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排序方式: 共有1363条查询结果,搜索用时 15 毫秒
31.
A Nakamura S Tanaka H Takayama M Sakamoto H Ishii M Kusano Y Onizuka S Ota K Mitamura 《Canadian Metallurgical Quarterly》1998,37(10):884-890
A 77-year-old female was admitted to our hospital because of pyrexia and a right retroperitoneal mass. Leukocytosis and other inflammatory findings were noted. Bone-marrow aspiration revealed hypercellularity with no malignant cells. An additional mass was detected sonographically in the pelvis. The serum concentration of granulocyte colony-stimulating factor (G-CSF) was highly elevated (299 pg/ml). The tumors were removed at laparotomy, and the pelvic mass was found to arise from the ileocecal mesentery. Postoperatively, white blood cell count and serum G-CSF concentrations decreased to normal levels. The mesenteric tumor showed weakly positive immunostaining for human G-CSF, and Northern and polymerase chain reaction (PCR) analyses detected CSF and its mRNA in the mesenteric tumor. 相似文献
32.
Dr. Daisuke Okuno Dr. Noriho Sakamoto Dr. Mohammed S. O. Tagod Yoshiko Akiyama Dr. Sakiko Moriyama Dr. Takuto Miyamura Dr. Atsuko Hara Dr. Takashi Kido Dr. Hiroshi Ishimoto Prof. Yuji Ishimatsu Prof. Takashi Tanaka Prof. Jun Ishihara Prof. Kohsuke Takeda Prof. Yoshimasa Tanaka Prof. Hiroshi Mukae 《ChemMedChem》2021,16(16):2515-2523
Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, is causally related to fibrotic diseases, including idiopathic pulmonary fibrosis. The identification of Compounds that interfere with the HSP47-collagen interaction is essential for the development of relevant therapeutics. Herein, we prepared human HSP47 as a soluble fusion protein expressed in E. coli and established an assay system for HSP47 inhibitor screening. We screened a natural and synthetic Compound library established at Nagasaki University. Among 1023 Compounds, 13 exhibited inhibitory activity against human HSP47, of which three inhibited its function in a dose-dependent manner. Epigallocatechin-3-O-gallate, one of these three Compounds, is a typical polyphenol Compound derived from tea leaves. Structurally related Compounds were synthesized and examined for their activity, revealing a hydroxyl group at A-ring position 5 as important for its activity. The present findings provide valuable insight for the development of natural product-derived therapeutics for fibrotic diseases, including idiopathic pulmonary fibrosis. 相似文献
33.
Masashi Ishikawa Masae Iwasaki Hailin Zhao Junichi Saito Cong Hu Qizhe Sun Atsuhiro Sakamoto Daqing Ma 《International journal of molecular sciences》2021,22(9)
Inhalational anesthetics was previously reported to suppress glioma cell malignancy but underlying mechanisms remain unclear. The present study aims to investigate the effects of sevoflurane and desflurane on glioma cell malignancy changes via microRNA (miRNA) modulation. The cultured H4 cells were exposed to 3.6% sevoflurane or 10.3% desflurane for 2 h. The miR-138, -210 and -335 expression were determined with qRT-PCR. Cell proliferation and migration were assessed with wound healing assay, Ki67 staining and cell count kit 8 (CCK8) assay with/without miR-138/-210/-335 inhibitor transfections. The miRNA downstream proteins, hypoxia inducible factor-1α (HIF-1α) and matrix metalloproteinase 9 (MMP9), were also determined with immunofluorescent staining. Sevoflurane and desflurane exposure to glioma cells inhibited their proliferation and migration. Sevoflurane exposure increased miR-210 expression whereas desflurane exposure upregulated both miR-138 and miR-335 expressions. The administration of inhibitor of miR-138, -210 or -335 inhibited the suppressing effects of sevoflurane or desflurane on cell proliferation and migration, in line with the HIF-1α and MMP9 expression changes. These data indicated that inhalational anesthetics, sevoflurane and desflurane, inhibited glioma cell malignancy via miRNAs upregulation and their downstream effectors, HIF-1α and MMP9, downregulation. The implication of the current study warrants further study. 相似文献
34.
Atsushi Fukuoka Yuzuru Sakamoto Takanori Higuchi Noriyuki Shimomura Masaru Ichikawa 《Journal of Porous Materials》2006,13(3-4):231-235
Platinum nanowires and nanoparticles were selectively synthesized in mesoporous silicas FSM-16 and HMM-1. The nanowires are 3 nm in diameter and several hundred nm to μm in length with high crystallinity. Pt nanowires and nanoparticles can be isolated by dissolving silica matrix with HF. The Pt wires extracted from organosilica HMM-1 have a nanonecklace structure, while the wires from siliceous FSM-16 have a nanorod structure. The extracted Pt nanoparticles (3 nm in size) on HOPG show the Coulomb staircase phenomena in STM/STS analysis. The mechanism for formation of the Pt nanowires is based on the migration of Pt ions in the mesoporous channels. 相似文献
35.
S. Watanabe T. Fujita M. Sakamoto H. Endo T. Kitazume 《Journal of the American Oil Chemists' Society》1987,64(6):874-875
Monofluoro esters were prepared by the reaction of hydroxy esters with N,N-diethyl-1,1,2,3,3,3-hexafluoro propylamine (PPDA).
Saponification of these monofluoroesters with enzyme (lipase MY) was attempted to give their corresponding monofluorocarboxylic
acids in moderate yields. 相似文献
36.
