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41.
The present study determined tumorigenicity, tumor classification and DNA damage induced in infant mice by benzo[a]pyrene (B[a]P) or Manufactured Gas Plant (MGP) residues after a single exposure. Male and female B6C3F1 mice were exposed to B[a]P or MGP residue from a single environmental site (MGP-4) and males were also exposed to MGP residue composite from seven different sites (MGP-M7). At 26, 39 and 52 weeks after exposure tumorigenesis was assessed in lung, forestomach and liver. Formation and persistence of DNA adducts were quantified by 32P-postlabeling. Exposure of males to B[a]P induced liver tumors in a dose and time dependent manner. MGP induced more advanced tumors than B[a]P. Only a single liver tumor was found in MGP-4 treated females. No forestomach and few pulmonary adenomas were induced in males or females. MGP-4, MGP-M7 or B[a]P induced DNA adducts in males and females. Adducts in liver, lung and forestomach peaked on different days and decreased at different rates. At 24 h post-exposure, no significant differences in initial DNA adduct levels occurred in males and females exposed to MGP-4 or B[a]P. Lack of DNA damage (adducted DNA) did not account for non-responsiveness of lung and forestomach in B6C3F1 genders as well as in liver in females. MGP tumorigenicity could not be accounted for solely by B[a]P content nor did it reflect additivity of B[a]P and other carcinogenic polycyclic aromatic hydrocarbons (PAHs) in MGP. Synergy among MGP-PAHs, presence of unidentified carcinogens and/or promoters in MGP may account for MGP potency. The B6C3F1 infant male model is a convenient and rapid assay for assessing MGP liver tumorigenicity and potency. 相似文献
42.
43.
Prof. Dipl.-Ing. Dr.techn. Walter Gretler Prof. Dr. Si-min Zeng 《Forschung im Ingenieurwesen》1996,62(5):105-115
A numerical simulation of unsteady compressible flow induced by two high-speed trains in oncoming traffic within a tunnel
is presented. The computations were carried out by means of a second-order accurate Harten-Yee type upwind TVD scheme. In
order to take the effect of friction into account, a source term is included in the governing flow equations. In the computation,
moving boundary configurations were used to simulate the two trains passing through the tunnel. As geometrical configuration,
the Einmalberg tunnel, where experimental data are available, was selected. The computational results agree reasonably well
with their experimental counter-part. The waves interaction and the waves propagation process at the tunnel entrance and exit
as well as within the tunnel are addressed. Finally, the influence on the transmitted waves at the tunnel exit portal and
the variation of the negative pressure drop during the passage of the two trains are discussed. 相似文献
44.
液相添加剂对PTCR陶瓷电性能的影响 总被引:3,自引:2,他引:1
液相添加剂AST(Al2O3+SiO2+TiO2)对BaTiO3陶瓷材料电性能的影响很大,随着Al2O3含量的增加,材料的电性能降低;SiO2、TiO2的物理特性对材料电性能影响较大;过量TiO2对材料PTC效应有重要影响,适当过量TiO2含量,可得到性能优良的PTCR陶瓷。 相似文献
45.
46.
本文介绍了一些国内原有的及近年来发展的用于石材开采的成型爆破方法,简单扼要地阐明了这些方法的原理、装药结构及主要特点,对全面认识及合理选择这些方法有一定帮助。 相似文献
47.
This case report describes an accessory hepatic duct (AHD) identified by intraoperative cholangiography during excisional surgery of a choledochal cyst (CC). The accessory duct was divided and reconstructed successfully to the Roux-en-Y jejunal loop. The postoperative course was uneventful, and follow-up abdominal sonography revealed neither evidence of biliary tract obstruction nor atrophic changes of the liver. It is advocated that an AHD should be meticulously reconstructed if it is divided during excisional surgery of a CC. 相似文献
48.
机械合金化Fe50Ti50非晶的形成及球磨强度对它的影响 总被引:3,自引:0,他引:3
本文通过电子扫描和X衍射对机械合金人Fe50Ti50非晶粉末形成做了研究。研究发现:机械合金非晶形成可以大致地分为二个阶段-粉末的破碎阶段和非晶的形成阶段。另外,对球磨强度对非晶形成的影响进行了研究。结果表明:强度低时粉末需要较长的时间才能形成非晶,强度高时粉末形成非晶的时间大大缩短,但在随后的球磨中,粉末会重新晶化形成新相。 相似文献
49.
50.
X. X. Xi X. H. Zeng A. V. Pogrebnyakov A. Soukiassian S. Y. Xu Y. F. Hu E. Wertz Q. Li Y. Zhong C. O. Brubaker Z.-K. Liu E. M. Lysczek J. M. Redwing J. Lettieri D. G. Schlom W. Tian H. P. Sun X. Q. Pan 《Journal of Superconductivity and Novel Magnetism》2003,16(5):801-806
The recently discovered superconductor MgB2 with T c at 39 K has great potential in superconducting electronics. In this paper, we review the deposition techniques used for MgB2 thin films in the light of a thermodynamic study of the Mg-B system with the calculation of phase diagrams (CALPHAD) modeling technique. This thermodynamic study identifies a growth window in the pressure–temperature phase diagram, in which the magnesium pressure is very high for likely in situ growth temperatures. A Hybrid Physical–Chemical Vapor Deposition (HPCVD) technique that successfully achieves such a high Mg pressure is shown to produce in situ epitaxial MgB2 thin films with bulk superconducting properties. 相似文献