Increased prolactin and thyrotrophin secretion following oral metoclopramide: dose-response relationships

In pregnant female rat, oxygen tension was measured in vivo with an oxygen microelectrode and the following statistically significant data (Student's test) were obtained: -- not significant variability in four groups of six control rats; -- highly significant decrease of oxygen tension twenty-four hours after biovariectomy in four groups of six operated rats; -- in twelve operated and treated by substitutive hormonotherapy rats, pO2 was at the same level than in control rats; -- in eighteen operated rats, the oxygen tension measured after embryonic death was identical to control rats. These experiments clearly demonstrate twenty four hours after biovariectomy a decreased oxygen tension. Simultaneously to this decrease, a diminution of uterine blood flow takes place. This pO2 diminution should be dependent on decrease of ovarian hormones since the substitutive hormonotherapy prevents its appearance. A good explanation of this phenomenon is the high requirement of hypoxic embryo for oxygen; moreover after the embryonic death, the intra-uterine pO2 increases.     

Computer vision for human modelling and analysis

This report summarises the author's views and experience on the application of computer vision technology for the modelling and analysis of people. The author conducted research which led to the first commercial booth system for capturing animated models of people for applications in games, multimedia and virtual reality. This research is ongoing with the aim of developing studio capture technology to enable photo-realistic capture of a person's shape, appearance and movement for broadcast production.Published online: 8 August 2003     

Ischemic modulation of vulnerable period and the effects of pharmacological treatment of ischemia-induced arrhythmias: a simulation study

First identified in the 1930s (Ferris et al., 1936 and Wiggers and Wegria, 1939), the concept of vulnerability applies perfectly to biological oscillators. We can safely say that vulnerability is an inherent property of any excitable media. The duration of vulnerable period (VP) (the time interval during which single stimuli can initiate self-sustaining propagation) is sensitive to medium properties and stimulus parameters (stimulus field, timing behind the conditioning wave, and stimulus amplitude). Apart from medium properties and stimulus characteristics, heart vulnerability is affected by any intervention targeting the excitatory and recovery process. Therefore, we can expect that any pathological condition disturbing heart excitation or tissue recovery will most probably alter the duration of VP. In this paper, we shall explore the implications of ischemia and one of the arrhythmia counteracting methods widely used in clinical practice-antiarrhythmic drugs--in changing the boundaries of VP. The Cardiac Arrhythmia Suppression Trial (CAST) studies, as well as classification based on functional characteristics, revealed the arrhythmogenic potential of both Class I and Class III agents, but failed to identify the proarrhythmic mechanisms. This study presents results from a mathematical model (Cimponeriu et al., 2001) of the ventricle based on Luo-Rudy cellular formulation Luo and Rudy, 1991) modified for studying the ischemic modulation of VP and the effects of pharmacological treatment of ischemia-induced arrhythmia. Simulations revealed the link between the cellular antiarrhythmic properties and the proarrhythmic effect at the multicellular level in the case of Na+ channel blockade. Na+ channel blockade delayed recovery of cellular excitability, but also introduced a nonuniform dispersion of refractoriness along the cardiac fiber that can serve as a substrate for initiating a new arrhythmia. Our initial analysis proved that fast unbinding rates are essential in reducing the proarrhythmic potential of Class I drugs. However, further investigations led us to believe that binding properties are equally important. An antiarrhythmic drug with high affinity for drug-channel complex formation elicits a higher level of blockade per time unit. Under this light, we hypothesize that even the modern, fast unbinding drugs are not necessarily safe.     

