全文获取类型
收费全文 | 141篇 |
免费 | 0篇 |
专业分类
电工技术 | 2篇 |
化学工业 | 17篇 |
金属工艺 | 2篇 |
机械仪表 | 1篇 |
建筑科学 | 4篇 |
能源动力 | 4篇 |
轻工业 | 4篇 |
无线电 | 11篇 |
一般工业技术 | 77篇 |
冶金工业 | 9篇 |
自动化技术 | 10篇 |
出版年
2023年 | 1篇 |
2022年 | 10篇 |
2021年 | 4篇 |
2020年 | 2篇 |
2019年 | 2篇 |
2018年 | 9篇 |
2017年 | 7篇 |
2016年 | 13篇 |
2015年 | 10篇 |
2014年 | 21篇 |
2013年 | 16篇 |
2012年 | 15篇 |
2011年 | 9篇 |
2010年 | 3篇 |
2009年 | 2篇 |
2008年 | 2篇 |
2007年 | 1篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2003年 | 1篇 |
2002年 | 1篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1998年 | 3篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1988年 | 1篇 |
1986年 | 1篇 |
排序方式: 共有141条查询结果,搜索用时 15 毫秒
141.
Hanan Ehtewish Abdelilah Arredouani Omar El-Agnaf 《International journal of molecular sciences》2022,23(11)
Cognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer’s disease (AD), and other forms of dementia are recognized as common comorbidities of type 2 diabetes mellitus (T2DM). Currently, there are no disease-modifying therapies or definitive clinical diagnostic and prognostic tools for dementia, and the mechanisms underpinning the link between T2DM and cognitive dysfunction remain equivocal. Some of the suggested pathophysiological mechanisms underlying cognitive decline in diabetes patients include hyperglycemia, insulin resistance and altered insulin signaling, neuroinflammation, cerebral microvascular injury, and buildup of cerebral amyloid and tau proteins. Given the skyrocketing global rates of diabetes and neurodegenerative disorders, there is an urgent need to discover novel biomarkers relevant to the co-morbidity of both conditions to guide future diagnostic approaches. This review aims to provide a comprehensive background of the potential risk factors, the identified biomarkers of diabetes-related cognitive decrements, and the underlying processes of diabetes-associated cognitive dysfunction. Aging, poor glycemic control, hypoglycemia and hyperglycemic episodes, depression, and vascular complications are associated with increased risk of dementia. Conclusive research studies that have attempted to find specific biomarkers are limited. However, the most frequent considerations in such investigations are related to C reactive protein, tau protein, brain-derived neurotrophic factor, advanced glycation end products, glycosylated hemoglobin, and adipokines. 相似文献