Differentiation of organics from schizophrenics at two chronicity levels by use of the Reitan-Halstead Organic Test Battery.

Attempted to determine whether the Reitan-Halstead Organic Test Battery separates neuropsychiatric hospital organics from schizophrenics. It was administered to 25 schizophrenics and 25 cerebral-lesion organics at each of 2 chronicity levels. Only 1 of the 24 diagnosis/diagnosis * chronicity effects used to evaluate the data was significant at the .05 level, indicating that actuarial application of Reitan-Halstead scores is of no practical value in the separation of the 2 groups. To determine whether expert clinicians might improve upon the actuarial results, protocols of 24 schizophrenics and 24 organics were sent to 8 Reitan-Halstead experts who were instructed to separate them into brain-damaged and schizophrenic diagnostic groups. The mean number of correct classifications, 25.5 out of 48 suggested that clinical judgment added nothing to actuarial prediction in this case. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Inpatient care or outplacement: which is better for the psychiatric medically infirm patient?

Eighty-four geriatirc ward patients were randomly assigned to groups targeted for outplacement planning or inpatient care. During the following year, half of the former were placed in community settings while nearly all of the latter remained in the hospital. Neither the physical health, level of self-care, or psychiatric condition ratings of the two groups changed differentially over that time. However, the mean Morale Inventory score of the outplacement sample improved while that of the in-patient group remained static. Additional analyses were run between three groups - outplacement planning subjects who were released, those who were not released, and inpatient planning men who were not released. These results confirmed those of the first analyses; the only significant difference appeared on the Morale Inventory, the patients who left showing more improvement than the other two groups. The results argue for an increased emphasis on outplacement programs among geriatric patients.     

Attenuation and Cross-Polarization Measurements at 11 GHz

Measurements of linear cross polarization and attenuation on a terrestrial link in the U.K. are reported and correlated with rainfall information. The cross polarization measured during rainfall is compared with theoretically predicted values and monthly cross-polar statistics are presented for a 16-month period.     

Slant-path microwave radio propagation through distorted raindrops

Attenuation and phase coefficients are evaluated for microwave radio propagation through oblate spheroidal raindrops on slant radio paths. From these coefficients, it is evident that the resultant crosspolarisation for linearly or circularly polarised waves should be significantly less on satellite radio paths than on horizontal radio paths.     

Effective numerical treatment of boundary integral equations: A formulation for three-dimensional elastostatics

The field equations of three-dimensional elastostatics are transformed to boundary integral equations. The elastic body is divided into subregions, and the surface and interfaces are represented by quadrilateral and triangular elements with quadratic variation of geometry and linear, quadratic or cubic variation of displacement and traction with respect to intrinsic co-ordinates. The integral equation is discretized for each subregion, and a system of banded form obtained. For the integration of kernel-shape function products, Gaussian quadrature formulae are chosen according to upper bounds for error in terms of derivatives of the integrands. Use of the integral formulation is illustrated by the analysis of a prestressed concrete nuclear reactor pressure vessel.     

Interrelationships of several process-reactive measures.

94 schizophrenic patients served as Ss. 8 previously used and potential process-reactive measures were intercorrelated and factored by the principal-factor solution. 2 factors were rotated. The 1st factor, consisting of marital status and the Philips, Elgin, and Ullmann-Giovannoni scales, consisted of traditional process-reactive measures. The variables making up the 2nd factor do not appear to be appropriate process-reactive indices. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

In vivo characterisation of a novel bioresorbable poly(lactide-co-glycolide) tubular foam scaffold for tissue engineering applications

Polylactide-co-glycolide (PLGA) foams of tubular shape were assessed for their use as soft-tissue engineering scaffolds in vitro and in vivo. Porous membranes were fabricated by a thermally induced phase separation process of PLGA solutions in dimethylcarbonate. The parameters investigated were the PLGA concentration and the casting volume of solution. Membranes produced from 5 wt/v % polymer solutions and a 6 ml casting volume of polymer solution were selected for fabricating tubes of 3 mm diameter, 20 mm length and a nominal wall thickness of 1.5 mm. Scanning electron microscopy revealed that the structure of the tubular foams consisted of radially oriented and highly interconnected pores with a large size distribution (50-300 microm). Selected tubes were implanted subcutaneously into adult male Lewis rats. Although the lumen of the tubes collapsed within one week of implantation, histological examination of the implanted scaffolds revealed that the foam tubes were well tolerated. Cellular infiltration into the foams, consisting mainly of fibrovascular tissue, was evident after two weeks and complete within eight weeks of implantation. The polymer was still evident in the scaffolds after eight weeks of implantation. The results from this study demonstrate that the PLGA tubular foams may be useful as soft-tissue engineering scaffolds with modification holding promise for the regeneration of tissues requiring a tubular shape scaffold such as intestine.     

Sonification supports eyes-free respiratory monitoring and task time-sharing

Three experiments explored the effectiveness of continuous auditory displays, or sonifications, for conveying information about a simulated anesthetized patient's respiration. Experiment 1 established an effective respiratory sonification. Experiment 2 showed an effect of expertise in the use of respiratory sonification and revealed that some apparent differences in sonification effectiveness could be accounted for by response bias. Experiment 3 showed that sonification helps anesthesiologists to maintain high levels of awareness of the simulated patient's state while performing other tasks more effectively than when relying upon visual monitoring of the simulated patient state. Overall, sonification of patient physiology beyond traditional pulse oximetry appears to be a viable and useful adjunct to visual monitors. Actual and potential applications of this research include monitoring in a wide variety of busy critical care contexts.     

Real-time surface plasmon resonance imaging measurements for the multiplexed determination of protein adsorption/desorption kinetics and surface enzymatic reactions on peptide microarrays

The kinetics of protein adsorption/desorption onto peptide microarrays was studied using real-time surface plasmon resonance (SPR) imaging. S protein binding interactions were examined using an array composed of five different peptides: N terminal and C terminal immobilized wild-type S peptide (S1 and S2), an alternate binding sequence derived by phage display (LB2), an NVOC-protected S peptide, and a FLAG peptide control sequence (F). Kinetic measurements of the S protein-S1 peptide interaction were analyzed to determine a desorption rate constant (k(d)) of 1.1 (+/-0.08) x 10(-2) s(-1), an adsorption rate constant (k(a)) of 1.9 (+/-0.05) x 10(5) M(-1) s(-1), and an equilibrium adsorption constant (K(Ads)) of 1.7 (+/-0.08) x 10(7) M(-1). SPR imaging equilibrium measurements of S protein to S1 peptide were performed to independently confirm the kinetically determined value of K(Ads). Rate constants for the S2 and LB2 peptides on the array were measured as follows: 1.6 (+/-0.04) x 10(5) M(-1) s(-1) (k(a)) and 1.1 (+/-0.07) x 10(-2) s(-1) (k(d)) for S2, 1.2 (+/-0.05) x 10(5) M(-1) s(-1) (k(a)) and 1.1 (+/-0.03) x 10(-2) s(-1) (k(d)) for LB2. In addition to S protein adsorption/desorption, real-time SPR imaging of peptide arrays was applied to study the surface enzymatic activities of the protease factor Xa. Enzymatic cleavage of the substrate peptide (P1) was shown to follow first-order kinetics and proceed at a rate 10 times faster than that of the mutant peptide (P2), with cleavage velocities of 5.6 (+/-0.3) x 10(-4) s(-1) for P1 and 5.7 (+/-0.3) x 10(-5) s(-1) for P2.