SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome

A drug with cationic characteristics such as procaine can be conveyed in a Carbomer hydrogel in two different ways: (i) in the form of salt in solution in the aqueous phase, and (ii) in the base form salified with the same polymer. Introduction of the drug into the hydrogel with different concentrations of polymer produced, in both cases, a reduction in viscosity in relation to drug concentration. The gels with procaine salified with the polymer showed greater viscosity. The drug release rate, in general, diminished with the increase in polymer concentration. Nevertheless, when this concentration was maintained, there was no variation in release rate when the viscosity produced as a consequence of drug concentration was changed. Gels with procaine salified with the carboxyvinylic polymer had a faster release rate than those with procaine in the hydrochloride form dissolved in the aqueous phase. These results have also been confirmed by a simulated absorption test.     

聚乙烯接枝改性及其与铝的粘结性

聚乙烯在过氧化二异丙苯存在下分别与丙烯酸，顺丁烯酸酐，顺丁烯二酸，顺丁烯二酸钠，丙烯酸羧丙酯，甲基丙烯酸环丙酯等单体熔融挤出，产物的红外光谱表明聚乙烯不同程度地接了各种极性基团。     

原子力显微术

本文首先介绍了原子力显微术的基本理论，其次讨论了原子力显微镜的结构原理，主要报导了一台我们研制的使用光学偏转法检测的原子力显微镜及仪器性能，仪器测试的结果表明我们这台原子力显微镜获得了原子分辨率，最后给出使用这台显微镜的首批实验结果。     

环形转底炉海绵铁生产方法

介绍了国内外环形转炉生产海绵铁方法（Ｆａｓｔｍｅｔ法，Ｉｎｍｅｔｃｏ法和ＣＯＦ－Ｒ）发展状况。分析了此种工艺的工艺特点和热工特点，指出了这种方法与回转窑法，遂道窑法比较具有强大的市场竞争力。     

面向对象方法在7号信令软件设计中的应用

随着交换技术的飞速发展，程控交换软件的规模越来越大，改动也越来越频繁，如何使代码对数据的改动具有相对的稳定性成为程控软件设计的一个首要问题。本文以ＣＣＳ７（７号公共信道信令）为例，从对象模型、动态模型、功能模型３个方面阐述了ＯＯ（面向对象）方法在ＣＣＳ７软件设计中的应用。这一方法，也可应用于程控软件的设计。     

天津市正常人全血和血清微量元素含量分析

人体内微量元素含量平衡与否与人体健康状态有着密切关系已为大量实践所证实。人体血液中微量元素的正常值测定是研究人体健康与微量元素关系的一项基础性工作,本文提供了天津市正常人全血及血清中几种微量元素含量的数据。     

“双驱动足”回转式压电马达初步研究

提出一种“双驱动足”回转式压电马达，分析了其工作原理，并根据工作原理，设计，研制了样机，进行了初步的试验研究，证明工作原理基本正确，为今后进一步研究提供了参考依据。     

Synthesis and biological activities of phenyl piperazine-based peptidomimetic growth hormone secretagogues

A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substituent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC50 = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.     

Calcium-sensitive fluorescent dyes can report increases in intracellular free zinc concentration in cultured forebrain neurons

High concentrations of Zn2+ are found in presynaptic terminals of excitatory neurons in the CNS. Zn2+ can be released during synaptic activity and modulate postsynaptic receptors, but little is known about the possibility that Zn2+ may enter postsynaptic cells and produce dynamic changes in the intracellular Zn2+ concentration ([Zn2+]i). We used fura-2 and magfura-2 to detect the consequences of Zn2+ influx in cultured neurons under conditions that restrict changes in intracellular Ca2+ and Mg2+ concentrations. The resulting ratio changes for both dyes were reversed completely by the Zn2+ chelator, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine, indicating that these dyes are measuring changes in [Zn2+]i. We found that fura-2 was useful in measuring small increases in [Zn2+]i associated with exposure to Zn2+ alone that may be mediated by a Na+/Ca2+ exchanger. Magfura-2, which has a lower affinity for Zn2+, was more useful in measuring larger agonist-stimulated increases in [Zn2+]i. The coapplication of 300 microM Zn2+ and 100 microM glutamate/10 microM glycine resulted in a [Zn2+]i increase that was approximately 40-100 nM in magnitude and could be inhibited by the NMDA receptor antagonist, MK-801 (30 microM), or extracellular Na+. This suggests that Zn2+ influx can occur through at least two different pathways, leading to varying increases in [Zn2+]i. These findings demonstrate the feasibility of measuring changes in [Zn2+]i in neurons.