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排序方式: 共有416条查询结果,搜索用时 17 毫秒
321.
We report noninvasive monitoring of the transporter-substrate interaction at the cell membrane using an oocyte-based field effect transistor (FET), which is based on detection of extracellular potential change induced as a result of the interaction between transporting peptide and substrate at the cell membrane. The interface potential change at the cell membrane/gate insulator interface can be monitored during the uptake of substrate mediated by transporter without any labeling materials and fracturing oocyte. Moreover, we can discriminate the transporting kinetics of the substrate mediated by the wild-type and the mutant-type transporters by use of the oocyte-based FETs. Our findings on the time course of the interface potential would provide important information to understand the molecular mechanism of the uptake kinetics for the OATP-C transporter. 相似文献
322.
Tanabe Y Yasuda K Azuma C Taniguro H Onodera S Suzuki A Chen YM Gong JP Osada Y 《Journal of materials science. Materials in medicine》2008,19(3):1379-1387
The study evaluated biological reaction of four types of novel double network gels in muscle and subcutaneous tissues, using
implantation tests according to the international guideline. The implantation tests demonstrated that, although poly (2-acrylamide-2-metyl-propane
sulfonic acid)/poly (N,N′-dimetyl acrylamide) (PAMPS/PDMAAm) gel induced a mild inflammation at 1 week, the degree of the inflammation significantly
decreased into the same degree as that of the negative control at 4 and 6 weeks. This gel has a potential to be applied as
artificial cartilage. In addition, Cellulose/Gelatin gel showed the same degree of inflammation as that of the negative control
at 1 week, and then, showed a gradually absorbable property at 4 and 6 weeks. This gel has a potential to be applied as an
absorbable implant. The PAMPS/polyacrylamide and Cellulose/PDMAAm gels induced a significant inflammation at each week. These
DN gels are difficult to be applied as clinical implants in the current situation. 相似文献
323.
Shingo Ozaki Kazuki Yamagata Chihiro Ito Takuma Kohata Toshio Osada 《Journal of the American Ceramic Society》2022,105(3):2182-2195
The estimation of the strength scatter caused by internal defects is necessary in analyzing a reliable design of advanced ceramic components. In this study, we proposed a finite element analysis methodology to predict the stochastic fracture behavior of ceramics based on the microstructural features obtained by the scanning electron microscopy and X-ray computed tomography. Here, the two- and three-dimensional distribution microstructural data are approximated by various probability density functions and are reflected in the dispersion of parameters of the damage model via a fracture mechanics model. We then applied the proposed method to alumina fine ceramics sintered at three different temperatures, and performed the three-point bending test. Furthermore, the numerically created Weibull distributions were compared with those obtained experimentally. Our analysis results confirm that the proposed method can reasonably predict the strength scatter in ceramics. 相似文献
324.
Kwon HJ Shikinaka K Kakugo A Furukawa H Osada Y Gong JP 《Journal of nanoscience and nanotechnology》2007,7(3):844-847
We report a soft gel machine reconstructed from muscle proteins. We have found that chemically cross-linked polymer-actin complex gel can move on myosin coated surface with a velocity as high as that of native F-actin, by coupling to ATP hydrolysis. Additionally, it is shown that the velocity and motional pattern of polymer-actin complex gel depends on the morphology of polymer-complex gels. Since the designing of functional actuator into well-defined size and morphology is important, the structural behavior of polymer-actin complexes has been investigated. This result shows that the morphology and growth size of polymer-actin complex can be controlled by change of electrostatic interaction between F-actins and polycations. Our results indicate that bio actuator with desired shape can be created by using polymer-actin complex. 相似文献
325.
