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11.
Hideki Shige Toshitsugu Ishikawa Michio Suzukawa Masato Nishiwaki Takeshi Yamashita Kei Nakajima Toshimitsu Ito Kenji Higashi Makoto Ayaori Atsushi Yonemura Paul Nestel Haruo Nakamura 《Lipids》1998,33(12):1169-1175
The effects of vitamin E on cholesteryl ester (CE) metabolism in 1774 cells were examined. Pretreatment of 1774 cells with
vitamin E at concentrations above 50 μM significantly decreased acetylated low density lipoprotein (LDL)-induced incorporation
of [14C]oleate into CF in cells in a dose-dependent manner. This was partly due to vitamin E Also significantly inhibiting the uptake
of [3H]CE-labeled acetylated LDL by 1774 cells. A trend existed toward suppression of acyl-CoA:cholesterol acyltransferase (ACAT)
activity in the cell lysate at high vitamin E concentration, but there was no effect on hydrolysis of CE. These data indicate
that vitamin E reduces the uptake of modified LDL and suppresses ACAT activity, resulting in less cholesterol esterification
in macrophages; a novel mechanism underlying the antiatherogenic properties of vitamin E. 相似文献
12.
Motoyuki Ozaki Toshimitsu Higashi Taiki Ogata Tatsunori Hara Jose Ildefonso Udang Rubrico 《Advanced Robotics》2016,30(22):1446-1457
Distribution centers, which are essential to our society, are becoming increasingly important. Although the efficiency of an AVS/RS (Autonomous vehicle storage and retrieval system) makes it a promising system, there is still much to be studied regarding its effective use and design. This paper proposes a method of designing AVS/RSs through a quantitative consideration of group constraint by utilizing probability theory. The proposed algorithm also deals with the problem of designing the sizes of several buffers, and considers the effect of load fluctuations, which are important for real-world operation, by use of queuing network theory. Effectiveness of the proposed algorithm is shown with simulations of various number of groups, those of various safety factors for fluctuations, and those of various evasion rates for buffer overflow. The design results are shown to be much different from those which do not consider those factors. The results prove that the proposed method provides an accurate quantitative assessment of the AVS/RS’s constraints. 相似文献
13.
In this paper, we study nonblocking decentralized supervisory control of discrete event systems. We introduce a modified normality condition defined in terms of a modified natural projection map. The modified normality condition is weaker than the original one and stronger than the co-observability condition. Moreover, it is preserved under union. Given a marked language specification, there exists a nonblocking decentralized supervisor for the supremal sublanguage which satisfies Lm(G)-closure, controllability, and modified normality. Such a decentralized supervisor is more permissive than the one which achieves the supremal Lm(G)-closed, controllable, and normal sublanguage. 相似文献
14.
Takayuki Kumada Shoji Mori Toshimitsu Nagasaka Jun Kumagai Tetsuo Miyazaki 《Journal of Low Temperature Physics》2001,122(3-4):265-277
The tunneling abstraction reaction: H+H2H2+H in -irradiated solid hydrogen has been studied using electron spin resonance (ESR) and electron-nuclear double resonance (ENDOR) spectroscopy and gas-chromatography. The rate constant for the tunneling reaction in solid hydrogen was found to decrease with the increase in the concentration of ortho-H2 molecules in solid hydrogen. We concluded that the decrease in the rate constant is due to the energy level mismatching between reactant species of H+H2 trapped and product species of H2+H trapped in the reverse induced by inhomogeneous intermolecular interactions between ortho-H2 molecules in solid hydrogen. This result indicates that resonance effects play an important role in tunneling reactions in solids. 相似文献
15.
Makoto Nikaido Toyokazu Kobayashi Tomio Ito Toshimitsu Higashi Hirofumi Tamura 《Advanced Robotics》2013,27(11-12):1229-1252
An analytic flow design algorithm for an automated distribution center with multiple shipping areas is presented. The main elements of the analytic flow design are the number of devices and the volumes of product flow between the devices. In the design of an automated distribution center, it is necessary to satisfy the demand throughput while minimizing construction costs. In the conventional design process, system engineers utilize experimental and intuitional approaches. However, conventional approaches are time-consuming and the design outcome is dependent on the skill of the designer. Therefore, a theoretical design algorithm is needed. We propose an analytic flow design algorithm using a dynamic network flow model and considering time-variable flow volumes according to shipment and storage schedules. To verify the feasibility of the proposed method, we perform analytic flow design using real data and confirm that the proposed method can yield a feasible analytic flow design in several minutes. 相似文献
16.
