Early and intensive physiotherapy accelerates recovery postarthroscopic meniscectomy: results of a randomized controlled study

The efficacy of an early, intensive, supervised rehabilitation program to accelerate knee strength recovery in the first 3 weeks postmeniscectomy by arthroscopy was evaluated using a randomized controlled trial design. The maximal voluntary isokinetic strength of 31 men, randomly allocated to either a treatment (EXP) or a control (CTL) group, was measured twice by a blind rater: preoperatively (pretest) and 3 weeks postsurgery (posttest), using a computer-controlled Kin-Com dynamometer (Chattecx Corporation, Chattanooga, TN). Strength deficits of the operated leg at the pretest and posttest were established in percent of the values obtained for the sound leg at the pretest. In the interval between the surgery and the posttest, the patients of the EXP group (n = 15) received nine supervised treatments combined to home exercises whereas patients of the control group (n = 16) had no specific physiotherapy treatment but were given instructions in postsurgical management and prescribed exercises by the orthopedic surgeons. Patients of the EXP group had better knee extensor strength recovery than patients of the CTL group (ANCOVA, p < 0.001). The size of the strength difference (3 weeks postsurgery) between EXP and CTL subgroups (n = 8) matched according to preoperative deficits was as large as 26% and the residual deficits of the untreated patients were two to three times larger than those of the treated patients. The results of this study highlight the importance of instituting an early intensive and supervised rehabilitation program, especially for workers returning to a strenuous job requiring good knee extensor muscle function.     

Inhibition of plasma membrane Ca(2+)-ATPase activity by volatile anesthetics

BACKGROUND: The precise sites and mechanisms of action of volatile anesthetics remain unknown. Recently, several integral membrane proteins have been suggested as potential targets to which anesthetics can bind at hydrophobic regions. Impairment of cell Ca2+ homeostasis has been postulated as one of the possible mechanisms of anesthetic action. To test these hypotheses, the authors selected the human erythrocyte Ca(2+)-ATPase as a model membrane protein. This enzyme is an integral membrane protein that is instrumental in maintaining Ca2+ homeostasis in the cell in which it is the sole Ca(2+)-transporting system. Thus, any functional alteration of the Ca(2+)-ATPase by anesthetics may lead to serious perturbations in Ca(2+)-regulated processes in the cell. METHODS: The Ca(2+)-ATPase activity was measured as a function of increased concentration of four volatile anesthetics: halothane, isoflurane, enflurane, and desflurane. RESULTS: All four anesthetics significantly inhibited the Ca(2+)-ATPase activity in a dose-dependent manner. The half-maximal inhibition occurred at anesthetic concentrations from 0.3 to 0.7 vol% at 37 degrees C, which, except for desflurane, is a clinically relevant concentration range. The greater the clinical potency of the volatile anesthetics studied, the less was the concentration required to inhibit the Ca(2+)-ATPase activity. The inhibition was less at 25 degrees C than at 37 degrees C, which is consistent with direct interactions of the nonpolar interfaces of the enzyme with the nonpolar of the portions of the anesthetics. CONCLUSIONS: The authors' findings indicate that the Ca(2+)-ATPase is a suitable model for investigating the mechanism of action of volatile anesthetics on the integral membrane protein, and that this inhibition may be specific.     

Chemical activation of the SHS process in the Nb−C system

The phenomenon of chemical activation is investigated using combustion of the Nb–C system in the presence of an activating additive, namely, polytetrafluoroethylene, as an example. Regions of the parameters of the process are found where the interaction occurs by two different mechanisms. The characteristic features of the process are established and the role of the activating additive in each region is determined.Institute of Chemical Physics, Academy of Sciences of Armenia, Yerevan. Translated from Inzhenerno-Fizicheskii Zhurnal, Vol. 65, No.5, pp.590–593, November, 1993.     

Optimization of parameters of recirculating apparatus for obtaining liquid nitrogen using mixtures

Translated from Khimicheskoe i Neftyanoe Mashinostroenie, No. 12, pp. 20–23, December, 1993.     

A novel four-point bend test for strength measurement of opticalfibers and thin beams. II. Statistical analysis

In the first part of this work, a novel implementation of the well-known four-point bend test is described that determines the strength of thin beams and optical fibers by measuring the loading pin displacement, rather than the applied load. This paper extends the analysis of the nonlinear bending behavior to account for the stochastic nature of strength. A statistical analysis is presented that determines the effective tested length in bending and the tension to bending strength ratio. Results are given for both surface and volume flaws as well as for specimens of both circular and rectangular section. Strength measurements on a deliberately weakened silica optical fiber are consistent with the predictions of the analysis     

Oxidant damage to erythrocyte membrane in glucose-6-phosphate dehydrogenase deficiency: correlation with in vivo reduced glutathione concentration and membrane protein oxidation

Chronic nonspherocytic hemolytic anemia has been observed in a recently described glucose-6-phosphate dehydrogenase (G6PD) variant, G6PDWayne. The mechanical properties of these erythrocytes and other G6PD variants were examined. The deformability of G6PD-deficient erythrocytes was normal, as determined by osmotic scan ektacytometry, and was not significantly affected by hemolytic crisis. In the common varieties of G6PD deficiency, the mechanical stability of the red blood cell (RBC) membrane was greater than normal, but G6PDWayne membranes were abnormally susceptible to shear-induced fragmentation. There was no evidence for a concurrent genetic defect in spectrin, because self-association constants and tryptic digests were normal. The fragility of G6PDWayne membranes appeared to be a consequence of oxidative damage to membrane thiol groups associated with a low glutathione (GSH) level in these RBCs. Associations among GSH level, thiol oxidation, and membrane instability were also found when a larger group of G6PD-deficient RBCs were examined. In normal erythrocytes, 1-chloro-2,4-dinitrobenzene was used to reduce GSH levels by 50%. Membrane thiol oxidation and membrane fragility both increased when these cells were kept at 4 degrees C for 3 to 5 days. Our findings suggest that chronic depletion of GSH leads to the destabilization of membrane skeleton through oxidation of membrane protein thiols.     

On the Finite-Time Stabilization of Uncertain Nonlinear Systems With Relative Degree Three

This technical note discusses a finite-time stabilization problem in a nonlinear, uncertain, environment. The main result of the present note is presented making reference to a triple integrator affected by bounded uncertainties and subject to ldquohardrdquo measurement nonlinearities such that the sign of the state variables is the only reliable information available for feedback. We propose a discontinuous control scheme guaranteeing the practical finite-time annihilation of the three state variables. Constructive proof and computer simulations, as well as guidelines for practical implementations, are provided throughout this technical note.     

Thermodynamics of chemical and electrochemical stability of brasses

Based on the theory of “regular” solutions, the thermodynamic properties of α-, β-, γ-, ɛ-, and η-phases of the Cu-Zn system are described. The surface activity of the elements in the phases is assessed. Potential-pH diagrams for the general system Cu-Zn-H₂O and the manganese brass system H₂O at 25°C are plotted. The nature of passivating films on conventional and special brasses and their composition are elucidated in different pH and potential ranges.     

A Simulation Environment for e-Learning in Digital Design

Deeds is a simulation environment for e-learning in digital electronics. The simulators cover combinational and sequential logic networks, finite state-machine design, and microcomputer interfacing and programming. They are integrated together, and therefore allow the design and test of embedded digital systems. The environment guides students' activities by delivering learning materials through specialized browsers. An extensive collection of learning materials is available. This paper includes an example of activity on a problem assignment.