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31.
Sachi Oshima Shunichi Asai Naohiko Seki Chikashi Minemura Takashi Kinoshita Yusuke Goto Naoko Kikkawa Shogo Moriya Atsushi Kasamatsu Toyoyuki Hanazawa Katsuhiro Uzawa 《International journal of molecular sciences》2021,22(12)
We identified the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC) tissues by RNA sequencing, in which 168 miRNAs were significantly upregulated, including both strands of the miR-31 duplex (miR-31-5p and miR-31-3p). The aims of this study were to identify networks of tumor suppressor genes regulated by miR-31-5p and miR-31-3p in HNSCC cells. Our functional assays showed that inhibition of miR-31-5p and miR-31-3p attenuated cancer cell malignant phenotypes (cell proliferation, migration, and invasion), suggesting that they had oncogenic potential in HNSCC cells. Our in silico analysis revealed 146 genes regulated by miR-31 in HNSCC cells. Among these targets, the low expression of seven genes (miR-31-5p targets: CACNB2 and IL34; miR-31-3p targets: CGNL1, CNTN3, GAS7, HOPX, and PBX1) was closely associated with poor prognosis in HNSCC. According to multivariate Cox regression analyses, the expression levels of five of those genes (CACNB2: p = 0.0189; IL34: p = 0.0425; CGNL1: p = 0.0014; CNTN3: p = 0.0304; and GAS7: p = 0.0412) were independent prognostic factors in patients with HNSCC. Our miRNA signature and miRNA-based approach will provide new insights into the molecular pathogenesis of HNSCC. 相似文献
32.
Dr. Daisuke Fujiwara Kousuke Mihara Ryo Takayama Yusuke Nakamura Prof. Mitsuhiro Ueda Prof. Takeshi Tsumuraya Prof. Ikuo Fujii 《Chembiochem : a European journal of chemical biology》2021,22(24):3406-3409
Conformationally constrained peptides hold promise as molecular tools in chemical biology and as a new modality in drug discovery. The construction and screening of a target-focused library could be a promising approach for the generation of de novo ligands or inhibitors against target proteins. Here, we have prepared a protein kinase-focused library by chemically modifying helix-loop-helix (HLH) peptides displayed on phage and subsequently tethered to adenosine. The library was screened against aurora kinase A (AurA). The selected HLH peptide Bip - 3 retained the α-helical structure and bound to AurA with a KD value of 13.7 μM. Bip - 3 and the adenosine-tethered peptide Bip - 3 - Adc provided IC50 values of 103 μM and 7.7 μM, respectively, suggesting that Bip - 3 - Adc bivalently inhibited AurA. In addition, the selectivity of Bip - 3 - Adc to several protein kinases was tested, and was highest against AurA. These results demonstrate that chemical modification can enable the construction of a kinase-focused library of phage-displayed HLH peptides. 相似文献
33.
K. A. Khor F. Y. C. Boey Y. Murakoshi T. Sano 《Journal of Thermal Spray Technology》1994,3(2):162-168
There has been increasing use of Al-Li alloys in the aerospace industry, due mainly to the low density and high elastic modulus
of this material. However, the problem of low ductility and fracture toughness of this material has limited its present application
to only weight- and stiffness-critical components. Development of Al-Li/ceramic composites is currently being investigated
to enhance the service capabilities of this material. The Ti-Al alloy is also of interest to aerospace-type applications,
engine components in particular, due to its attractive high-temperature properties. Preparation of fine powders by plasma
melting of composite feedstock and coatings formed by plasma spraying was carried out to examine the effect of spray parameters
on the microstructure and properties of these materials. Characterization of the powders and coatings was performed using
the scanning electron microscope and image analyzer. Examination of the plasma-sprayed powders and coatings has shown that
in the Al-Li/SiC composite there is melting of both materials to form a single composite particle. The SiC reinforcement was
in the submicron range and contributed to additional strengthening of the composite body, which was formed by a cold isostatic
press and consolidated by hot extrusion or hot forging processes. The plasma-sprayed Ti-Al powder showed four categories of
microstructures: featureless, dendritic, cellular, and martensite-like. 相似文献
34.
Copoly(amide-ethers) containing two types of tertiary amine units were made as antistatic modifiers for poly(ethylene terephthalate) (PET) fibers. The filaments of the copolymers were melt-spun and reacted with three alkylating agents in order to quaternize the tertiary amine into a sulfo-betaine, a carbobetaine, and an ammonium ion. The apparent electric resistivity of the filaments was greatly reduced by this reaction, being in the range of 106 to 108 Ω/cm. However, because these quaternized copolymers incurred decomposition during blend spinning with PET, a blend PET fiber containing one type of copoly(amide-ether) was melt-spun and subjected to quaternization of the amino groups as well as to surface crosslinking with various alkylating and epoxy agents. The quaternized blend fibers obtained showed improved antistatic properties compared with the original blend fiber. Particularly, the fibers crosslinked with epoxy compounds were found to have the best antistatic properties that had ever been attained with this type of modification. The antistatic properties were retained even after dyeing, because both hydrophilic and ionic groups had been effectively immobilized on the surface. Since this quaternization and crosslinking could be conducted on-line with spinning and drawing within a short reaction time, this modification technique is called “spin-finishing method”, which should be superior to the conventional methods in terms of cost performance and productivity. 相似文献
35.