The effects of infusion of trieicosapentaenoyl-glycerol emulsion on extravascular lung water during myocardial ischemia and reperfusion in dogs 总被引:2,自引:0,他引:2
Toshio Izuoka Yutaka Kimura Tomohito Hamazaki Teruhiro Tamura Shuji Kitashiro Tetsuro Sugiura Toshimitsu Jikuhara Toshiji Iwasaka 《Lipids》1997,32(1):109-114
To test the effects of eicosapentaenoic acid (EPA) infusion on pulmonary edema induced by coronary ligation and reperfusion,
extravascular lung water (EVLW) was measured in situ by the thermal-dye double indicator dilution method in dogs. In the control group of five dogs, 30 mL of a 10% soybean oil
emulsion was infused through a leg vein. One hour after infusion, the left anterior descending coronary artery below the first
diagonal branch was ligated for 15 min and then reperfused for 30 min. In the EPA group, six dogs were similarly treated with
an emulsion of a 10% trieicosapentaenoyl-glycerol (90% pure). EVLW, pulmonary capillary wedge pressure, mean pulmonary artery
pressure, mean blood pressure, and cardiac index were measured before and 15 min after coronary ligation, and 15 min and 30
min after coronary reperfusion. There were no significant differences in the hemodynamic indices between the two groups. EVLW
significantly increased up to two times of baseline during coronary ligation in the control group (P< 0.05) and more during reperfusion (P<0.01), whereas EVLW did not increase in the EPA group. In conclusion, EPA inhibited EVLW accumulation and may be useful for
ameliorating one of the ischemia-reperfusion-induced complications, pulmonary edema. 相似文献
17.
Tauer A Bender TO Fleischmann EH Niwa T Jörres A Pischetsrieder M 《Molecular nutrition & food research》2005,49(7):710-715
Conventional fluids for peritoneal dialysis (PD) contain reactive glucose degradation products (GDPs) as a result of glucose breakdown during heat-sterilization. GDPs in PD fluids (PDFs) have been associated with the progressive alteration of the peritoneal membrane during long-term PD by cytotoxic effects and formation of advanced glycation endproducts (AGEs). In this study, we investigated the possible fate of two characteristic GDPs, 3-deoxyglucosone (3-DG) and glyoxal, during PD. In vivo, 3-DG and glyoxal concentrations, which were analyzed by high-performance liquid chromatography (HPLC), decreased in PDFs by 78% and 88% during 4 h of dwell time. The PDFs were then incubated in vitro in the presence of the most important reaction partners of GDPs in the peritoneal cavity. Neither human peritoneal mesothelial cells, human peritoneal fibroblasts, soluble protein, an insoluble collagen surface, nor components of spent dialysate led to a significant reduction of 3-DG or glyoxal after 6 h. Only after long-term incubation, a noticeable decrease of 3-DG was observed (-37% after three weeks), more likely due to spontaneous degradation reaction than formation of advanced glycation endproducts. These results suggest that in the course of PD, 3-DG, and glyoxal are absorbed into the organism and thus might contribute to the systemic pool of reactive carbonyl compounds. 相似文献
18.
Acrolein formation in the oxidation of ethane over silica catalysts supporting iron and cesium 总被引:1,自引:0,他引:1
Kiyoharu Nakagawa Yonghong Teng Zhen Zhao Yusuke Yamada Atsushi Ueda Toshimitsu Suzuki Tetsuhiko Kobayashi 《Catalysis Letters》1999,63(1-2):79-82
A significant yield of aldehydes was obtained by the partial oxidation of ethane over alkali‐modified Fe/SiO2 catalysts at 475°C (<2% in the case of Cs–Fe/SiO2). Not only acetaldehyde and formaldehyde but also acrolein were produced in the present system. There are no reports regarding
the catalysts for the direct acrolein formation from partial oxidation of ethane. Such significant promoting effect of alkali‐modified
Fe/SiO2 catalysts in the partial oxidation of hydrocarbons has never been observed. Aldol‐type condensation for formation of acrolein
could occur in the partial oxidation of ethane over alkali‐modified Fe/SiO2 catalysts.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
19.
The reduction of 1,1,4,4-tetrakis[bis(trimethylsilyl)methyl]-1,4-diisopropyltetrasila-2-yne 1 with an equivalent amount of alkali metal (Li, Na, K, KC8) in THF produced the corresponding disilyne anion radicals 2a–c. Their EPR spectra are independent of the metals used in THF, indicating that the disilyne anion radical species exists as solvent-separated ion pairs in polar solvents. The one-electron reduction also occurred with potassium in toluene to produce the potassium salt of the anion radical 3, which was isolated as extremely air- and moisture-sensitive dark brown crystals. The molecular structure of 3 was established by X-ray crystallography, which showed that the potassium ion is solvated by one toluene molecule. The EPR spectrum of 3 in toluene showed the interaction of the anionic silicon atom with the K+ ion. 相似文献
20.