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61.
In this paper we propose an adaptation of the Eikonal equation on weighted graphs, using the framework of Partial difference Equations, and with the motivation of extending this equation’s applications to any discrete data that can be represented by graphs. This adaptation leads to a finite difference equation defined on weighted graphs and a new efficient algorithm for multiple labels simultaneous propagation on graphs, based on such equation. We will show that such approach enables the resolution of many applications in image and high dimensional data processing using a unique framework.  相似文献   
62.
The windowless target electron beam experimental irradiation (WEBEXPIR) program was set-up as part of the MYRRHA/XT-ADS R&D effort on the spallation target design to investigate the interaction of a proton beam with a liquid lead-bismuth eutectic (LBE) free surface. In particular, possible free surface distortion or shockwave effects in nominal conditions and during sudden beam on/off transient situations, as well as possible enhanced evaporation were assessed. An experiment was conceived at the IBA TT-1000 Rhodotron, where a 7 MeV electron beam was used to simulate the high power deposition at the MYRRHA/XT-ADS LBE free surface. The geometry and the LBE flow characteristics in the WEBEXPIR set-up were made as representative as possible of the actual situation in the MYRRHA/XT-ADS spallation target. Irradiation experiments were carried out at beam currents of up to 10 mA, corresponding to 40 times the nominal beam current necessary to reproduce the MYRRHA/XT-ADS conditions. Preliminary analyses show that the WEBEXPIR free surface flow was not disturbed by the interaction with the electron beam and that vacuum conditions stayed well within the design specifications.  相似文献   
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  总被引:1,自引:0,他引:1  
The aim of the work presented in this paper is to improve the off-line programming capability of industrial robots by improving their accuracy. Rather than impose more strict manufacturing tolerances, it is widely accepted that a method of identifying kinematic parameters specific to each individual robot provides a cost effective way of improving accuracy. A procedure is presented for identification of actual kinematic parameters, which uses the plane of rotation and centre of rotation introduced by Stone. The procedure differs from that of Stone in that it makes use of the radius of rotation and also introduces a translation of the plane of rotation along the axis of rotation. This allows for the direct identification of the D–H model parameters which are more widely accepted and easier to interpret than the S model parameters. It is shown that, unlike the original method of Stone, the new procedure can also deal with the situation when two consecutive joint axes are parallel. The method is validated on both simulated data and real measured data for a Puma 560 robot, showing an improvement in positioning accuracy of around 80%.  相似文献   
65.
Ellipsometry was used as a technique to determine glass temperature transitions of homopolymer thin films of polystyrene and poly(methyl methacrylate) ranging from 5 to 200 nm. The technique operated systematically at various energies reveals the presence of multiple transitions in these films under certain conditions of preparation. It was observed that in the case of strong polymer-substrate interactions, several Tg were measured and ascribed to a layered structure in the film. In the absence of strong interactions, a more uniform film presenting a single Tg was observed no matter the thickness. The results confirm the recent assumption of thin films organised in multilayers and emphasize the importance of using a highly sensitive multi-wavelength technique in probing such properties.  相似文献   
66.
Multimedia Tools and Applications - In this paper, a novel dynamic color image watermarking based on discrete wavelet transform (DWT) and singular value decomposition (SVD) is proposed. The...  相似文献   
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Chondrosarcomas are malignant bone tumors. Their abundant cartilage-like extracellular matrix and their hypoxic microenvironment contribute to their resistance to chemotherapy and radiotherapy, and no effective therapy is currently available. MicroRNAs (miRNAs) may be an interesting alternative in the development of therapeutic options. Here, for the first time in chondrosarcoma cells, we carried out high-throughput functional screening using impedancemetry, and identified five miRNAs with potential antiproliferative or chemosensitive effects on SW1353 chondrosarcoma cells. The cytotoxic effects of miR-342-5p and miR-491-5p were confirmed on three chondrosarcoma cell lines, using functional validation under normoxia and hypoxia. Both miRNAs induced apoptosis and miR-342-5p also induced autophagy. Western blots and luciferase reporter assays identified for the first time Bcl-2 as a direct target of miR-342-5p, and also Bcl-xL as a direct target of both miR-342-5p and miR-491-5p in chondrosarcoma cells. MiR-491-5p also inhibited EGFR expression. Finally, only miR-342-5p induced cell death on a relevant 3D chondrosarcoma organoid model under hypoxia that mimics the in vivo microenvironment. Altogether, our results revealed the tumor suppressive activity of miR-342-5p, and to a lesser extent of miR-491-5p, on chondrosarcoma lines. Through this study, we also confirmed the potential of Bcl-2 family members as therapeutic targets in chondrosarcomas.  相似文献   
69.
    
Using a modified RNA-sequencing (RNA-seq) approach, we discovered a new family of unusually short RNAs mapping to ribosomal RNA 5.8S, which we named dodecaRNAs (doRNAs), according to the number of core nucleotides (12 nt) their members contain. Using a new quantitative detection method that we developed, we confirmed our RNA-seq data and determined that the minimal core doRNA sequence and its 13-nt variant C-doRNA (doRNA with a 5′ Cytosine) are the two most abundant doRNAs, which, together, may outnumber microRNAs. The C-doRNA/doRNA ratio is stable within species but differed between species. doRNA and C-doRNA are mainly cytoplasmic and interact with heterogeneous nuclear ribonucleoproteins (hnRNP) A0, A1 and A2B1, but not Argonaute 2. Reporter gene activity assays suggest that C-doRNA may function as a regulator of Annexin II receptor (AXIIR) expression. doRNAs are differentially expressed in prostate cancer cells/tissues and may control cell migration. These findings suggest that unusually short RNAs may be more abundant and important than previously thought.  相似文献   
70.
    
The ultimate performance of a solid state device is limited by the restricted number of crystalline substrates that are available for epitaxial growth. As a result, only a small fraction of semiconductors are usable. This study describes a novel concept for a tunable compliant substrate for epitaxy, based on a graphene–porous silicon nanocomposite, which extends the range of available lattice constants for epitaxial semiconductor alloys. The presence of graphene and its effect on the strain of the porous layer lattice parameter are discussed in detail and new remarkable properties are demonstrated. These include thermal stability up to 900 °C, lattice tuning up to 0.9 % mismatch, and compliance under stress for virtual substrate thicknesses of several micrometers. A theoretical model is proposed to define the compliant substrate design rules. These advances lay the foundation for the fabrication of a compliant substrate that could unlock the lattice constant restrictions for defect‐free new epitaxial semiconductor alloys and devices.  相似文献   
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