Therapeutic Effects of Insulin-Producing Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Type 1 Diabetes Mouse Model

In patients with type 1 diabetes (T1D), compromised pancreatic β-cell functions are compensated through daily insulin injections or the transplantation of pancreatic tissue or islet cells. However, both approaches are associated with specific challenges. The transplantation of mesenchymal stem cells (MSCs) represents a potential alternative, as MSCs have tissue-forming capacity and can be isolated from various tissues. The human umbilical cord (hUC) is a good source of freely available MSCs, which can be collected through pain-free, non-invasive methods subject to minimal ethical concerns. We sought to develop a method for the in vitro generation of insulin-producing cells (IPCs) using MSCs. We examined the potential therapeutic uses and efficacy of IPCs generated from hUC-derived MSCs (hUC-IPCs) and human adipose tissue (hAD)-derived MSCs (hAD-IPCs) through in vitro experiments and streptozotocin (STZ)-induced C57BL/6 T1D mouse models. We discovered that compared to hAD-IPCs, hUC-IPCs exhibited a superior insulin secretion capacity. Therefore, hUC-IPCs were selected as candidates for T1D cell therapy in mice. Fasting glucose and intraperitoneal glucose tolerance test levels were lower in hUC-IPC-transplanted mice than in T1D control mice and hAD-IPC-transplanted mice. Our findings support the potential use of MSCs for the treatment of T1D.     

A new methodology for identification of critical lines using damping sensitivity analysis

When an inter-area mode dominates a low-frequency oscillation in a stressed condition, control of the active power flow of interface lines, with compensating devices, can effectively reduce the electromechanical power oscillations. In general, interface lines in which inter-area oscillations are large are considered to be good locations for installation of compensating devices. A sensitivity analysis with respect to change in active power flow can provide an important factor in electric power system operation. This paper proposes a new methodology to calculate the damping sensitivity with respect to change in active power flow, which can be useful for accurate selection of critical lines from the viewpoint of small-signal stability. In the proposed methodology, a damping sensitivity index is used to select the critical lines to damp power system oscillations. This paper describes how to derive the damping sensitivity for the selected mode and illustrates an example applying the proposed algorithm to a simple two-area system and the New England 39-bus test system.     

Morphology-based approaches for detecting stream channels from ALSM data

To map the Earth's surface at remarkable resolution, Airborne Laser Swath Mapping (ALSM) instrument technology and subsequent algorithms have been used over the last several years. Since forested watersheds have commonly been problematic to study with remote sensing techniques, the ability of ALSM technology to densely sample ground elevations beneath forest canopies is especially considerable. Stream network detection from digital elevation models (DEMs) is a key role in modelling spatially distributed hydrological processes. To detect stream channels, we have developed two approaches. The first approach is based on an encoding of mathematical morphological operators. In the second approach, a composition of geodesic top-hat and bot-hat operations of different sizes is used in order to build a morphological profile (P _M) that records the image structural information. The two proposed methods perform well in terms of detection results and classification accuracies. The second approach is more general than the first, but it also requires training and more computation.     

Motivations for Open Source Project Participation and Decisions of Software Developers

We provide a rationale for open source project participation by studying the decision problems of the software programmers, whose types are different in terms of ability and intrinsic motivation. We find that motivations, both intrinsic and extrinsic, and the ability level positively affect the optimal level of effort exerted by the programmers in the open source project. In the commercial project, the programmers with higher ability exert much effort although their high level of effort is not compensated properly. Thus, the open source project might be more likely to attract capable and motivated programmers than the commercial project.     

A study on the optimization of KCI-based index (Kor-Factor) in evaluating Korean journals

This study describes the development process of Kor-Factor, which is a novel composite evaluation index that was developed to promote Korean domestic academic journals. As more data accumulate, the Kor-Factor’s optimization process was modified in an attempt to address possible drawbacks of the original form; the result is presented in this study. This study compares Kor-Factor with the Impact Factor, which is the most well-known single element evaluation index. We found that Kor-Factor demonstrates a better power of differentiation and a greater capacity to reflect the reputability of key journals. The modified Kor-Factor, which has been developed through an optimization process, reveals a greater power of differentiation than the original Kor-Factor; however, the modified version has less capacity to reflect reputability. The evaluation elements of the modified Kor-Factor are better and are more evenly reflected on the index value than those of the original version. Finally, we propose the establishment of an appropriate data measurement period for the actual application of the index.     

