Predicting the impact of subsurface heterogeneous hydraulic conductivity on the stochastic behavior of well draw down in a confined aquifer using artificial neural networks

Groundwater flow and behavior have to be investigated based on heterogeneous subsurface formation since the homogeneity assumption of this formation is not valid. Over the past twenty years, stochastic approach and Monte Carlo technique have been utilized very efficiently to understand the groundwater flow behavior. However, these techniques require lots of computational and numerical efforts according to the various researchers’ comments. Therefore, utilizing new techniques with much less computational efforts such as Artificial Neural Network (ANN) in the prediction of the stochastic behavior for the groundwater based on heterogeneous subsurface formation is highly appreciated. The current paper introduces the ANN technique to investigate and predict the stochastic behavior of a well draw down in a confined aquifer based on subsurface heterogeneous hydraulic conductivity. Several ANN models are developed in this research to predict the unsteady two dimensional well draw down and its stochastic characteristics in a confined aquifer. The results of this study showed that ANN method with less computational efforts was very efficiently capable of simulating and predicting the stochastic behavior of the well draw down resulted from the continuous constant pumping in the middle of a confined aquifer with subsurface heterogeneous hydraulic conductivity.     

Effect of grain size on the primary and secondary creep behavior of Sn–3 wt.% Bi alloy

The effect of grain size as well as creep temperature on the primary and secondary creep parameters of Sn–3 wt.% Bi alloy has been studied. It was found that the creep parameters α, β, and έ _s were decreased with increasing grain size. This was explained in view of the dislocation interaction with the defects and different inclusions in the matrix. For both the primary and secondary creep, the activation energies estimated indicate that the rate-controlling mechanism is the grain boundary-sliding mechanism.     

Coupled reliability model of biodeterioration, chloride ingress and cracking for reinforced concrete structures

Maintaining and operating civil infrastructure systems has been recognized as a critical issue worldwide. Among all possible causes of safety reduction during the structural lifetime, deterioration is particularly important. Structural deterioration is usually a slow time-dependent process controlled by safety and operation threshold specifications. This paper presents a model of RC deterioration by coupling biodeterioration (i.e., chemical, physical and mechanical action of live organisms), steel corrosion, and concrete cracking. The final purpose of the model is to compute the reduction of the concrete section and the area of steel reinforcement in order to assess the change of structural capacity with time. Given the uncertainties in both the parameters and the model, the probabilistic nature of loads, the material properties and the diffusion process are taken into account to evaluate structural reliability. The model is illustrated with an example where the inelastic behavior of a pile subject to random loading is considered. The results of the analysis have shown that the effect of biodeterioration on the structural performance is significant and can cause an important reduction of its lifetime. On the whole, the paper states that modeling the effects of biodeterioration in RC structures should be included as part of infrastructure planning and design, especially, when they are located in aggressive environments.     

Novel composite sandwich structure from green materials: Mechanical,physical, and biological evaluation

Flax and Jute fabrics were used as reinforcements with polyester resin to form composite skins while poplar particleboard was used as a core for making composite sandwich structures by applying vacuum assisted resin transfer molding (VARTM) technique. Mechanical, physical, and biological properties of these novel composite sandwich structures were evaluated. The results showed that the proposed engineered panels have superior mechanical properties that are suitable for different structural applications compared with conventional particleboards. When compared with the control panels, significant enhancement on Modulus of elasticity (MOE) and Modulus of rupture (MOR) were achieved. On the other hand, the results indicated that the proposed panel composites exhibit better dimensional stability compared with poplar particleboard control panels. In addition, the proposed composite sandwich structures proved resistant against the decay fungi after 12 weeks of fungal exposure. Obviously, the developed composite panels could be used in a wide variety of applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42253.     

A hybrid topology optimization methodology combining simulated annealing and SIMP

Structural topologies obtained by SIMP are not completely satisfactory since they exhibit areas with intermediate densities which lack physical meaning. Thus, the designer is left with the nontrivial decision of rounding and approximating the solution. This paper presents SA–SIMP, a hybrid methodology that couples simulated annealing and SIMP under a look-ahead scheme that gradually fixes or removes elements with intermediate densities (i.e., gray areas in SIMP). After designing several strategies and testing them on different structures, SA–SIMP consistently led to topologies with both lower compliances and less gray areas than those obtained by SIMP alone.     