Takashi Hayakawa Hideo Orita Masao Shimizu Katsuomi Takehira Arnfinn G. Andersen Kiyoshi Nomura Yusuke Ujihira 《Catalysis Letters》1992,16(4):359-371
The catalytic activity of LaCoO3–-based mixed oxides for the oxidative coupling of methane has been tested by TPR and cyclic reaction. Characterization has been done by XRD, TGA and Mössbauer spectrometry. It is likely that the perovskite-crystal structure containing hypervalent metal ions has an important role and that unique structural oxygen species in the perovskite contribute to the partial oxidation of methane. 相似文献
36.
Norikazu Nishiyama Tao Zheng Yusuke Yamane Yasuyuki Egashira Korekazu Ueyama 《Carbon》2005,43(2):269-274
Microporous carbons have been synthesized by the carbonization of cationic surfactant-resorcinol/formaldehyde (RF) composites, which were themselves formed by electrostatic organic-organic interaction. The porous structure produced by the decomposition of the surfactant plays an important role for the gasification of the RF polymer at higher temperatures. The pore size of the carbon prepared from tetrapropylammonium bromide (TPAB)-RF, cetyltrimethylammonium bromide (C16TAB)-RF and decyltrimethylammonium bromide (C10TAB)-RF mixtures can be estimated as 0.53 nm from the Horvath-Kawazoe method using N2 adsorption isotherms. Their pore size distributions were very narrow, showing that the microporous carbons derived from surfactant-RF mixture may have promise as adsorbents and membrane materials. 相似文献
37.
Summary Several metal oxides-supported TiCl3 catalysts were prepared and propylene polymerization was conducted over them without cocatalysts. It was found that isotactic polymerization of propylene took place effectively over them. 相似文献
38.
Summary It was found that isotactic polymerization of propylene took place over titanium ion-exchanged Y-zeolite without organometallic compounds. The results obtained have led to the conclusions that Ti4+ species as well as Ti3+ species are active for the polymerization and that neither Ti-alkyl bonds nor Cl ligands are necessarily essential for polymerization of propylene. 相似文献
39.
Yoshihiro Kubota Yusuke Nishizaki Hisanori Ikeya Masami Saeki Tetsunari Hida Sachiko Kawazu Michitaka Yoshida Hidekazu Fujii Yoshihiro Sugi 《Microporous and mesoporous materials》2004,70(1-3):135-149
Two types of organic–inorganic hybrid base catalysts are prepared. Organic-functionalized molecular sieves (OFMSs), particularly “amine-immobilized porous silicates”, are designed based on common idea to immobilize catalytic active sites on silicate surface. Silicate–organic composite materials (SOCMs), such as “ordered porous silicate–quaternary ammonium composite materials”, are the precursors of ordered porous silicates obtained during the synthesis. Both the OFMS and the SOCM are used as the catalysts for Knoevenagel condensation. Among the OFMSs, there is clear tendency that the use of molecular sieve with larger pore volume and/or surface area gives the product in higher yield. Aminopropylsilyl (AP)-functionalized mesoporous silicates such as AP-MCM-41 gives the product in high yield under mild conditions. No loss of activity is observed after repeated use for three times. The SOCMs are also active for the same reaction. The precursors of the mesoporous silicates are more active than those of microporous silicates. This material can be repeatedly used without significant loss of activity. High activity is not due to the leached species. The active sites of the SOCM catalysts are considered to be SiO− moieties located on the pore-mouth. Activity of the SOCM increases when the reaction is carried out without solvent, whereas decrease in activity of the OFMS is observed in the solvent-free system. 相似文献
40.
Chengzhou Li Yusuke Imai Yoshio Adachi Hiroshi Yamada Keiko Nishikubo Chao-Nan Xu 《Journal of the American Ceramic Society》2007,90(7):2273-2275
An organic aqueous solution of metal acetylacetonate precursors was subjected to spray pyrolysis in order to fabricate SrAl2 O4 :Eu (SAO) nanoparticles. Non-agglomerated luminescent SAO nanoparticles, having a spherical shape with a size of 10–30 nm, were achieved in a single step, while only submicrometer-sized SAO particles were obtained from the conventional ultrasonic pyrolysis of the metal nitrates. Without any post-annealing process, the as-prepared SAO nanoparticles were observed to exhibit a strong photoluminescence, which is comparable with that of the submicrometer-sized SAO particles. A mechanism for the formation of the nanoparticles is also discussed. 相似文献