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881.
H. H. Kendler (see record 1994-09190-001), in his article on psychology and the ethics of social policy, argues in part that ethical imperatives cannot be inferred from empirical data. This argument is cited in opposition to what is purported to be the position of the American Psychological Association on the abortion issue. It is suggested that PhD candidates in psychology be well versed in the philosophical issues and debates that are the foundation for the formation of ethical principles. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
882.
G Scala I Quinto MR Ruocco M Mallardo C Ambrosino B Squitieri P Tassone S Venuta 《Canadian Metallurgical Quarterly》1993,67(5):2853-2861
Human immunodeficiency virus type 1 (HIV-1)-infected subjects show a high incidence of Epstein-Barr virus (EBV) infection. This suggests that EBV may function as a cofactor that affects HIV-1 activation and may play a major role in the progression of AIDS. To test this hypothesis, we generated two EBV-negative human B-cell lines that stably express the EBNA2 gene of EBV. These EBNA2-positive cell lines were transiently transfected with plasmids that carry either the wild type or deletion mutants of the HIV-1 long terminal repeat (LTR) fused to the chloramphenicol acetyltransferase (CAT) gene. There was a consistently higher HIV-1 LTR activation in EBNA2-expressing cells than in control cells, which suggested that EBNA2 proteins could activate the HIV-1 promoter, possibly by inducing nuclear factors binding to HIV-1 cis-regulatory sequences. To test this possibility, we used CAT-based plasmids carrying deletions of the NF-kappa B (pNFA-CAT), Sp1 (pSpA-CAT), or TAR (pTAR-CAT) region of the HIV-1 LTR and retardation assays in which nuclear proteins from EBNA2-expressing cells were challenged with oligonucleotides encompassing the NF-kappa B or Sp1 region of the HIV-1 LTR. We found that both the NF-kappa B and the Sp1 sites of the HIV-1 LTR are necessary for EBNA2 transactivation and that increased expression resulted from the induction of NF-kappa B-like factors. Moreover, experiments with the TAR-deleted pTAR-CAT and with the tat-expressing pAR-TAT plasmids indicated that endogenous Tat-like proteins could participate in EBNA2-mediated activation of the HIV-1 LTR and that EBNA2 proteins can synergize with the viral tat transactivator. Transfection experiments with plasmids expressing the EBNA1, EBNA3, and EBNALP genes did not cause a significant HIV-1 LTR activation. Thus, it appears that among the latent EBV genes tested, EBNA2 was the only EBV gene active on the HIV-1 LTR. The transactivation function of EBNA2 was also observed in the HeLa epithelial cell line, which suggests that EBV and HIV-1 infection of non-B cells may result in HIV-1 promoter activation. Therefore, a specific gene product of EBV, EBNA2, can transactivate HIV-1 and possibly contribute to the clinical progression of AIDS. 相似文献
883.
JL Boyer S Siddiqi B Fischer T Romero-Avila KA Jacobson TK Harden 《Canadian Metallurgical Quarterly》1996,118(8):1959-1964
1. A series of chain-extended 2-thioether derivatives of adenosine monophosphate were synthesized and tested as agonists for activation of the phospholipase C-linked P2Y-purinoceptor of turkey erythrocyte membranes, the adenylyl cyclase-linked P2Y-purinoceptor of C6 rat glioma cells, and the cloned human P2U-receptor stably expressed in 1321N1 human astrocytoma cells. 2. Although adenosine monophosphate itself was not an agonist in the two P2Y-purinoceptor test systems, eleven different 2-thioether-substituted adenosine monophosphate analogues were full agonists. The most potent of these agonists, 2-hexylthio AMP, exhibited an EC50 value of 0.2 nM for activation of the C6 cell receptor. This potency was 16,000 fold greater than that of ATP and was only 10 fold less than the potency of 2-hexylthio ATP in the same system. 2-hexylthio adenosine was inactive. 3. Monophosphate analogues that were the most potent activators of the C6 cell P2Y-purinoceptor were also the most potent activators of the turkey erythrocyte P2Y-purinoceptor. However, agonists were in general more potent at the C6 cell receptor, and potency differences varied between 10 fold and 300 fold between the two receptors. 4. Although 2-thioether derivatives of adenosine monophosphate were potent P2Y-purinoceptor agonists no effect of these analogues on the human P2U-purinoceptor were observed. 5. These results support the view that a single monophosphate is sufficient and necessary for full agonist activity at P2Y-purinoceptors, and provide insight for strategies for development of novel P2Y-purinoceptor agonists of high potency and selectivity. 相似文献
884.
