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61.
Amanda M. Levy Paulino Gomez-Puertas Zeynep Tümer 《International journal of molecular sciences》2022,23(8)
The postsynaptic density (PSD) is a massive protein complex, critical for synaptic strength and plasticity in excitatory neurons. Here, the scaffolding protein PSD-95 plays a crucial role as it organizes key PSD components essential for synaptic signaling, development, and survival. Recently, variants in DLG4 encoding PSD-95 were found to cause a neurodevelopmental disorder with a variety of clinical features including intellectual disability, developmental delay, and epilepsy. Genetic variants in several of the interaction partners of PSD-95 are associated with similar phenotypes, suggesting that deficient PSD-95 may affect the interaction partners, explaining the overlapping symptoms. Here, we review the transmembrane interaction partners of PSD-95 and their association with neurodevelopmental disorders. We assess how the structural changes induced by DLG4 missense variants may disrupt or alter such protein–protein interactions, and we argue that the pathological effect of DLG4 variants is, at least partly, exerted indirectly through interaction partners of PSD-95. This review presents a direction for functional studies to elucidate the pathogenic mechanism of deficient PSD-95, providing clues for therapeutic strategies. 相似文献
62.
Twambo Hachibamba Linda Dykes Joseph Awika Amanda Minnaar Kwaku G. Duodu 《International Journal of Food Science & Technology》2013,48(12):2638-2649
Consumption of diets rich in phenolic compounds has been associated with reduced risk of chronic diseases. The effect of cooking and simulated gastrointestinal digestion on phenolic compounds and antioxidant properties of two cowpea (Vigna unguiculata) types was determined. Phenolic acids, flavan‐3‐ols and flavonols were the main groups of phenolic compounds identified. Cooking and simulated enzyme digestion of the cooked cowpea samples rendered some phenolics less extractable (possibly by promoting binding with other food components) or more extractable (possibly by release of bound forms). Total phenolic contents and radical scavenging properties of the cowpeas were reduced upon cooking, but increased upon simulated enzyme digestion. Cowpea extracts inhibited human LDL oxidation at a concentration of 2 mg mL?1 possibly due to their phenolic content. Phenolic compounds in cowpea can potentially protect against cardiovascular diseases for which LDL oxidation is a risk factor. 相似文献
63.
Amanda Seemungal Andrea Petróczi Declan P. Naughton 《European Food Research and Technology》2011,233(5):781-789
Several studies have assessed total anti-oxidant activity of wine or individual components in isolation using chemical-based
assays. In this study, a quantitative approach was developed to assess the relative anti-oxidant efficacies of selected red
wine phenolics via peak reduction, using reversed-phase HPLC. Both intact red wine and phenolic standard solutions were challenged
with five oxidant model systems as follows: (1) hydrogen peroxide (H2O2); redox-active metal ions (2) Fe3+ and (3) Cu2+; and the Fenton reagents (4) H2O2 + Fe2+; and (5) H2O2 + Cu+. Treatment with oxidants (1–3) resulted in loss of 47–60% of phenolic standards, which increased to 66–89% for treatment
with the Fenton systems, with quercetin exhibiting the optimal anti-oxidant activity. For intact red wine, treatment with
oxidants (1–3) led to all phenolic compounds being oxidised (27–77% loss), with caffeic acid and quercetin as the most effective
anti-oxidants. For both Fenton systems (4–5), activities in red wine were considerably enhanced for caffeic acid and quercetin,
which exhibited the highest anti-oxidant efficacies with 100% peak reduction, while p-coumaric acid and gallic acid were less effective anti-oxidants with peak reductions of 60–68%. The ranking, facilitated
by this new quantitative approach, allows comparison of the individual efficacies of the anti-oxidants in a complex matrix. 相似文献
64.
C. Celeste Trujillo Amanda J. Wright 《Journal of the American Oil Chemists' Society》2010,87(7):715-730
Solid lipid particles (SLP) are one strategy for encapsulating lipophilic molecules, including for controlled release and
enhanced bioavailability applications. SLP based on fully hydrogenated canola stearin (CaSt, 5, 10, 20, and 30 wt%) and the
non-ionic surfactant Poloxamer 188 (P188, 0.0, 0.5, 1.0, 2.5, 5.0 and 10.0 wt%) were produced by high pressure melt homogenization
using a microfluidizer. Spherical particles in the region of 140 nm were formed, depending on compostion and processing parameters.
