Photochromic properties of polyimide and polysiloxane azopolymers

BACKROUND: One of the most important properties of the azobenzene chromophores is the photochemical trans–cis isomerization induced by UV or visible light. In azopolymers, the photoisomerization induces conformational changes in the polymer chains, which in turn lead to macroscopic variations in the chemical and physical properties of the surroundings and media. RESULTS: This work reports the photochromic behaviour and surface structuring capacity of azopolymers having rigid polyimide and flexible polysiloxane structures, respectively. These polymers have good thermostabilities, with the degradation process starting above 315 °C. The glass transition temperature of the azopolyimide is 228 °C, while that of the azopolysiloxane modified with thymine is 34 °C. CONCLUSION: The experiments show that the azobenzene groups can isomerize even in the case of the rigid polyimide, but the maximum degree of conversion to the cis isomer is less than in the case of the flexible polysiloxane. This behaviour is reversed in solution, probably due to both the thymine and azo group interactions and for conformational reasons. The azopolymers show a good surface structuring capacity. The polysiloxane is more sensitive in the case of low irradiation energy and irradiation time. By increasing the irradiation time for both polymers, the modulation depth increases and has comparable values. Copyright © 2008 Society of Chemical Industry     

Heuristics for the single source capacitated multi-facility Weber problem

The Single Source Capacitated Multi-facility Weber Problem (SSCMWP) is concerned with locating I capacitated facilities in the plane to satisfy the demand of J customers with the minimum total transportation cost of a single commodity such that each customer satisfies all its demand from exactly one facility. The SSCMWP is a non-convex optimization problem and difficult to solve. In the SSCMWP, customer locations, customer demands and facility capacities are known a priori. The transportation costs are proportional to the distance between customers and facilities. We consider both the Euclidean and rectilinear distance cases of the SSCMWP. We first present an Alternate Location and Allocation type heuristic and its extension by embedding a Very Large Scale Neighborhood search procedure. Then we apply a Discrete Approximation approach and propose both lower and upper bounding procedures for the SSCWMP using a Lagrangean Relaxation scheme. The proposed heuristics are compared with the solution approaches from the literature. According to extensive computational experiments on standard and randomly generated test sets, we can say that they yield promising performance.     

Water-Soluble Ruthenium(III)-Dimethyl Sulfoxide Complexes: Chemical Behaviour and Pharmaceutical Properties

In this paper we report a review of the results obtained in the last few years by our group in the development of ruthenium(III) complexes characterized by the presence of sulfoxide ligands and endowed with antitumor properties. In particular, we will focus on ruthenates of general formula Na[trans-RuCl(4)(R(1)R(2)SO)(L)], where R(1)R(2)SO = dimethylsulfoxide (DMSO) or tetramethylenesulfoxide (TMSO) and L = nitrogen donor ligand. The chemical behavior of these complexes has been studied by means of spectroscopic techniques both in slightly acidic distilled water and in phosphate buffered solution at physiological pH. The influence of biological reductants on the chemical behavior is also described. The antitumor properties have been investigated on a number of experimental tumors. Out of the effects observed, notheworthy appears the capability of the tested ruthenates to control the metastatic dissemination of solid metastasizing tumors. The analysis of the antimetastatic action, made in particular on the MCa mammary carcinoma of CBA mouse, has demonstrated a therapeutic value for these complexes which are able to significantly prolong the survival time of the treated animals. The antimetastatic effect is not attributable to a specific cytotoxicity for metastatic tumor cells although in vitro experiments on pBR322 double stranded DNA has shown that the test ruthenates bind to the macromolecule, causing breaks corresponding to almost all bases, except than thymine, and are able to cause interstrand bonds, depending on the nature of the complex being tested, some of which results active as cisplatin itself.     

Automatic determination of traffic accidents based on KMC-based attribute weighting

In this study, the traffic accidents recognizing risk factors related to the environmental (climatological) conditions that are associated with motor vehicles accidents on the Konya-Afyonkarahisar highway with the aid of Geographical Information Systems (GIS) have been determined using the combination of K-means clustering (KMC)-based attribute weighting (KMCAW) and classifier algorithms including artificial neural network (ANN) and adaptive network-based fuzzy inference system (ANFIS). The dynamic segmentation process in ArcGIS9.0 from the traffic accident reports recorded by District Traffic Agency has identified the locations of the motor vehicle accidents. The attributes obtained from this system are day, temperature, humidity, weather conditions, and month of occurred traffic accidents. The traffic accident dataset comprises five attributes (day, temperature, humidity, weather conditions, and month of occurred traffic accidents) and 358 observations including 179 without accident and 179 with accident. The proposed comprises two stages. In the first stage, the all attributes of dataset have been weighted using KMCAW method. The aims of this weighting method are both to increase the classification performance of used classifier algorithm and to transform from linearly non-separable traffic accidents dataset to a linearly separable dataset. In the second stage, after weighting process, ANN and ANFIS classifier algorithms have been separately used to determine the case of traffic accidents as with accident or without accident. In order to evaluate the performance of proposed method, the classification accuracy, sensitivity, specificity and area under the ROC (Receiver Operating Characteristic) curves (AUC) values have been used. While ANN and ANFIS classifiers obtained the overall prediction accuracies of 53.93 and 38.76%, respectively, the combination of KMCAW and ANN and the combination of KMCAW and ANFIS achieved the overall prediction accuracies of 74.15 and 55.06% on the prediction of traffic accidents. The experimental results have demonstrated that the proposed attribute weighting method called KMCAW is a robust and effective data pre-processing method in the prediction of traffic accidents on Konya-Afyonkarahisar highway in Turkey.     

