Combined chemotherapy with 5-FU+cis-platin or UFT+cisplatin

The historical background, pharmacological effects, significance as modulation therapy and clinical results of chemotherapy combining 5-FU/cisplatin or UFT/cisplatin based on the concept of biochemical modulation are introduced and reviewed. The evident significance of this method among various chemotherapies are its stable maintenance of the effective concentration of 5-FU and the outstanding anticancer efficacy at the clinical level. However, an optimal administration method has not necessarily been established to date. The concentrations and duration of anticancer effects and side effects for each drug remain to be studied. By resolving these problems, this optimal administration method (both the route and duration) may be clarified. Anything compromising patient quality of life, of course, must be prevented. The above gives the basis of our recent experience. We considered it an effective combination therapy and expect that numerous trials at various centers will lead to improvements.     

Association of interleukin 6 release from endothelial cells and pulmonary hypertension in SLE

OBJECTIVE: To investigate how sera from 37 patients with systemic lupus erythematosus (SLE) stimulate interleukin (IL) 6 release from IL-1beta pretreated endothelial cells and compare these effects to those of sera from 16 normal controls. METHODS: Endothelial cells pretreated 18 h with IL-1beta (5 U/ml) were incubated 2 h with sera diluted 10-fold with phosphate buffered saline (PBS). IL-6 concentrations in endothelial culture supernatants collected after incubation were measured by ELISA. RESULTS: Compared with PBS, sera from controls and 24 patients with SLE suppressed IL-6 release from IL-1beta pretreated cells. However, sera from 13 patients with SLE augmented IL-6 release. Of note, sera from 5 patients with pulmonary hypertension induced the highest level of IL-6 release. IgG from control sera suppressed IL-6 release, whereas F(ab')2 did not. Both IgG and F(ab')2 from the sera of patients with SLE with pulmonary hypertension augmented IL-6 release from IL-1beta pretreated cells. CONCLUSION: IgG antiendothelial cell antibodies from patients with SLE may be associated with the pathogenesis of SLE and pulmonary hypertension.     

Analysis of close-contact melting for octadecane and ice inside isothermally heated horizontal rectangular capsule

Close-contact melting characteristics of phase change materials (PCM) inside horizontal rectangular capsules are examined experimentally. The capsules are heated isothermally and three kinds of aspect ratios (H/W = 3, 1 and 1/3) are provided. Octadecane and ice are used, respectively, as PCM. A method of analysis applying Nusselt's liquid film theory to the close-contact melting heat transfer in the rectangular capsule is presented. The analytical results show good agreement with the experimental data. For the melting of ice, it is found that the effect of natural convection resulting from density inversion of water at 4°C becomes significant for large Stefan numbers.     

Carnitine depletion during total parenteral nutrition despite oral L-carnitine supplementation

This study examined the behavioral mechanisms that support transfer of food from adults to infants in tufted capuchins (Cebus apella). Two captive groups of capuchins were presented with abundant quantities of unshelled pecans or commercial pellets. Five of 11 infant subjects could not open the nuts. A variety of tolerated interactions were initiated by infants toward adults, and food was frequently transferred. All such interactions were more frequent with nuts (a preferred food) than with pellets. Adult capuchins were equally tolerant of infant capuchins that could open nuts and those that could not. Tolerated interactions during feeding could result in acquisition of dietary information by young capuchins or to important, if intermittent, nutritional support.     

The protective effect of hyperbaric oxygenation on the small intestine in ischemia-reperfusion injury

Hyperbaric oxygenation has been used as the method of treatment in several ischemic diseases, but its effectiveness still remains controversial. The authors investigated the effect of hyperbaric oxygenation on ischemia-reperfusion injury of the small intestine using a rat model. Wistar King A Makino (WKAM) rats were subjected to 120 minutes of superior mesenteric artery occlusion before reperfusion, with 90 minutes of hyperbaric oxygenation (two absolute atmospheric pressure in an experimental hyperbaric chamber) during ischemia in group A and immediately after reperfusion in group B, and no hyperbaric oxygen was provided to group C. Jejunal samples 1.5 cm in length were taken at the end of ischemia in all groups, at 30 minutes after reperfusion in groups A and C, and at 120 minutes after reperfusion in groups B and C, for the measurement of adenine nucleotides (high-performance liquid chromatography method) and for histological examination (hematoxylineosin [HE] staining). The survival rate was significantly higher in group A than in group C. The amount of adenosine triphosphate in the samples was not significantly different among the three groups, whereas the energy charge at the end of ischemia was significantly higher in group A than in group C. Histologically, the damage to the mucosa and the longitudinal muscle layer decreased in group A compared with that observed in groups B and C. These results suggest that hyperbaric oxygenation during ischemia is able to ameliorate ischemia-reperfusion injury in the rat small intestine.     

Fluorescence EXAFS analysis of ErP grown on InP by organometallic vapor phase epitaxy using a new organometal Er(EtCp)3

We have investigated local structures of ErP grown by organometallic vapor phase epitaxy Er source: tris(ethylcyclopentadienyl)erbium (Er(EtCp)₃ by extended X-ray absorption fine structure (EXAFS) measurement. The EXAFS analysis revealed that NaCl-type ErP and Er–O(–C) compounds coexisted in the case of ErP growth by using Er(EtCp)₃. The NaCl-type ErP was preferentially formed on InP(1 1 1)A compared with InP(0 0 1) and InP(1 1 1)B. It is considered that formation of unexpected Er–O(–C) compounds is due to low but significant concentration of residual O and/or C in Er(EtCp)₃.     

Colloidal Processing and Mechanical Properties of Whisker-Reinforced Mullite Matrix Composites

Aqueous colloidal suspensions in the two systems of CVD-processed ultrafine mullite powder (<0.1 μm), -Si₃N₄ whisker and -mullite whisker, were prepared near the isoelectric point of mullite (pH 7.0) to prevent cracking during drying of wet green compacts consolidated by filtration. The freeze-dried porous green compacts were hot-pressed with a carbon die at 1500°C for 1 h at a pressure of 39 MPa in N₂ atmosphere. The relative densities of the mullite matrix composites with whiskers of 0 to 10 vol% were in the range of 95.2% to 99.8%. Increasing the fraction of Si₃N₄ whisker increased the density, flexural strength, and fracture toughness of the hot-pressed composites. On the other hand, addition of the mullite whisker increased the fracture toughness but decreased the density and strength of the composites.     

Correlation between maximum temperature increase and peak SAR with different average schemes and masses

This paper investigates the correlation between maximum temperature increases and peak spatial-average specific absorption rates (SARs), calculated by different average schemes and masses. For evaluating the effect of mass on the correlation properly, a three-dimensional Green's function is presented. From our computational investigation, no best average mass for peak spatial-average SAR exist from the aspect of the correlation with maximum temperature increase. This is attributed to the frequency dependent penetration depth of EM waves. Maximum temperature increase in the head including the pinna is reasonably correlated with peak spatial-average SARs for most average schemes and masses considered in this paper. Maximum temperature increase in the head only (excluding the pinna) is reasonably correlated with peak 10-g SARs for the average schemes considered in this paper. The rationale for this result is explained using the Green's function. The point to be stressed here is that the slope correlating them is largely dependent on the average scheme and mass. Additionally, good agreement is observed in the slopes obtained by using two head models, which have been developed at Osaka University and Nagoya Institute of Technology. However, weak correlation is observed for the brain, which is caused by the difference of the positions where peak SAR and maximum temperature increase appear. The 95th percentile values of the slope correlating maximum temperature increases in the head or brain and peak spatial-average SAR are quantified for different average schemes and masses.