A supramolecular polymer formed by N,N′,N″-tris(3,7-dimethyloctyl)benzene-1,3,5-tricarboxamide (DO3B) in n-decane (C10) possesses large macro-dipoles naturally generated by three-fold inter-molecular hydrogen bonding aligned along its helical columnar structure connected by defective portions, which are DO3B molecules containing failure in the hydrogen bond formation, in the order of head to tail arrangement without dipole inversion like type-A polymers. 相似文献
37.
S. Watanabe T. Fujita M. Sakamoto T. Kuramochi H. Kawahara 《Journal of the American Oil Chemists' Society》1993,70(9):927-929
A number of N,N′-diacylalkyldiamines were prepared from the reaction of acid chlorides with 1,8-diaminooctane and 1,12-diaminododecane
and screened for anti-rust properties and antimicrobial activity in spent coolants of water-based cutting fluids. Aqueous
solutions of N,N′-dihexanoyl-1,8-diaminooctane and N,N′-isobutyroyl-1,12-diaminododecane showed good anti-rust properties
for water-based cutting fluids. Aqueous emulsions of N,N′-dibutyroyl-, dipentanoyl-, dihexanoyl- and dioctanoyl-1,12-diaminododecane
showed good lubricities and antimicrobial activity for water-based cutting fluids. 相似文献
38.
Toshinobu Yogo Wataru Sakamoto Tadayuki Isaji Koichi Kikuta Shin-ichi Hirano 《Journal of the American Ceramic Society》1997,80(7):1767-1772
Transparent and highly oriented Ba2 NaNb5 O15 (BNN) thin films have been prepared by using metal alkoxides. A homogeneous precursor solution was prepared by the controlled reaction of NaOC2 H5 , Nb(OC2 H5 )5 , and barium metal. The BNN precursor included a molecular-level mixture of NaNb(OC2 H5 )6 and Ba[Nb(OC2 H5 )6 ]2 in ethanol. The alkoxy-derived powder crystallized to a low-temperature phase, and then transformed to orthorhombic BNN (tungsten bronze) at 600°C. BNN precursor films on substrates crystallized to orthorhombic BNN at 800°C via the low-temperature phase. Highly (002) oriented BNN films of tungsten bronze structure were successfully prepared on MgO (100) substrates at 700°C by using BNN underlayer. 相似文献
39.
Takashi Kojima Wataru Sakamoto Toshinobu Yogo Takashi Fujii Shin-ichi Hirano 《Journal of the American Ceramic Society》2002,85(9):2212-2216
An in situ composite composed of ceria-stabilized tetragonal zirconia polycrystals (Ce-TZP) and La{Co0.5 Fe0.5 (Fe0.9 Al0.1 )11 }O19 was synthesized from a powder mixture of Ce-TZP, La(Fe0.9 Al0.1 )O3 , Fe2 O3 , Al2 O3 , and CoO. The dense Ce-TZP dispersed with platelike La{Co0.5 Fe0.5 (Fe0.9 Al0.1 )11 }O19 crystals as a second phase were formed after sintering from 1250° to 1350°C. The saturation magnetization of the in situ composite Ce-TZP/La{Co0.5 Fe0.5 (Fe0.9 Al0.1 )11 }O19 was proportional to the mass fraction of the hexaferrite second phase in Ce-TZP. The coercivity of the composite with a 20 mass% of second phase decreased from 9.14 to 2.52 kOe (from 728 to 201 kA/m) after the pulverization of the composite. The susceptibility (χ) increased by 15%–25% under uniaxial stress on the composite. The change of the susceptibility (Δχ/χ) value increased with decreasing the mass fraction of the second phase in the composite. The Δχ was found to increase linearly with applied stress and abruptly change on cracking, which is expected for the application in fracture sensing of the composite. 相似文献
40.
Yoshiyuki Sakamoto Tomoyoshi Motohiro Shinichi Matsunaga Kohei Okumura Tomoyuki Kayama Kiyoshi Yamazaki Toshiyuki Tanaka Yoshimi Kizaki Naoki Takahashi Hirofumi Shinjoh 《Catalysis Today》2007,121(3-4):217-225
The release and reduction of NOx in a NOx storage-reduction (NSR) catalyst were studied with a transient reaction analysis in the millisecond range, which was made possible by the combination of pulsed injection of gases and time resolved time-of-flight mass spectrometry. After an O2 pulse and a subsequent NO pulse were injected into a pellet of the Pt/Ba/Al2O3 catalyst, the time profiles of several gas products, NO, N2, NH3 and H2O, were obtained as a result of the release and reduction of NOx caused by H2 injection. Comparing the time profiles in another analysis, which were obtained using a model catalyst consisting of a flat 5 nmPt/Ba(NO3)2/cordierite plate, the release and reduction of NOx on Pt/Ba/Al2O3 catalyst that stored NOx took the following two steps; in the first step NO molecules were released from Ba and in the second step the released NO was reduced into N2 by H2 pulse injection. When this H2 pulse was injected in a large amount, NO was reduced to NH3 instead of N2.
A only small amount of H2O was detected because of the strong affinity for alumina support. We can analyze the NOx regeneration process to separate two steps of the NOx release and reduction by a detailed analysis of the time profiles using a two-step reaction model. From the result of the analysis, it is found that the rate constant for NOx release increased as temperature increase. 相似文献