Synthesis and study of new fluorinated poly(imide‐amide)s

New fluorinated poly(imide‐amide)s have been synthesized by solution polycondensation of various aromatic diamines containing a naphthalene unit with diacid chlorides having both imide and hexafluoroisopropylidene (6F) groups. These polymers are soluble in polar aprotic solvents, such as N‐methylpyrrolidone (NMP) or N,N‐dimethylformamide (DMF), and can be cast into flexible thin films from solutions. They show high thermooxidative stability with decomposition temperatures being above 425°C and glass transition temperatures being in the range of 235–305°C. The polymer films exhibit a low dielectric constant and tough mechanical properties.     

Compared properties of aromatic polyisophthalamides containing 5‐(4‐acetoxy‐benzamido) pendent groups

A series of aromatic polyamides containing 5‐(4‐acetoxy‐benzamido) pendent groups have been synthesized and their properties have been characterized and compared with those of related polyamides. The polyamides have weight‐ and number‐average molecular weights in the range of 36,680–65,700 and 12,685–35,490, respectively, and polydispersities in the range of 1.82–3.66. These polymers show good thermal stability comparable to traditional aromatic polyisophthalamides, with initial decomposition temperature between 270–320°C and glass transition temperature in the range of 230–270°C. Compared with related polyisophthalamides without any pendent groups, the present polymers show better solubility in certain solvents such as N‐methylpyrrolidinone and dimethylacetamide and can be cast from solutions into thin transparent flexible films having dielectric constants in the range of 3.42–4.27. The polymer films display remarkable hydrophilicity, which makes them potential candidates for use as advanced materials in humidity sensors. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 80: 650–657, 2001     

Gene Mutation Profiles in Primary Diffuse Large B Cell Lymphoma of Central Nervous System: Next Generation Sequencing Analyses

The existence of a potential primary central nervous system lymphoma-specific genomic signature that differs from the systemic form of diffuse large B cell lymphoma (DLBCL) has been suggested, but is still controversial. We investigated 19 patients with primary DLBCL of central nervous system (DLBCL CNS) using the TruSeq Amplicon Cancer Panel (TSACP) for 48 cancer-related genes. Next generation sequencing (NGS) analyses have revealed that over 80% of potentially protein-changing mutations were located in eight genes (CTNNB1, PIK3CA, PTEN, ATM, KRAS, PTPN11, TP53 and JAK3), pointing to the potential role of these genes in lymphomagenesis. TP53 was the only gene harboring mutations in all 19 patients. In addition, the presence of mutated TP53 and ATM genes correlated with a higher total number of mutations in other analyzed genes. Furthermore, the presence of mutated ATM correlated with poorer event-free survival (EFS) (p = 0.036). The presence of the mutated SMO gene correlated with earlier disease relapse (p = 0.023), inferior event-free survival (p = 0.011) and overall survival (OS) (p = 0.017), while mutations in the PTEN gene were associated with inferior OS (p = 0.048). Our findings suggest that the TP53 and ATM genes could be involved in the molecular pathophysiology of primary DLBCL CNS, whereas mutations in the PTEN and SMO genes could affect survival regardless of the initial treatment approach.     

A comparative analysis of several asymmetric traveling salesman problem formulations

In this survey, a classification of 24 asymmetric traveling salesman problem (ATSP) formulations is presented. The strength of their LP relaxations is discussed and known relationships from the literature are reviewed. Some new relationships are also introduced, and computational results are reported.     

Relationships between secondary dendrite arm spacing and mechanical properties of Zn-40Al-Cu alloys

Three ternary monotectoid-based Zn-40Al-(1, 2, 3%) Cu alloys were produced by permanent mould casting at different pouring and mould temperatures. The average cooling rate for each alloy was determined. Structure of the alloys was examined using optical and electron microscopes and their hardness, tensile strength, percentage elongation and impact energy were measured. As a result of these investigations the relationships between structure and mechanical properties of the alloys were determined.It was observed that the secondary dendrite arm spacing of the alloys decreased with increasing cooling rate and their hardness, tensile strength, percentage elongation and impact energy increased. Correlation of experimental results showed that the hardness, tensile strength, percentage elongation and impact energy of the alloys could be related to their secondary dendrite arm spacing using straight line equations.