Development of matrix patches for transdermal delivery of a highly lipophilic antiestrogen

The aim of this study was to develop matrix-type transdermal systems (TDSs) containing the highly lipophilic (log P = 5.82) antiestrogen (AE) and the permeation enhancers propylene glycol and lauric acid. For that purpose, permeation of AE from various adhesive matrices through excised skin of hairless mice was evaluated. It was found that pretreatment of the skin with permeation enhancers raised the transdermal flux of subsequently applied antiestrogen. Highest steady-state transdermal fluxes (1.1 µg cm^-2 h^-1) were obtained from Gelva®, polyacrylate adhesive, followed by 0.55 µg cm^-2 h^-1 from Oppanol® polyisobutylene, 0.31 µg cm^-2 h^-1 from BIO-PSA® silicone, and 0.12 µg cm^-2 h^-1 from Sekisui polyacrylate matrices. In order to develop TDS with high content of fluid permeation enhancer propylene glycol, two different strategies were investigated. One strategy was the addition of hydroxypropyl cellulose (HPC) as thickening agent to Gelva matrices. This allowed for propylene glycol loading levels of up to 30%, resulting in transdermal AE fluxes of 0.09 µg cm^-2 h^-1. On the other hand, a fleece-laminated backing foil was loaded with the described permeation enhancer formulation and laminated with polyacrylate adhesive layer, resulting in transdermal AE fluxes of 0.06 µg cm^-2 h^-1. However, application of these TDSs on skin pretreated with permeation enhancers raised the fluxes to 2.6 µg cm^-2 h^-1 from Gelva/HPC and 0.46 µg cm^-2 h^-1 from fleece/Sekisui.     

Monolithically Fabricated Microgripper With Integrated Force Sensor for Manipulating Microobjects and Biological Cells Aligned in an Ultrasonic Field

This paper reports an electrostatic microelectromechanical systems (MEMS) gripper with an integrated capacitive force sensor. The sensitivity is more than three orders of magnitude higher than other monolithically fabricated MEMS grippers with force feedback. This force sensing resolution provides feedback in the range of the forces that dominate the micromanipulation process. A MEMS ultrasonic device is described for aligning microobjects suspended in water using ultrasonic fields. The alignment of the particles is of a sufficient accuracy that the microgripper must only return to a fixed position in order to pick up particles less than 100 mum in diameter. The concept is also demonstrated with HeLa cells, thus providing a useful tool in biological research and cell assays     

The Role of 3-D Sound in Human Reaction and Performance in Augmented Reality Environments

Three-dimensional sound's effectiveness in virtual reality (VR) environments has been widely studied. However, due to the big differences between VR and augmented reality (AR) systems in registration, calibration, perceptual difference of immersiveness, navigation, and localization, it is important to develop new approaches to seamlessly register virtual 3-D sound in AR environments and conduct studies on 3-D sound's effectiveness in AR context. In this paper, we design two experimental AR environments to study the effectiveness of 3-D sound both quantitatively and qualitatively. Two different tracking methods are applied to retrieve the 3-D position of virtual sound sources in each experiment. We examine the impacts of 3-D sound on improving depth perception and shortening task completion time. We also investigate its impacts on immersive and realistic perception, different spatial objects identification, and subjective feeling of "human presence and collaboration". Our studies show that applying 3-D sound is an effective way to complement visual AR environments. It helps depth perception and task performance, and facilitates collaborations between users. Moreover, it enables a more realistic environment and more immersive feeling of being inside the AR environment by both visual and auditory means. In order to make full use of the intensity cues provided by 3-D sound, a process to scale the intensity difference of 3-D sound at different depths is designed to cater small AR environments. The user study results show that the scaled 3-D sound significantly increases the accuracy of depth judgments and shortens the searching task completion time. This method provides a necessary foundation for implementing 3-D sound in small AR environments. Our user study results also show that this process does not degrade the intuitiveness and realism of an augmented audio reality environment     

Genetic and environmental bases of childhood antisocial behavior: A multi-informant twin study.

Genetic and environmental influences on childhood antisocial and aggressive behavior (ASB) during childhood were examined in 9- to 10-year-old twins, using a multi-informant approach. The sample (605 families of twins or triplets) was socioeconomically and ethnically diverse, representative of the culturally diverse urban population in Southern California. Measures of ASB included symptom counts for conduct disorder, ratings of aggression, delinquency, and psychopathic traits obtained through child self-reports, teacher, and caregiver ratings. Multivariate analysis revealed a common ASB factor across informants that was strongly heritable (heritability was .96), highlighting the importance of a broad, general measure obtained from multiple sources as a plausible construct for future investigations of specific genetic mechanisms in ASB. The best fitting multivariate model required informant-specific genetic, environmental, and rater effects for variation in observed ASB measures. The results suggest that parents, children, and teachers have only a partly "shared view" and that the additional factors that influence the "rater-specific" view of the child's antisocial behavior vary for different informants. This is the first study to demonstrate strong heritable effects on ASB in ethnically and economically diverse samples. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Impact of scale on the effectiveness of disease control strategies for epidemics with cryptic infection in a dynamical landscape: an example for a crop disease.

