A decision support tool for the diagnosis of breast cancer based upon Fuzzy ARTMAP

This paper presents research into the application of the fuzzy ARTMAP neural network model to the diagnosis of cancer from fine-needle aspirates of the breast. Trained fuzzy ARTMAP networks are differently pruned so as to maximise accuracy, sensitivity and specificity. The differently pruned networks are then employed in a cascade of networks intended to separate cases into certain and suspicious classes. This mimics the predictive behaviour of a human pathologist. The fuzzy ARTMAP model also provides symbolic rule extraction facilities and the validity of the derived rules for this domain is discussed. Additionally, results are provided showing the effects upon network performance of different input features and different observers. The implications of the findings are discussed.     

CARVE-a constructive algorithm for real-valued examples

A constructive neural-network algorithm is presented. For any consistent classification task on real-valued training vectors, the algorithm constructs a feedforward network with a single hidden layer of threshold units which implements the task. The algorithm, which we call CARVE, extends the "sequential learning" algorithm of Marchand et al. (1990) from Boolean inputs to the real-valued input case, and uses convex hull methods for the determination of the network weights. The algorithm is an efficient training scheme for producing near-minimal network solutions for arbitrary classification tasks. The algorithm is applied to a number of benchmark problems including German and Sejnowski's sonar data, the Monks problems and Fisher's iris data. A significant application of the constructive algorithm is in providing an initial network topology and initial weights for other neural-network training schemes, and this is demonstrated by application to backpropagation.     

Closed-loop drip irrigation control using a hybrid wireless sensor and actuator network

In this research, a closed-loop drip irrigation control hybrid wireless sensor and actuator network (HWSAN) prototype were developed and deployed in a crop field for soil property precise measurement and precision irrigation in accordance with the measured soil property. The HWSAN was composed of a wireless sensor and actuator network (WSAN) used for in-field soil property monitoring and irrigation control and a laboratory supervising system. The WSAN included ten sensor nodes, five irrigation control nodes...     

Physics-Based Person Tracking Using the Anthropomorphic Walker

We introduce a physics-based model for 3D person tracking. Based on a biomechanical characterization of lower-body dynamics, the model captures important physical properties of bipedal locomotion such as balance and ground contact. The model generalizes naturally to variations in style due to changes in speed, step-length, and mass, and avoids common problems (such as footskate) that arise with existing trackers. The dynamics comprise a two degree-of-freedom representation of human locomotion with inelastic ground contact. A stochastic controller generates impulsive forces during the toe-off stage of walking, and spring-like forces between the legs. A higher-dimensional kinematic body model is conditioned on the underlying dynamics. The combined model is used to track walking people in video, including examples with turning, occlusion, and varying gait. We also report quantitative monocular and binocular tracking results with the HumanEva dataset.     

Action selection and task sequence learning for hybrid dynamical cognitive agents

As a foundation for action selection and task-sequencing intelligence, the reactive and deliberative subsystems of a hybrid agent can be unified by a single, shared representation of intention. In this paper, we summarize a framework for hybrid dynamical cognitive agents (HDCAs) that incorporates a representation of dynamical intention into both reactive and deliberative structures of a hybrid dynamical system model, and we present methods for learning in these intention-guided agents. The HDCA framework is based on ideas from spreading activation models and belief–desire–intention (BDI) models. Intentions and other cognitive elements are represented as interconnected, continuously varying quantities, employed by both reactive and deliberative processes. HDCA learning methods—such as Hebbian strengthening of links between co-active elements, and belief–intention learning of task-specific relationships—modify interconnections among cognitive elements, extending the benefits of reactive intelligence by enhancing high-level task sequencing without additional reliance on or modification of deliberation. We also present demonstrations of simulated robots that learned geographic and domain-specific task relationships in an office environment.     