Surfactant concentration and pressure had a significant influence on particle diameter (P < 0.05), although number of homogenization cycles did not (P > 0.05). A maximum surfactant surface load of approximately 4 mg m−2 was observed and, at or above 2.5% P188, excess surfactant was present in the continuous phase after production. P188 had
the effect of decreasing particle size and facilitating transitions from the α to the β polymorph (P < 0.05) both through surface nucleation and size reduction effects. A stability study of the 10% CaSt SLP with 0.0, 1.0,
or 5.0% P188 revealed particle growth for the 0.0 and 1.0% P188 SLP, especially at 20 versus 4 °C, but no changes in the 5.0%
P188 SLP, which were exclusively in the β form, at both temperatures for up to 240 days. 相似文献
65.
Eoin Devereux Amanda Haynes Martin J. Power 《Journal of Housing and the Built Environment》2011,26(2):123-142
By triangulating analyses of content and reception with a focus on production, this article attempts to understand the dynamics
of and underlying reasons for the media stigmatisation of place. The research described contributes to a body of work examining
how mass media and other social forces factor in the creation of negative stereotypes that damage the reputations of the places
in which the poor reside. The overarching framework of understanding, provided by Goffman’s theory of stigma, is complemented
by two further inter-related theoretical approaches, namely Social Exclusion and Political Economy. Combining analyses of
media production (practices), media content (discourses) and audience reception (beliefs, attitudes), we analyse the representation
of one of Ireland’s most deprived public housing estates in the print and broadcast media. Having established the stigmatising
character and impact of national and local media content via this tripartite methodology, we focus on identifying and explaining
the media practices that serve to (re)produce the estate’s ‘spoiled identity’. Our analysis of journalists’ explanations for
these practices identifies the commercial realities, which progressively influence media production, as directly impacting
media producers’ relationships with, and depictions of, poor places. We conclude by examining debates regarding the potential
for rehabilitating a spoiled identity. 相似文献
66.
Chander Shekhar Sharma Amanda Ates Poulson Joseph Kamlesh A. Soni M. Wes Schilling Aaron Kiess 《International Journal of Food Science & Technology》2013,48(7):1410-1415
The efficacy of lauric arginate (LAE) on Salmonella survivability in ground chicken containing 9.8% fat was determined under refrigerated storage. The effect of LAE treatments on total aerobes, pH and objective colour were also assessed in ground chicken. LAE was highly effective against Salmonella in 0.1% peptone with no detectable survivors following treatment with 200 ppm and 400 ppm of LAE. No difference existed (P > 0.05) in the growth of Salmonella and total aerobes after treatment with 200 and 400 ppm of LAE in ground chicken inoculated with a four strain mixture of Salmonella. At these concentrations, LAE did not exhibit any treatment effect on the pH and colour of ground chicken (P > 0.05). In conclusion, although LAE possesses strong inhibitory (P < 0.05) effect against Salmonella in suspension in 0.1% peptone water, no inhibitory (P > 0.05) effect on growth of Salmonella was observed in ground chicken at the currently approved levels of 200 ppm of LAE. 相似文献
67.
Amanda N. Elkins Eric R. Muth Adam W. Hoover Alexander D. Walker Thomas L. Carpenter Fred S. Switzer 《Applied ergonomics》2009,40(6):997-1003
Physiological compliance (PC) refers to the correlation between physiological measures of team members over time. The goals of this study were to examine ways of measuring PC in heart rate variability (HRV) data and the relationship between PC and team performance. Teams were tasked with entering both real and simulated rooms and “shooting” individuals with a weapon and identifying individuals without a weapon. The linear correlation and directional agreement PC methods were shown to be the most sensitive to differences in performance, with greater PC being associated with better performance. The correlation method when applied to a measure of respiratory sinus arrhythmia (RSA) revealed a significant difference between high and low performers (t[8] = −2.31, p = 0.03) and the directional agreement applied to inter-beat-intervals and RSA revealed trend-level differences (t[4.62] = −1.86, p = 0.06 and t[8] = −1.68, p = 0.07). These results suggest that PC may have merit for predicting team performance. 相似文献
68.
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70.
Jun Wang Cheuk Tang Mario G. Ferruzzi Bing Gong Brian J. Song Elsa M. Janle Tzu‐Ying Chen Bruce Cooper Merina Varghese Alice Cheng Daniel Freire Amanda Bilski Jessica Roman Tuyen Nguyen Lap Ho Stephen T. Talcott James E. Simon Qingli Wu Giulio M. Pasinetti 《Molecular nutrition & food research》2013,57(12):2091-2102