Manivannan D. Netzer R.H.B. Singhal M. 《Parallel and Distributed Systems, IEEE Transactions on》1997,8(6):623-627
Consistent global checkpoints have many uses in distributed computations. A central question in applications that use consistent global checkpoints is to determine whether a consistent global checkpoint that includes a given set of local checkpoints can exist. Netzer and Xu (1995) presented the necessary and sufficient conditions under which such a consistent global checkpoint can exist, but they did not explore what checkpoints could be constructed. In this paper, we prove exactly which local checkpoints can be used for constructing such consistent global checkpoints. We illustrate the use of our results with a simple and elegant algorithm to enumerate all such consistent global checkpoints 相似文献
885.
In a previous study a solvent mixture of heptane containing 40 mass % heptanol was selected as an alternative in the industrial extraction of caprolactam to replace benzene, toluene, or chlorinated hydrocarbons. This work reports the equilibrium distribution ratio of caprolactam and four model impurities of organic nature, namely, cyclohexanone, aniline, n‐methylcaprolactam, and cyclohexane‐carboxamide, comparing the mixed solvents with toluene as a reference. The resulting phase equilibria were interpreted using the equilibrium stage model. Based on these calculations it was found that, compared to toluene, the co‐extracted fraction of cyclohexanone and aniline was higher, that of n‐methylcaprolactam was comparable, and that of cyclohexane‐carboxamide was lower using the mixed solvent. Overall, the mixed solvent reduced the fraction of co‐extracted impurities by almost 10 %. 相似文献
886.
We have developed composite layered temperature-resistant silicon-organic sandwich-type coatings with thin polyurethane silicon-organic
interlayers. We used the following materials as binding components: KO 921 silicon-organic lacquer with addition of éD-20
epoxy resin for prime coat, the same lacquer with addition of PZ 1040 S polyurethane elastomer for thin soft interlayers,
and only KO 921 lacquer for thick hard layers. The mineral filler represented a mixture of coal ash and omiacarb in proportion
70 / 30 mass %. We have manufactured and tested laboratory specimens with two hard layers and two interlayers as well as with
three hard layers and two thin interlayers. We have established that the developed composite layered coatings exceed, in their
basic characteristics, the requirements of the State Standard Committee of Ukraine and foreign normative documents for the
rust protection of steel main pipelines. Our coatings possess high impact strength, heightened elasticity and adhesion strength
and, as to their electrical insulating characteristics, exceed these requirements by an order of magnitude. We note the complexity
of the technology of applying layered composite coatings and the necessity of its improvement.
__________
Translated from Fizyko-Khimichna Mekhanika Materialiv, Vol. 42, No. 4, pp. 59–65, July–August, 2006. 相似文献
887.
Haas R. Kencl L. Kind A. Metzler B. Pletka R. Waldvogel M. Frelechoux L. Droz P. Jeffries C. 《IEEE network》2003,17(4):46-54
In this article we present five case studies of advanced networking functions that detail how a network processor (NP) can provide high performance and also the necessary flexibility compared with ASIC. We first review the basic NP system architectures, and describe the IBM PowerNP architecture from the data plane as well as the control plane point of view. We introduce models for the programmer's views of NP that facilitate a global understanding of NP software programming. Then, for each case study, we present results from prototypes as well as general considerations that apply to a wider range of system architectures. Specifically, we investigate the suitability of NP for QoS (active queue management and traffic engineering), header processing (GPRS tunneling protocol), intelligent forwarding (load balancing without flow disruption), payload processing (code interpretation and just-in-time compilation in active networks), and protocol stack termination (SCTP). Finally, we summarize the key features as revealed by each case study, and conclude with remarks on the future of NP. 相似文献
888.
889.
Contactless methods were used to study the characteristics of the front and rear sides of single-crystal GaAs wafers whose rear side was irradiated with low-energy Ar ions. Variations in the optical and photoelectric properties of irradiated and unirradiated sides were detected. A solitonic mechanism for the penetration of defects into the crystal bulk is suggested. 相似文献
890.
We report on the observation of localized states (LSs) in a single-mirror feedback system using sodium vapor as the nonlinear medium. By combining experimental results with simulations based on a microscopic model and with results of a linear stability analysis of the homogeneous state, we discuss the properties of the LSs, the mechanism of their formation, their domain of existence in parameter space, their interaction with the amplitude and phase gradient in the Gaussian beam of the driving laser, and the formation of "molecules" and "clusters" of LSs. We elucidate the dominant role of diffraction in the interaction of the LSs and discuss relations between the clusters of LSs and extended patterns. 相似文献