Metal-polyphenol-network coated CaCO3 as pH-responsive nanocarriers to enable effective intratumoral penetration and reversal of multidrug resistance for augmented cancer treatments

Construction of multifunctional stimuli-responsive nanotherapeutics enabling improved intratumoral penetration of therapeutics and reversal of multiple-drug resistance (MDR) is potent to achieve effective cancer treatment. Herein, we report a general method to synthesize pH-dissociable calcium carbonate (CaCO₃) hollow nanoparticles with amorphous CaCO₃ as the template, gallic acid (GA) as the organic ligand, and ferrous ions as the metallic center via a one-pot coordination reaction. The obtained GA–Fe@CaCO₃ exhibits high loading efficiencies to both oxidized cisplatin prodrug and doxorubicin, yielding drug loaded GA–Fe@CaCO₃ nanotherapeutics featured in pH-responsive size shrinkage, drug release, and Fenton catalytic activity. Compared to nonresponsive GA–Fe@silica nanoparticles prepared with silica nanoparticles as the template, such GA–Fe@CaCO₃ confers significantly improved intratumoral penetration capacity. Moreover, both types of drug-loaded GA–Fe@CaCO₃ nanotherapeutics exhibit synergistic therapeutic efficacies to corresponding MDR cancer cells because of the GA–Fe mediated intracellular oxidative stress amplification that could reduce the efflux of engulfed drugs by impairing the mitochondrial-mediated production of adenosine triphosphate (ATP). As a result, it is found that the doxorubicin loaded GA–Fe@CaCO₃ exhibits superior therapeutic effect towards doxorubicin-resistant 4T1 breast tumors via combined chemodynamic and chemo-therapies. This work highlights the preparation of pH-dissociable CaCO₃-based nanotherapeutics to enable effective tumor penetration for enhanced treatment of drug-resistant tumors.

     

一种新的解映射算法的推导和实现

本文在一种16QAM,64QAM,256QAM的解映射算法启发下,提出了新的适合32QAM和128QAM的解映射算法,并在此基础上,给出了适合DVB-C接收机的多QAM解映射结构.然后在FPGA中实现和仿真.最后通过比较说明,相对于传统的查找表解映射方法,提出的解映射算法可以明显减少资源使用率.     

泥页岩井壁稳定研究及在临盘地区的应用

从岩石力学和物理化学两个主要因素简要分析了井壁失稳的机理，指出泥页岩井壁失稳是由力学与化学两方面因素共同作用的结果。钻井液与泥页岩存在化学势差，并改变了井壁附近的孔隙压力，降低岩石强度。借助于井壁处有效应力的变化,将泥页岩与钻井液相互作用时页岩水化所产生的力学效应与纯力学效应结合起来，计算出任意井斜方位井眼围岩应力状态，利用测井资料求出有关岩石力学参数和Mohr Couloumb准则，计算得出防塌的临界钻井液密度。     

四川盆地及邻区上二叠统一下三叠统海槽的深水沉积特征

四川盆地及邻区广元-旺苍、城口-鄂西、开江-梁平海槽是上二叠统一下三叠统飞仙关组（P3-T1f）的深水碳酸盐沉积区。该区上二叠统上部大隆组是硅质岩、硅质泥岩、硅质灰岩组合，含放射虫、有孔虫等化石，厚125—29．0m，为海槽裂陷期凝缩沉积。三叠系飞仙关组下部为远洋沉积的暗色泥岩、微晶碎屑灰岩和重力流沉积的浊积岩、角砾灰岩组成的深水碳酸盐沉积，厚50．0～300．0m，是裂陷期后的海槽充填沉积。海槽相区沉积在晚二叠统世末达到最大海泛面沉积了大隆组。海平面缓慢下降期沉积了补偿充填性质的飞仙关组深水碳酸盐岩。海槽相区上二叠统一下三叠统飞仙关组构成了一个完整的三级层序。深水沉积物的有机碳平均值高达6．21％，是良好的烃源岩。但在海槽相区上二叠统不发育生物礁，飞仙关组缺乏鲕粒岩。     

控制爆破在复杂基坑开挖中的应用

在紧邻厂房中控室的基坑开挖中，根据复杂环境条件与施工要求，采用浅孔微差爆破并通过选取合理开沟掏槽位置来控制最小抵抗线方向以及控制一次最大起爆药量等措施，达到了控制飞石、降低爆破地震的效果，保证了爆破质量与爆破安全，提高了施工效率。     

The First Template‐Free Growth of Crystalline Silicon Microtubes

A simple template‐free high‐temperature evaporation method was developed for the growth of crystalline Si microtubes for the first time. As‐grown Si microtubes were characterized using X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, and room‐temperature photoluminescence. The lengths of the Si tubes can reach several hundreds of micrometers; some of them have lengths on the order of millimeters. Each tube has a uniform outer diameter along its entire length, and the typical outer diameter is ≈ 2–3 μm. Most of the tubes have a wall thickness of ≈ 400–500 nm, though a considerable number of them exhibit a very thin wall thickness of ≈ 50 nm. Room‐temperature photoluminescence measurement shows the as‐synthesized Si microtubes have two strong emission peaks centered at ≈ 589 nm and ≈ 617 nm and a weak emission peak centered at ≈ 455 nm. A possible mechanism for the formation of these Si tubes is proposed. We believe that the present discovery of the crystalline Si microtubes will promote further experimental studies on their physical properties and smart applications.     

油品质量检验工作中应注意的十个问题

介绍了油品质检员做好油品检验工作在具体操作试验中应注意的十个问题，以确保试验数据真实有效，结论准确。