We use a spatially explicit, stochastic model to analyse the effectiveness of different scales of local control strategies in containing the long-term, multi-seasonal spread of a crop disease through a dynamically changing population of susceptible crops in which there is cryptic infection. The model distinguishes between susceptible, infested and symptomatic fields. It is motivated by rhizomania disease on sugar beet in the UK as an exemplar of a spatially structured and partially asymptomatic epidemic. Our results show the importance of matching the scales of local control strategies to prevent intensification and regional spread of disease with the inherent temporal and spatial scales of an epidemic. A simple field-scale containment strategy, whereby the susceptible crop is no longer grown on fields showing symptoms, fails for this system with cryptic infection because the locally applied control lags behind the epidemic. A farm-scale strategy, whereby growers respond to the disease status of neighbouring farms by transferring their quota for sugar beet to farmers in regions of reduced risk, succeeds. We conclude that a soil-borne pathogen such as rhizomania could be managed by movement of susceptible crops in the landscape using a strategy that matches the temporal and spatial scales of the epidemic and which take account of risk aversion among growers. We show some parallels and differences in effectiveness between a 'culling' strategy involving crop removal around emerging foci and the local deployment of partially resistant varieties that reduce amplification and transmission of inoculum. Some relationships between the control of plant and livestock diseases are briefly discussed.     

High Sensitivity,Wearable, Piezoresistive Pressure Sensors Based on Irregular Microhump Structures and Its Applications in Body Motion Sensing

A pressure sensor based on irregular microhump patterns has been proposed and developed. The devices show high sensitivity and broad operating pressure regime while comparing with regular micropattern devices. Finite element analysis (FEA) is utilized to confirm the sensing mechanism and predict the performance of the pressure sensor based on the microhump structures. Silicon carbide sandpaper is employed as the mold to develop polydimethylsiloxane (PDMS) microhump patterns with various sizes. The active layer of the piezoresistive pressure sensor is developed by spin coating PEDOT:PSS on top of the patterned PDMS. The devices show an averaged sensitivity as high as 851 kPa^?1, broad operating pressure range (20 kPa), low operating power (100 nW), and fast response speed (6.7 kHz). Owing to their flexible properties, the devices are applied to human body motion sensing and radial artery pulse. These flexible high sensitivity devices show great potential in the next generation of smart sensors for robotics, real‐time health monitoring, and biomedical applications.     

3D Scene Reconstruction from Multiple Spherical Stereo Pairs

We propose a 3D environment modelling method using multiple pairs of high-resolution spherical images. Spherical images of a scene are captured using a rotating line scan camera. Reconstruction is based on stereo image pairs with a vertical displacement between camera views. A 3D mesh model for each pair of spherical images is reconstructed by stereo matching. For accurate surface reconstruction, we propose a PDE-based disparity estimation method which produces continuous depth fields with sharp depth discontinuities even in occluded and highly textured regions. A full environment model is constructed by fusion of partial reconstruction from spherical stereo pairs at multiple widely spaced locations. To avoid camera calibration steps for all camera locations, we calculate 3D rigid transforms between capture points using feature matching and register all meshes into a unified coordinate system. Finally a complete 3D model of the environment is generated by selecting the most reliable observations among overlapped surface measurements considering surface visibility, orientation and distance from the camera. We analyse the characteristics and behaviour of errors for spherical stereo imaging. Performance of the proposed algorithm is evaluated against ground-truth from the Middlebury stereo test bed and LIDAR scans. Results are also compared with conventional structure-from-motion algorithms. The final composite model is rendered from a wide range of viewpoints with high quality textures.