,T, Tn,and STn Type) on IgA1 hinge region

Immunoglobulin A1 (IgA1) concentration in the plasma of patients with IgA nephropathy (IgAN) as the cause of renal failure is higher than that in the plasma of normal controls. IgA1 with abnormal sugars is considered to deposit in the glomerular mesangium, aggravating nephritis in IgAN. Jacalin is a lectin that recognizes sugars on IgA1. However, its selective-recognition for normal-type (ST type, NeuAc-α(2,3)-Gal-β(1,3)-GalNAc) and abnormal-type (T type, Gal-β(1,3)-GalNAc; Tn type, GalNAc; STn type, NeuAc-α(2,6)-GalNAc) sugars α-O-linked to serine/threonine in IgA1 is weak. Therefore, jacalin cannot be used for recognizing specific sugar types on IgA1. We attempted to develop a new recognition method for specific sugar types on IgA1 by utilizing the multirecognition capability of jacalin. Its binding abilities were regulated by heat denaturation with suitable template sugar (galactose or N-acetylgalactosamine). Further, we successfully prepared denatured-jacalin derivatives, which recognized ST-/T-type sugars on IgA1, by sugar-immobilized affinity chromatography. Enzyme-linked immunosorbent assay of denatured-jacalin derivatives, showed the ratios of abnormal sugars on IgA1 in the plasma of IgAN patients and normal controls to be approximately 60% and 20%, respectively. The results proved that profiling of sugar types in IgAN can successfully be performed by solely using jacalin derivatives.     

Recent Developments in Iron‐Making Technologies in Japan

The environment surrounding the iron and steel industry has changed greatly. This paper describes the technology adopted by the Japanese iron and steel industry to cope with changes in global demand, changes in the availability of coal and iron ore resources, correspondence to the extension of plant life, and energy conservation. In addition, efforts to reduce the amount of exhausted CO₂ due to environmental concerns are discussed.