浅色补强填充剂LEE白滑粉在合成橡胶中的应用

介绍了新型浅色补强填充剂ＬＥＥ白滑粉的组成、物化性质、加工特性、硫化胶性能及应用前景。     

重馏分油加氢脱氮反应动力学模型的研究

简要地介绍了一些典型的模型氮化物的ＨＤＮ反应规律。根据胜利ＶＧＯ在３７２２Ｂ催化剂上的大量ＨＤＮ实验数据，提出了如下的ＨＤＮ基本反应动力学方程：ｄＣＮｄｔ＝－ｋ１＋Ｋ＊ＣＮＣＮＰＨ２为了扩大上式的应用范围，详细分析了各种因素（如原料油种类和馏程及Ｈ２Ｓ等）对ＨＤＮ的影响，并开发了相应的经验关联式，从而得到了一个较完整的馏分油ＨＤＮ反应动力学模型。验证实验表明，该模型是成功的。     

用于钻水平井的低密度水包油乳化钻井液

针对任平1井水平钻井的特点,研制了一种低密度、高油水比的水包油乳化钻井液。考察了乳化剂、增粘剂和配制工艺对乳状液性能的影响,评定了钻井液性能,介绍了现场应用情况。该钻井液性能稳定,润滑性好,净化井眼的能力强,能满足水平段钻井的要求。     

薄膜干涉型光学全通滤波器的设计与分析

设计并分析了用于多信道色谱补偿的薄膜Gires-Tournois干涉仪（GTI）型光学全通滤波（OAPF），讨论了反射镜的膜层结构对器件 的群延迟谱和反射谱的影响，。以及大角度入射引起的偏分离现象和幅度畸变现象，给出了单级和多级串拉OAPF的初步设计结果。     

水电建筑群的混凝土拆除

潘家口小水电群在建设中需要在原有建筑物上拆除混凝土，须克服场地窄小，交通不便、设备安全、环保问题等困难。采用了行之有效的静、动态爆破方案，成功地从５４个部位拆除钢筋混凝土１２００多立方米，从而保证了小水电群建设投产。     

分子振动态及其跃迁的激光相干控制

讨论了激光合成相干叠加态的原理及其性质 ,针对 XY2 型分子 ,证明了合成局域模振动的可行性 ,然后给出相干叠加态的跃迁几率特征 ,发现它仍表现出相干的特性 ,对之进行分析研究表明 ,分子的振动态具有可控性 ,态跃迁几率具有可控性。     

Successful pregnancies in the presence of spinal muscular atrophy: two case reports

We report two cases of successful pregnancy in women with chronic, infantile onset, or type II spinal muscular atrophy, both of whom delivered healthy, unaffected babies. The patients required concurrent management by a physiatrist, pulmonologist, and perinatologist throughout the pregnancy. Complications included recurrent urinary tract infections, dyspnea and worsening of pulmonary function, wheelchair seating and positioning problems, and musculoskeletal and low back pain. These problems resolved postpartum. One woman had vaginal delivery, the other had caesarean section, both of which were well-tolerated. Because of severe musculoskeletal deformity, pelvic assessment is necessary to determine the mode of delivery. The uterus has normal contractility and effective labor patterns can be established. Spinal/epidural anesthesia may be contraindicated because of spine deformity. The pregnancies had no deleterious effect on the progression of the disease in our patients, both of whom reported a positive experience with great personal fulfillment.     

An inhibitor of DNA topoisomerase I from Xenopus laevis ovaries

A novel, heat-resistant and Pronase-sensitive, inhibitor of eukaryotic DNA topoisomerase I has been purified from Xenopus laevis ovaries. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of the most purified fraction revealed three bands with apparent molecular masses of 25, 28.5, and 33.5 kDa. The 25- and 33.5-kDa peptides recovered from an SDS-PAGE gel inhibited X. laevis DNA topoisomerase I. The purified inhibitor was specific to DNA topoisomerase I and did not inhibit other DNA enzymes tested. The inhibitor blocked the catalytic activity of DNA topoisomerase I by interacting with the enzyme, rather than by competing for binding sites on substrate DNA. Binding of DNA topoisomerase I to substrate DNA was blocked by the inhibitor, as was the cleavage reaction catalyzed by DNA topoisomerase I. Inhibition of DNA topoisomerase I was relieved by divalent cations Ca2+, Mg2+, or Mn2+.     

