The selective wetting behavior of silica in emulsion styrene butadiene rubber (ESBR)/solution styrene butadiene rubber (SSBR) blends is characterized by the wetting concept, which is further developed for filled blends based on miscible rubbers. It is found that not only the chemical rubber–filler affinity but also the topology of the filler surface significantly influences the selective filler wetting in rubber blends. The nanopore structure of the silica surface has been recognized as the main reason for the difference in the wetting behavior of the branched ESBR molecules and linear SSBR molecules. However, the effect of nanopore structure becomes more significant in the presence of silane. It is discussed that the adsorption of silane on silica surface constricts the nanopore to some extent that hinders effectively the space filling of the nanopores by the branched ESBR molecules but not by the linear SSBR molecules. As a result, in silanized ESBR/SSBR blends the dominant wetting of silica surface by the tightly bonded layer of SSBR molecules causes a low‐energy dissipation in the rubber–filler interphase. That imparts the low rolling resistance to the blends similar to that of a silica‐filled SSBR compound, while the ESBR‐rich matrix warrants the good tensile behavior, i.e., good abrasion and wear resistance of the blends.
I. Introduction Streaming media has been widely used over the Internet in recent years. However, the growing use in streaming media, which generally has large size, can have a significant impact on the user perceived latency and network congestion. A popular approach to reduce the response time and backbone bandwidth consumption is to deploy proxy caches at the edge of the Internet. Due to the large size and different popularity for different part of the streaming video, it is not practical … 相似文献
Intervertebral disc (IVD) diseases are common spinal disorders that cause neck or back pain in the presence or absence of an underlying neurological disorder. IVD diseases develop on the basis of degeneration, and there are no established treatments for degeneration. IVD diseases may therefore represent a candidate for the application of regenerative medicine, potentially employing normal human dermal fibroblasts (NHDFs) induced to differentiate into nucleus pulposus (NP) cells. Here, we used a three-dimensional culture system to demonstrate that ectopic expression of MYC, KLF4, NOTO, SOX5, SOX6, and SOX9 in NHDFs generated NP-like cells, detected using Safranin-O staining. Quantitative PCR, microarray analysis, and fluorescence-activated cell sorting revealed that the induced NP cells exhibited a fully differentiated phenotype. These findings may significantly contribute to the development of effective strategies for treating IVD diseases. 相似文献
Microglial interaction with amyloid fibrils in the brains of Alzheimer's and prion disease patients results in the inflammatory activation of these cells. We observed that primary microglial cultures and the THP-1 monocytic cell line are stimulated by fibrillar beta-amyloid and prion peptides to activate identical tyrosine kinase-dependent inflammatory signal transduction cascades. The tyrosine kinases Lyn and Syk are activated by the fibrillar peptides and initiate a signaling cascade resulting in a transient release of intracellular calcium that results in the activation of classical PKC and the recently described calcium-sensitive tyrosine kinase PYK2. Activation of the MAP kinases ERK1 and ERK2 follows as a subsequent downstream signaling event. We demonstrate that PYK2 is positioned downstream of Lyn, Syk, and PKC. PKC is a necessary intermediate required for ERK activation. Importantly, the signaling response elicited by beta-amyloid and prion fibrils leads to the production of neurotoxic products. We have demonstrated in a tissue culture model that conditioned media from beta-amyloid- and prion-stimulated microglia or from THP-1 monocytes are neurotoxic to mouse cortical neurons. This toxicity can be ameliorated by treating THP-1 cells with specific enzyme inhibitors that target various components of the signal transduction pathway linked to the inflammatory responses. 相似文献
The breakdown phenomena in SiO/sub x/N/sub y/ (EOT=20 /spl Aring/) gate dielectric under a two- stage constant voltage stress in inversion mode are physically analyzed with the aid of transmission electron microscopy. The results show that dielectric-breakdown-induced epitaxy (DBIE) remains as one of the major failure defects responsible for gate dielectric breakdown evolution even for a stress voltage as low as 2.5 V. Based on the results, the same failure mechanism i.e., presence of DBIE would be responsible for the degradation in ultrathin gate dielectrics for gate voltage below 2.5 V. It is believed that DBIE will be present in MOSFETs failed at nominal operating voltage. 相似文献
Concrete beams retrofitted with bonded fiber reinforced plastic (FRP) plates often fail by debonding of the plate from the concrete surface. To predict the failure load in design, a proper debonding model is required. As debonding is a nonlinear process involving material softening, it can be analyzed once the interfacial shear (τ) versus sliding (s) relationship is known. Recent experimental results indicate that the simplest τ-s relationship should involve three parameters: the maximum shear stress for debonding to initiate, the initial residual stress right after debonding occurs, and a parameter governing the reduction of shear stress with sliding. In this paper, a FRP debonding model based on these three parameters is developed. The applicability of the model is verified through comparison with experimental results. Through a systematic parametric study, the effect of various material and geometric properties on the debonding process is investigated. Implications to the design of FRP strengthened members are highlighted. 相似文献
The electro-elastic characteristics of clamped rectangular piezoelectric laminated plates were analytically investigated. A fully covered electrode piezoelectric layer was laminated on an elastic layer to form a nonsymmetrical laminated plate. Using the electro-elastic theory with the Kirchhoff-Love hypothesis, formulation of analyses for mechanical, electrical, and electromechanical characteristics of the laminae are presented. Numerical analysis was carried out using the extended Kantorovich method to yield eigenvalues and eigenfunctions. Theoretical predictions of dynamic characteristics were validated by comparing results with finite element analysis data. The calculated natural frequencies are presented in easy-to-use figures that are useful for sensor and actuator design in microelectromechanical systems (MEMS). 相似文献