A rapid computational filter for predicting the rate of human renal clearance

In silico models that predict the rate of human renal clearance for a diverse set of drugs, that exhibit both active secretion and net re-absorption, have been produced using three statistical approaches. Partial Least Squares (PLS) and Random Forests (RF) have been used to produce continuous models whereas Classification And Regression Trees (CART) has only been used for a classification model. The best models generated from either PLS or RF produce significant models that can predict acids/zwitterions, bases and neutrals with approximate average fold errors of 3, 3 and 4, respectively, for an independent test set that covers oral drug-like property space. These models contain additional information on top of any influence arising from plasma protein binding on the rate of renal clearance. Classification And Regression Trees (CART) has been used to generate a classification tree leading to a simple set of Renal Clearance Rules (RCR) that can be applied to man. The rules are influenced by lipophilicity and ion class and can correctly predict 60% of an independent test set. These percentages increase to 71% and 79% for drugs with renal clearances of < 0.1 ml/min/kg and > 1 ml/min/kg, respectively. As far as the authors are aware these are the first set of models to appear in the literature that predict the rate of human renal clearance and can be used to manipulate molecular properties leading to new drugs that are less likely to fail due to renal clearance.     

Tactical combat movements: inter-individual variation in performance due to the effects of load carriage

An examination into the effects of carried military equipment on the performance of two tactical combat movement simulations was conducted. Nineteen Airfield Defence Guards performed a break contact (five 30-m sprints) and a fire and movement simulation (16 6-m bounds) in five load conditions (10–30 kg). Heavier loads significantly increased movement duration on the break contact (0.8%/kg load) and fire and movement (1.1%/kg). Performance deterioration was observed from the beginning to the end of the series of movements (bounds or sprints) with deterioration becoming significantly greater in heavier load conditions. Inter-individual variation between slower and faster participants showed a range in load effects; 0.6, 0.8%/kg for fast and 1.0, 1.4%/kg for slow (break contact, fire and movement, respectively). Velocity profiles revealed that the initial acceleration and peak velocity were the primary determinants of performance. As the duration of these tactical combat movements reflects periods of heightened vulnerability, these findings highlight important implications for commanders.

Practitioner Summary: Increasing amounts of carried military equipment impairs the performance of tactical combat movements. Examination of inter-individual variation in velocity profiles identified that the initial acceleration and the peak velocity achieved during sprints and bounds are key determinants of overall performance.     

Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts

Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantify the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation period). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.     

Modeling the glucose regulatory system in extreme preterm infants

Background

Premature infants represent a significant proportion of the neonatal intensive care population. Blood glucose homeostasis in this group is often disturbed by immaturity of endogenous regulatory systems and the stress of their condition. Hypo- and hyperglycemia are frequently reported in very low birth weight infants, and more mature infants often experience low levels of glycemia. A model capturing the unique fundamental dynamics of the neonatal glucose regulatory system could be used to develop better blood glucose control methods.

Methods

A metabolic system model is adapted from adult critical care to the unique physiological case of the neonate. Integral-based fitting methods were used to identify time-varying insulin sensitivity and non-insulin mediated glucose uptake profiles. The clinically important predictive ability of the model was assessed by assuming insulin sensitivity was constant over prediction intervals of 1, 2 and 4 h forward and comparing model-simulated versus actual clinical glucose values for all recorded interventions. The clinical data included 1091 glucose measurements over 3567 total patient hours, along with all associated insulin and nutritional infusion data, for N = 25 total cases. Ethics approval was obtained from the Upper South A Regional Ethics Committee for this study.

Results

The identified model had a median absolute percentage error of 2.4% [IQR: 0.9-4.8%] between model-fitted and clinical glucose values. Median absolute prediction errors at 1-, 2- and 4-h intervals were 5.2% [IQR: 2.5-10.3%], 9.4% [IQR: 4.5-18.4%] and 13.6% [IQR: 6.3-27.6%] respectively.

Conclusions

The model accurately captures and predicts the fundamental dynamic behaviors of the neonatal metabolism well enough for effective clinical decision support in glycemic control. The adaptation from adult to a neonatal case is based on the data from the literature. Low prediction errors and very low fitting errors indicate that the fundamental dynamics of glucose metabolism in both premature neonates and critical care adults can be described by similar mathematical models.     

Fast Lighting Independent Background Subtraction

This paper describes a simple method of fast background subtraction based upon disparity verification that is invariant to arbitrarily rapid run-time changes in illumination. Using two or more cameras, the method requires the off-line construction of disparity fields mapping the primary background images. At runtime, segmentation is performed by checking background image to each of the additional auxiliary color intensity values at corresponding pixels. If more than two cameras are available, more robust segmentation can be achieved and, in particular, the occlusion shadows can be generally eliminated as well. Because the method only assumes fixed background geometry, the technique allows for illumination variation at runtime. Since no disparity search is performed, the algorithm is easily implemented in real-time on conventional hardware.