Preparation and photoluminescence properties of γ-KCaPO4: Eu phosphors for near UV-based white LEDs

Novel whitish-blue phosphors based on a phosphate host matrix, γ-KCaPO₄: Eu²⁺, were prepared by a conventional solid-state reaction method using slightly phosphorus deficient conditions and their photoluminescence properties were investigated. The concentration quenching process, temperature dependence of the luminescence and decay curve were also investigated. The γ-KCaPO₄: Eu²⁺ phosphor was efficiently excited by UV-Visible light at wavelengths of 200-450 nm and exhibited a bright whitish-blue emission with a maximum peak wavelength of 473 nm. All of these characteristics suggest that the γ-KCaPO₄: Eu²⁺ phosphors combined with red phosphors could be applicable to near UV-based white LEDs, i.e., only two kinds of phosphor powders are needed for the formation of white light.     

A 2.4-GHz dual-mode 0.18-/spl mu/m CMOS transceiver for Bluetooth and 802.11b

High-level integration of the Bluetooth and 802.11b WLAN radio systems in the 2.4-GHz ISM band is demonstrated in scaled CMOS. A dual-mode RF transceiver IC implements all transmit and receive functions including the low-noise amplifier (LNA), 0-dBm power amplifier, up/down mixers, synthesizers, channel filtering, and limiting/automatic gain control for both standards in a single chip without doubling the required silicon area to reduce the combined system cost. This is achieved by sharing the frequency up/down conversion circuits in the RF section and performing the required baseband channel filtering and gain functions with just one set of reconfigurable channel filter and amplifier for both modes. A chip implemented in 0.18-/spl mu/m CMOS occupies 4/spl times/4 mm/sup 2/ including pad and consumes 60 and 40 mA for RX and TX modes, respectively. The dual-mode receiver exhibits -80-dBm sensitivity at 0.1% BER in Bluetooth mode and at 12-dB SNR in WLAN mode.     

Cooperative detection and protection for Interest flooding attacks in named data networking

Named data networking (NDN) is a new emerging architecture for future network, which may be a substitute of the current TCP/IP‐based network, for the content‐oriented data request mode becoming the future trend of development. The security of NDN has attracted much attention, as an implementation of next‐generation Internet architecture. Although NDN is immune to most current attack, it cannot resist the distributed denial of service like attack – Interest flooding attack (IFA) – effectively. IFA takes advantages of the forwarding mechanism of NDN, flooding a large number of malicious Interest packets at quite a high rate, and exploits the network resources, which may cause the paralysis of the network. Taking into account the severity of the destruction, we propose an algorithm to counter such new type of attack. We analyze three properties of IFA, and use them to judge and filter Interest packets. Vector space model and Markov model are used in our method to realize a cooperative detection. Meanwhile, we present the retransmission forwarding mechanism to ensure legitimate user request. The ndnSIM module of ns3 is used for the corresponding simulation, and results of the simulation will be given to show the effectiveness of our algorithm. Copyright © 2014 John Wiley & Sons, Ltd.     

CPW bandstop filter using slot-type SRRs

The bandstop characteristic of a slot-type split-ring resonator (SRR) on a substrate used for microwave frequencies is presented for a bandstop filter. Analogously to the conventional strip-type SRR, the slot-type SRR is very attractive for notching unwanted band because of its small dimension and high Q operation. In addition, the complementary SRR can be easily applied for coplanar configuration, which is favourable to MMIC designs. Based on the simulation and measurement results, the slot-type SRR for the bandstop filter is very effective in rejecting unwanted frequency in terms of its selectivity and size.