16MnR钢高压除氧器焊接接头裂纹的成因

本文采用电镜，Ｘ射线衍射分析、裂纹扩展速率ｄａ／ｄＮ及门槛值△Ｋｔｈ试验，研究了火力发电厂１６ＭｎＲ钢高压除氧器焊接接头裂纹的形成原因，结果表明，原发裂纹为延迟裂纹，运行工况下，裂纹以应力腐蚀裂纹方式扩展。     

离子氮化对镀铬层组织与性能的影响

研究了镀铬层经离子氮化后的组织和性能。分别用SEM、电子探针和X光衍射仪观察和分析了复合处理层剖面的组织、结构和成分,试验结果表明:离子氮化能使镀铬层的网状裂纹弥合,可明显提高了镀层表面硬度、结合力和耐蚀性。     

燃烧合成三元碳化合物Ti2AlC1-x

采用Ti，Al和C元素粉末为反应物原料，通过燃烧合成法首次成功地制备出了单相三元碳化合物Ti2AlC1-x。实验结果表明：若以“理想”晶体结构化学式Ti2AlC化学计量比为起始反应原料配比，燃烧产物主晶相为Ti2AlC2；以缺碳的非化学计量比(Ti2AlC1-x)为反应原料配比，即Ti：Al：C=3：1．5：1=2：1：0．7(摩尔比)，得到单相的燃烧产物Ti2AlC1-x。从热力学原理的角度探讨了不同原料摩尔配比对燃烧产物相组成的影响机理。     

NH4F及燃烧温度对燃烧合成长柱状Yb α-Sialon粉体的影响

采用SHS法合成了Yb α-Sialon粉体，采用XRD和SEM分析和研究了添加剂NH4F及燃烧温度对燃烧合成长柱状Yb α-Sialon相组成和形貌的影响。实验发现，在不同条件下，添加剂NH4F对燃烧合成长柱状α-Sialon的晶体形貌可以起到抑制和促进两个相反的作用。温度越高，晶体生长速率越大，反应降温越慢，晶体生长时间越长，长柱状晶体生长越完整。燃烧合成得到的长柱状α-Sialon粉体，在室温下，以酒精为介质经过30min以上的超声分散，可以达到较好的分散效果。     

基于Web services的WebGISVisA体系结构研究与实现*

针对目前网络地理信息系统体系结构难以实现Internet环境下的异构空间信息的互操作问题,深入分析其主要原因,在对现有网络地理信息系统的三层体系结构进行深入分析的基础上,提出一种基于Web services的网络地理信息系统体系结构(Web-based geographical information services visualization architecture,WebGISVisA).WebGISVisA体系结构通过Web services对各个地理信息系统组件进行包装,实现各个组件的跨平台操作,从技术上使得客户端和服务端达到了负载平衡,完成了WebGIS三维的虚拟现实,实现了在Internet下空间数据互操作和跨平台的功能,最大限度地达到数据共享.     

基于细观建模的堆石混凝土抗压试验的数值模拟

从细观结构的角度出发,将堆石混凝土视为堆石体与自密实混凝土组合形成的复合材料,利用MATLAB与ANSYS/LS-DYNA软件建立了三维有限元模型,然后在此基础上进行了堆石混凝土模型抗压试验的数值模拟.探讨分析了应变率和堆石与混凝土粘结强度对堆石混凝土的抗压强度的影响.结果表明:堆石混凝土的抗压强度随着应变率的增大而增大,且随着粘结强度的增大而增大,但是堆石混凝土对应变率的敏感性较高,对粘结强度的敏感性较低.     

Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro

Negatively charged fluorescent carbon dots (CDs, E_m=608 nm) were hydrothermally prepared from thiophene phenylpropionic acid polymers and then successfully loaded with the positively charged anticancer cargo coptisine, which suffers from poor bioavailability. The formed CD-coptisine complexes were thoroughly characterized by particle size, morphology, drug loading efficiency, drug release, cellular uptake and cellular toxicity in vitro and antitumor activities in vivo. In this nano-carrier system, red emissive CDs possess multiple advantages as follows: 1) high drug loading efficiency (>96 %); 2) sustained drug release; 3) enhanced drug efficacy towards cancer cells; 4) EPR effect; 5) drug release tracing with near-infrared imaging. These properties indicated that red emissive CDs prepared from polymers could be used as a novel drug delivery system with integrated therapeutic and imaging functions in cancer therapy, which are expected to have great potential in future clinical applications.     

Design,Synthesis and Biological Evaluation of Steroidal Glycoconjugates as Potential Antiproliferative Agents

To systematically evaluate the impact of neoglycosylation upon the anticancer activities and selectivity of steroids, four series of neoglycosides of diosgenin, pregnenolone, dehydroepiandrosterone and estrone were designed and synthesized according to the neoglycosylation approach. The structures of all the products were elucidated by NMR analysis, and the stereochemistry of C20-MeON-pregnenolone was confirmed by crystal X-ray diffraction. The compounds′ cytotoxicity on five human cancer cell lines was evaluated using a Cell Counting Kit-8 assay, and structure–activity relationships (SAR) are discussed. 2-deoxy-d -glucoside 5 k displayed the most potent antiproliferative activities against HepG2 cells with an IC₅₀ value of 1.5 μM. Further pharmacological experiments on compound 5 k on HepG2 cells revealed that it could cause morphological changes and cell-cycle arrest at the G0/G1 phase and then induced the apoptosis, which might be associated with the enhanced expression of high-mobility group Box 1 (HMGB1). Taken together, these findings prove that the neoglycosylation of steroids could be a promising strategy for the discovery of potential antiproliferative agents.     

抗高温高密度油基钻井液体系研究及性能评价

为满足高温高压深层油气资源勘探开发的需求,通过处理剂的优选,研制了一套抗高温高密度油基钻井液体系,并在室内对其综合性能进行了评价.结果表明:该油基钻井液体系具有良好的抗高温性能,经过200℃老化后,钻井液体系的流变性能稳定,高温高压滤失量小于5 mL,破乳电压值可以达到1000 V以上;体系具有良好的沉降稳定性能,经过高温老化后上下密度差较小,未发生明显沉降;体系具有良好的抑制性能,能使目标区块储层段岩屑的滚动回收率达到98％以上;在油基钻井液体系中加入淡水、NaCl和岩屑后,体系的流变性能、破乳电压和高温高压滤失量变化均不大,说明该钻井液体系具有良好的抗污染性能;该油基钻井液体系具有较好的储层保护效果,天然岩心使用钻井液污染后,渗透率恢复值仍能大于90％.     

青海镁产业专利导航发展分析

通过对盐湖提镁技术与镁合金等重点技术的专利分析,得到全球镁产业链不同环节的技术优势国家;从镁合金的专利权人排名来看,日本和韩国的企业展现出优势;基于专利权人的分析,挖掘中国镁技术领域的主要研究团队等重要情报信息;通过对中国及青海镁产业的专利布局分析,确定中国镁产业技术优势省、相关研发机构,总结青海省在镁产业领域的当前水平与可能的突破点,对镁产业关键技术进行导航探究,深度剖析镁产业研究价值与发展空间。同时对青海盐湖产业发展的优劣势条件进行分析,提出青海镁产业未来发展应该结合本地特色增加专利申请量,综合开发利用资源,提升关键技术,加强人才引进,促进产学研深度融合等发展建议。