Anti-inflammatory activity of myricetin-3-O-beta-D-glucuronide and related compounds

OBJECTIVE AND DESIGN: The anti-inflammatory effect of myricetinglucuronide (MGL) was investigated and structurally-related compounds were compared to examine the structure/activity-relationship in carrageenan-induced rat paw edema. MATERIALS AND SUBJECTS: In vitro studies were performed using rat basophilic leukemia (RBL-1) cells, human polymorphonuclear leukocytes (PMNL), COX-1 from ram seminal vesicle, COX-2 from sheep placenta and human venous blood. For the in vivo tests male Wistar rats were used, for the ex vivo test perfused rabbit ears. TREATMENT: 1-300 microg/kg MGL or myricetinmethylglucuronate and 0.1-5 mg/kg other related compounds administered p.o. (carrageenan edema). 5, 50 and 150 microg/kg MGL p.o. for 14 days (Freund's adjuvant arthritis), 5 and 50 microg/kg p.o. for 6 days (ulceration). METHODS: Anti-inflammatory effects were measured in carrageenan edema and in adjuvant arthritis. Incidence of gastric lesions was tested in an ulcerogenicity model in vivo. Influence on COX was determined in the perfused rabbit ear, in PMNL and in a test assay using COX-1 and COX-2. 5-LOX activity was studied using PMNL and RBL-1. The influence on platelet aggregation was evaluated measuring light transmission. RESULTS: MGL exerted a marked and dose-dependent anti-inflammatory effect in acute (carrageenan edema, ED50 15 microg/kg, indomethacin ED50 10 mg/kg) and chronic (adjuvant arthritis, inhibition at 150 microg/kg 18.1 % left paw, 20.6% right paw, indomethacin 3 mg/kg 18.0% and 19.4%)) models of inflammation. In the perfused rabbit ear 1 microg MGL inhibited the release of PGI2, PGD2 and PGE2 to the same extent as 1 microg indomethacin. The inhibition of COX-1 in the intact cell system was IC50 = 0.5 microM, that of indomethacin 0.0038 microM. In the isolated enzyme preparations of COX-1 and COX-2 the IC50 was 10 microM and 8 microM, that of indomethacin 9.2 mM and 2.4 microM. In the RBL-1 and PMNL test assay the inhibition of 5-LOX was 0.1 microM and 2.2 microM. An orally administered dose of 50 microg/kg/day induced no gastric ulcers in rats treated for 6 days. The investigations on carrageenan edema showed a close relationship between the structure of MGL and the anti-inflammatory effect. CONCLUSIONS: MGL is a COX-1, COX-2 and 5-LOX inhibitor. In view of the moderate in vitro activity and the very potent in vivo activity an additive mechanism must be involved. Small changes in the molecular structure lead to the loss or reduction of the anti-inflammatory activity.     

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当前我国管道天然气计量系以体积表示，就其计量器具而言，差压式流量计、容积式流量计和速变式流量计都有，但大流量计量大多仍采用标准孔板差压式流量计，其流量计量标准招待我国SY／T6143－1996《天然气流量的标准孔板计量方法》。文章介绍目前常用的三种流量计的优缺点比较；天然气标准孔板差压式流量计算机自动计量系统的检定，其中包括：标准孔板节流装置，静压、差压变送器、温度传感器、数据采集系统等组件的检定；以及计量器具的正确使用和维护。最后，文章指出目前流量计量的发展主要是二次仪表的发展，籍助应用计算机大大提高流量法的测量范围和准确度，但对用户来说，应选择性／价比合适的仪表，并要考虑所选用仪表要便于检定、维护，同时，计量检定部门则应跟上发展，为广大用户提供技术支持。