Optimal neuronal tuning for finite stimulus spaces

The efficiency of neuronal encoding in sensory and motor systems has been proposed as a first principle governing response properties within the central nervous system. We present a continuation of a theoretical study presented by Zhang and Sejnowski, where the influence of neuronal tuning properties on encoding accuracy is analyzed using information theory. When a finite stimulus space is considered, we show that the encoding accuracy improves with narrow tuning for one- and two-dimensional stimuli. For three dimensions and higher, there is an optimal tuning width.     

Non-destructive methods for space charge distribution measurements: what are the differences?

For more than 25 years, various techniques have been introduced for the nondestructive measurement of the space charge distribution in solid dielectrics. All these techniques can be classified into a set of three methods: (i) the thermal method, (ii) the pressure-wave-propagation method and (iii) the electro-acoustic method. Despite their apparent differences they are based on the same physical idea: the perturbation of the equilibrium between electrostatic and elastic forces in the material induces a response, either electrical or mechanical, which can be analyzed. In this paper, we demonstrate that the information on the material contained in the response is identical whatever the method used. As a consequence the differences between methods stand only in the nature of the perturbation and its physical properties.     

Linear shape from shading

In many situations the reflectance function of a surface is approximately linear, and there is an effielent closed-form solution to the shape-from-shading problem. When boundary conditions (e.g., edges, singular points) are not available, good estimates of shape may still be extracted by using the assumption of general viewing position. An improved method for estimating the illuminant direction is also presented.     

Therapeutic Vaccines for HPV-Associated Oropharyngeal and Cervical Cancer: The Next De-Intensification Strategy?

The rise in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has prompted a quest for further understanding of the role of high-risk HPV in tumor initiation and progression. Patients with HPV-positive OPSCC (HPV+ OPSCC) have better prognoses than their HPV-negative counterparts; however, current therapeutic strategies for HPV+ OPSCC are overly aggressive and leave patients with life-long sequalae and poor quality of life. This highlights a need for customized treatment. Several clinical trials of treatment de-intensification to reduce acute and late toxicity without compromising efficacy have been conducted. This article reviews the differences and similarities in the pathogenesis and progression of HPV-related OPSCC compared to cervical cancer, with emphasis on the role of prophylactic and therapeutic vaccines as a potential de-intensification treatment strategy. Overall, the future development of novel and effective therapeutic agents for HPV-associated head and neck tumors promises to meet the challenges posed by this growing epidemic.     

Glioblastoma Extracellular Vesicle-Specific Peptides Inhibit EV-Induced Neuronal Cytotoxicity

WHO Grade 4 IDH-wild type astrocytoma (GBM) is the deadliest brain tumor with a poor prognosis. Meningioma (MMA) is a more common “benign” central nervous system tumor but with significant recurrence rates. There is an urgent need for brain tumor biomarkers for early diagnosis and effective treatment options. Extracellular vesicles (EVs) are tiny membrane-enclosed vesicles that play essential functions in cell-to-cell communications among tumor cells. We aimed to identify epitopes of brain tumor EVs by phage peptide libraries. EVs from GBM plasma, MMA plasma, or brain tumor cell lines were used to screen phage-displayed random peptide libraries to identify high-affinity peptides. We purified EVs from three GBM plasma pools (23 patients), one MMA pool (10 patients), and four brain tumor cell lines. We identified a total of 21 high-affinity phage peptides (12 unique) specific to brain tumor EVs. The peptides shared high sequence homologies among those selected by the same EVs. Dose–response ELISA demonstrated that phage peptides were specific to brain tumor EVs compared to controls. Peptide affinity purification identified unique brain tumor EV subpopulations. Significantly, GBM EV peptides inhibit brain tumor EV-induced complement-dependent cytotoxicity (necrosis) in neurons. We conclude that phage display technology could identify specific peptides to isolate and characterize tumor EVs.     

Mass Spectrometry-Based Disulfide Mapping of Lysyl Oxidase-like 2

Lysyl oxidase-like 2 (LOXL2) catalyzes the oxidative deamination of peptidyl lysines and hydroxylysines to promote extracellular matrix remodeling. Aberrant activity of LOXL2 has been associated with organ fibrosis and tumor metastasis. The lysine tyrosylquinone (LTQ) cofactor is derived from Lys653 and Tyr689 in the amine oxidase domain via post-translational modification. Based on the similarity in hydrodynamic radius and radius of gyration, we recently proposed that the overall structures of the mature LOXL2 (containing LTQ) and the precursor LOXL2 (no LTQ) are very similar. In this study, we conducted a mass spectrometry-based disulfide mapping analysis of recombinant LOXL2 in three forms: a full-length LOXL2 (fl-LOXL2) containing a nearly stoichiometric amount of LTQ, Δ1-2SRCR-LOXL2 (SRCR1 and SRCR2 are truncated) in the precursor form, and Δ1-3SRCR-LOXL2 (SRCR1, SRCR2, SRCR3 are truncated) in a mixture of the precursor and the mature forms. We detected a set of five disulfide bonds that is conserved in both the precursor and the mature recombinant LOXL2s. In addition, we detected a set of four alternative disulfide bonds in low abundance that is not associated with the mature LOXL2. These results suggest that the major set of five disulfide bonds is retained post-LTQ formation.     

Factors facilitating or impeding older adults’ creative contributions in the collaborative design of a novel DTV-based application

This article describes some of the challenges of supporting older adults’ creative input to the design of an (as yet) undefined digital television application. Focusing on commonly used brainstorming and paper prototyping techniques, constructive insights are gathered from users with limited experience of interactive technology. Encouraging older participants to move beyond what they are familiar with, the research reports on how fragmented conceptual knowledge of familiar technologies can either facilitate or impede the creative development of new ideas. This includes bias or contradictory ideas that can emerge in the elicitation process. As reported, other factors, such as the self-perception of inadequate drawing skills, demonstrate further barriers for some older adults to articulate their visions and aspirations for suitably designed technology.     

Thanks, but I'm used to better: A relative rank model of gratitude.

We argue that more help does not necessarily lead to more gratitude. Rather, gratitude depends on how a given instance of help compares with the help that a person is used to receiving. Participants read vignettes detailing an event in which 11 different friends either lent them varying amounts of money or spent varying amounts of time providing help. The amount of gratitude elicited by a given amount of help (e.g., a loan of ￡36 [about $56] or 49 min help) differed substantially depending on how this amount ranked among the help they were getting from their other friends. Comparison across four experimental conditions suggested that these judgments operated via the same general cognitive mechanisms used to judge other social events and psychophysical stimuli (as outlined by range frequency theory). Although more help does lead to more gratitude, people appear to be sensitive to how that help compares with what others are providing, and experienced gratitude depends on these relative judgments. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

The research productivity of academic psychologists: assessment,trends, and best practice recommendations

Research productivity affects the careers of academic psychologists. Unfortunately, there is a surprising lack of consensus on productivity’s meaning, measurement, and how to compare the productivity of one academic psychologist to another. In the present study, we review academic productivity research within psychology, and using a sample of 673 psychologists, compute six indexes of productivity. Most productivity metrics (publication count, citation count, or some combination of the two) were substantially interrelated and one (Integrated Research Productivity Index) was independent from years in the field. Female psychologists were equally as productive as male psychologists after accounting for years in the field, and pre-tenure psychologists showed steeper change-over-time productivity slopes than post-tenure psychologists. Based on these findings, we provide recommendations for the use and measurement of academic research productivity.