Tomita Y Ikeda M Mutoh H Inada T Iwata N Ozaki N Honda H 《Journal of Bioscience and Bioengineering》2007,103(4):303-310
Several single marker association and haplotypic analyses have been performed to identify susceptible genes for various common diseases, but these approaches using candidate genes did not provide accurate and consistent evidence in each analysis. This inconsistency is partly due to the fact that the common diseases are caused by complex interactions among various genetic factors. Therefore, in this study, to evaluate exhaustive genotype or allele combinations, we applied the binomial and random permutation test (BRP) proposed by Tomita et al. [IPSJ Digital Courier, 2, 691-709 (2006)] for the association analysis between an Apolipoprotein L gene cluster and schizophrenia. Using the seven selected representative single nucleotide polymorphisms (SNPs) based on the results of linkage disequilibrium evaluation, we analyzed 845 schizophrenic patients and 707 healthy controls, and investigated the validation of risk and protective factors with two randomly divided data sets. A comparative study of a method for analyzing the interactions was performed by conventional methods. Even if all the tested methods were used for analysis, the risk factor with a high significance was not commonly selected from both independent data sets. However, the significant interactions for the protective factor against disease development were commonly obtained from both data sets by BRP analysis. In conclusion, although it is considered that the causality of schizophrenia is too complex to identify a susceptible interaction using a small sample size, it was suggested that the healthy controls tend to have the same combination of certain alleles or genotypes for protection from disease development when BRP as a new exhaustive combination analytical method was used. 相似文献
326.
White-light-emitting materials have attracted considerable attention because of their applications, such as large-surface emitting devices. Inorganic phosphor films are expected to be applied to these devices because of good chemical stability; however, a substantial reduction of fabrication temperature is required for future industrial uses such as lighting materials fabricated onto flexible organic substrates. Here we show the optical properties of white-light-emitting metavanadate phosphors, AVO3 (A: K, Rb and Cs), and we report a new direct fabrication process for RbVO3 films onto flexible polyethylene terephthalate (PET) substrates by means of a vacuum ultraviolet irradiation using an excimer lamp. In addition, the (Ca,Sr,Pr)TiO3/a-Al2O3/RbVO3/PET heterostructure prepared by an excimer-laser-assisted metal-organic deposition process has demonstrated the possibility of colour modification for RbVO3 films on PET. Our findings suggest new possibilities for further development of large-surface emitting lighting devices. 相似文献
327.
Synthesis and Chemical Characterization of Hydrocarbons with a 6,9,11-, 3,6,9,11-, or 1,3,6,9-Polyene System,Pheromone Candidates in Lepidoptera 总被引:1,自引:1,他引:0
Yamamoto M Yamakawa R Oga T Takei Y Kinjo M Ando T 《Journal of chemical ecology》2008,34(8):1057-1064
Lepidopteran Type II sex pheromones are mainly composed of 6,9-dienes, 3,6,9-trienes, and their epoxy derivatives, which are biosynthesized from linoleic and linolenic acids by the species in some families of higher Lepidoptera. To investigate further structural modifications on this theme, we synthesized polyunsaturated hydrocarbons with a C(17)-C(21) chain, which included an extra double bond. Using the Wittig reaction, (Z,Z,E)-6,9,11-trienes and (Z,Z,Z,E)-3,6,9,11-tetraenes were synthesized from (E)-2-alkenals with appropriate carbon chains, and (Z,Z,Z)-1,3,6,9-tetraenes were synthesized from 3-hexyn-1,6-diol. The gas chromatography-mass spectrometry (GC-MS) analysis of each synthetic polyene, whose chemical structure was confirmed by (1)H NMR and (13)C NMR, revealed some characteristic fragment ions reflecting the positions of the double bonds, i.e., m/z 79, 110, 163, and M-85 of the 6,9,11-trienes, m/z 79, 108, and M-82 of the 3,6,9,11-tetraenes, and m/z 79, 91, 106, and M-54 of the 1,3,6,9-tetraenes. Because the determination of the unsaturated positions is difficult to accomplish by chemical derivatization with a limited amount of natural pheromones, these diagnostic ions found in authentic samples would help identify the hydrocarbons in a pheromone extract. Furthermore, we carried out field screening tests of these polyenes in forests in Japan, and documented the attraction of four geometrid species in Tokyo and one noctuid species in the Iriomote Islands. 相似文献
328.
Rachid Belkada Toshiya Shibayanagi Masaaki Naka Masanori Kohyama 《Journal of the American Ceramic Society》2000,83(10):2449-2454
The atomic and electronic structure of the β-silicon nitride (β-Si3 N4 ) crystal have been determined using the ab initio pseudopotential method based on the density functional theory. We have obtained the stable lattice parameters and the stable positions of 14 atoms in the unit cell for the structure P 63 / m for the first time. The electronic structure and the charge distribution indicate that the Si–N bond has both ionic and covalent characters. The band structure is in good agreement with the other first-principles results and consistent with the experiments. 相似文献
329.