Cyclic Flexure Tests of Masonry Walls Reinforced with Glass Fiber Reinforced Polymer Sheets

The research work reported here investigates the out-of-plane flexural behavior of masonry walls reinforced externally with glass fiber reinforced polymer (GFRP) sheets and subjected to cyclic loading. A full-scale test program consisting of eight wall specimens was conducted. Nine tests were performed, in which three parameters were studied. These included the level of compressive axial load, amount of internal steel reinforcement, and amount of externally bonded GFRP sheet reinforcement. Of the three parameters studied, varying the amount of GFRP sheets was the only parameter that significantly affected the behavior of the walls. The GFRP sheet reinforcement governed the linear response of the bending moment versus centerline deflection hysteresis. Increasing or decreasing the amount of GFRP sheet reinforcement either increased or decreased both the wall stiffness and the ultimate strength, respectively. Except for visible cracks, the walls maintained their structural integrity throughout the out-of-plane cyclic loading. The unloading/reloading paths for successive loading cycles were similar, indicating little degradation. Thus, the general behavior of the walls was very predictable. The system, therefore, could be used to advantageously rehabilitate older masonry structures that are inadequately reinforced to withstand seismic events. A simple model of the behavior is also presented to allow for the evaluation of the strength and deformation characteristics of these elements.     

Preparation and Evaluation of Directly-Compressed Indomethacin, Indomethacin Sodium and Indomethacin Meglumine Tablets

A formula containing Compactrol, Ac-Di-Sol, Aerosil 200 and talc was used to prepare directly-compressed tablets of indomethacin and its sodium and meglumine salts. The prepared tablets were evaluated for uniformity of weight and thickness, hardness, friability and content uniformity. Each batch was then divided into two, one was coated with an opaque non-enteric film coat and evaluated for coat thickness uniformity. The dissolution rates of the uncoated and coated tablets and the effect of shelf-storage, at room temperature for 11 months, on drug contents were also studied. Indomethacin meglumine tablets showed the least relative standard deviation of weight and thickness. They exhibited acceptable uniformity of content and coat thickness, and the highest hardness-friability ratio. Also exhibited, uncoated and coated, the best in-vitro release of its drug contents and the maximal stability.     

Technological,Regulatory, and Ethical Aspects of In Vitro Meat: A Future Slaughter‐Free Harvest

Defined as meat cultured in a laboratory within a bioreactor under controlled artificial conditions, in vitro meat is a relatively recent area that has opened a whole universe of possibilities and opportunities for the meat sector. With improved chemical and microbial safety and varied options, in vitro meat has been proposed as a green, healthy, environmentally friendly, and nutritionally better product that is free from animal suffering and death. Cell culture and tissue culture are the most probable technologies for the development of this futuristic muscle product. However, there are many challenges in the production of a suitable product at an industrial scale under a sustainable production system and a great body of research is required to fill the gaps in our knowledge. Many materials used in the product development are novel and untested within the food industry and demand urgent regulatory and safety assessment systems capable of managing any risks associated with the development of cultured meat. The future of this product will depend on the actions of governments and regulatory agencies. This article highlights emerging biotechnological options for the development of cultured meat and suggests ways to integrate these emerging technologies into meat research. It considers the problems and possibilities of developing cultured meat, opportunities, ethical issues as well as emerging safety and regulatory issues in this area.     

Wool keratin as a novel alternative protein: A comprehensive review of extraction,purification, nutrition,safety, and food applications

The growing global population and lifestyle changes have increased the demand for specialized diets that require protein and other essential nutrients for humans. Recent technological advances have enabled the use of food bioresources treated as waste as additional sources of alternative proteins. Sheep wool is an inexpensive and readily available bioresource containing 95%–98% protein, making it an outstanding potential source of protein for food and biotechnological applications. The strong structure of wool and its indigestibility are the main hurdles to achieving its potential as an edible protein. Although various methods have been investigated for the hydrolysis of wool into keratin, only a few of these, such as sulfitolysis, oxidation, and enzymatic processes, have the potential to generate edible keratin. In vitro and in vivo cytotoxicity studies reported no cytotoxicity effects of extracted keratin, suggesting its potential for use as a high-value protein ingredient that supports normal body functions. Keratin has a high cysteine content that can support healthy epithelia, glutathione synthesis, antioxidant functions, and skeletal muscle functions. With the recent spike in new keratin extraction methods, extensive long-term investigations that examine prolonged exposure of keratin generated from these techniques in animal and human subjects are required to ascertain its safety. Food applications of wool could improve the ecological footprint of sheep farming and unlock the potential of a sustainable protein source that meets demands for ethical production of animal protein.