Decreased Expression of Plakophilin-2 and αT-Catenin in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Markers for Diagnosis

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disease of the heart muscle. Clinical challenges remain, however, in identifying patients with ARVC in the early or concealed stages with subtle clinical manifestations. Therefore, we wanted to identify potential targets by immunohistochemical (IHC) analysis in comparison with controls. Pathogenic mutations were identified in 11 of 37 autopsied patients with ARVC. As observed from IHC analysis of the RV, expression of αT-catenin and plakophilin-2 is significantly decreased in autopsied patients with ARVC as compared to controls, and the decreased expression is consistent in patients with and without pathogenic mutations. Furthermore, ARVC specimens demonstrated a reduced localization of αT-catenin, desmocollin-2, desmoglein-2, desmoplakin, and plakophilin-2 on intercalated discs. These findings have been validated by comparing RV specimens obtained via endomyocardial biopsy between patients with ARVC and those without. The pathogenic mutation was present in 3 of 5 clinical patients with ARVC. In HL-1 myocytes, siRNA was used to knockdown CTNNA3, and western blotting analysis demonstrated that the decline in αT-catenin expression was accompanied by a significant decline in the expression of plakophilin-2. The aforementioned effect was directed towards protein degradation rather than mRNA stability. Plakophilin-2 expression decreases concurrently with the decline in CTNNA3 expression. Therefore, the expression of αT-catenin and plakophilin-2 could be potential surrogates for the diagnosis of ARVC.     

Editable Supercapacitors with Customizable Stretchability Based on Mechanically Strengthened Ultralong MnO2 Nanowire Composite

Although some progress has been made on stretchable supercapacitors, traditional stretchable supercapacitors fabricated by predesigning structured electrodes for device assembling still lack the device‐level editability and programmability. To adapt to wearable electronics with arbitrary configurations, it is highly desirable to develop editable supercapacitors that can be directly transferred into desirable shapes and stretchability. In this work, editable supercapacitors for customizable shapes and stretchability using electrodes based on mechanically strengthened ultralong MnO₂ nanowire composites are developed. A supercapacitor edited with honeycomb‐like structure shows a specific capacitance of 227.2 mF cm^?2 and can be stretched up to 500% without degradation of electrochemical performance, which is superior to most of the state‐of‐the‐art stretchable supercapacitors. In addition, it maintains nearly 98% of the initial capacitance after 10 000 stretch‐and‐release cycles under 400% tensile strain. As a representative of concept for system integration, the editable supercapacitors are integrated with a strain sensor, and the system exhibits a stable sensing performance even under arm swing. Being highly stretchable, easily programmable, as well as connectable in series and parallel, an editable supercapacitor with customizable stretchability is promising to produce stylish energy storage devices to power various portable, stretchable, and wearable devices.     

清洁生产在环境影响评价中的应用

本文重点针对清洁生产在环境影响评价中的应用进行了详细的分析,以供参考.     

星环形计算机局域网的性能研究

本文结合星形(Star)和环形(Ring)拓扑结构,提出了一种全新的LAN(Local Area Network)结构——星环形LAN.它以较低廉的代价在网络的几个主要性能指标上获得较大的提高.本文论述了星环形LAN(StarRing LAN)的设计思想和各性能指标的研究结果.     

基于JMS异步消息的心跳监听设计与实现

阐述了如何利用Java消息服务和心跳技术实现对分散模块状态的监控，以及保证模块间通信无阻。通过收发消息的形式，集中监控关键模块，并准确定位故障所在，尽可能保证系统长时间的无故障运作。     

基于特征映射的互联网频繁模式识别算法

提出了一种基于特征映射的互联网频繁模式识别算法,采用特征映射与聚类相结合的方法,解决了SPADE算法不能反映类信息的问题与大量数据聚类时的效率低下,同时,提出了比较合理的频繁模式定量评价体系,从而完成了识别系统的整体设计,对于处理互联网海量用户数据有着相当重要的作用,同时,可以根据此算法提供个性化推荐等服务来提升用户体验.     

Biophotonic probes for bio-detection and imaging

The rapid development of biophotonics and biomedical sciences makes a high demand on photonic structures to be interfaced with biological systems that are capab...     

PDA用于注射液中微粒检测的研究

本文以激光相位多普勒（ＰＤＡ）技术为基础,利用ＰＤＡ信号探测器及高速信号的处理系统,实现了注射液中不溶性微粒的尺寸分布检测,对ＰＤＡ技术的实用化研究进行了有益的探索。