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121.
Presents an overview of the development of a science of human abilities and discusses some of the criticisms of the derivative technology of mental testing. The criticisms concern the general misunderstanding of the premises and methodologies of mental-ability research, the magnification of disputes about technical issues that have little practical import, and the premature conversion of theoretical understandings of intelligence into the meaning and interpretation of IQ scores. A plea is entered for support of an objective science of mental abilities by the public and by the psychological profession at large. (54 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
122.
In the event of a water leak into the sodium in a sodium-water heat exchanger the products of the reaction must be vented from the system. In order to predict the possible behaviour of the two-phase reaction products as they are expelled through the venting system an analysis has been performed to determine the speed of sound and the factors affecting the onset of choking in a gas—liquid bubble flow. In particular the influence of velocity and temperature non-equilibrium between the phases is examined. 相似文献
123.
The absolute scotopic limen for light intensity was measured for three 10-mo-old female coyotes. The methodology was similar to that used by Blough in determining psychophysical thresholds in pigeons. Three coyotes were operantly conditioned to depress one of two foot treadles, left or right, depending on the condition of the stimulus light. Scotopic adaptation curves for each coyote were generated. Nonlinear regression curves were then fitted to the raw data. The mean scotopic thresholds did not differ significantly. However, time to the curves' asymptotes did differ significantly for one of the coyotes. The adaptation curves showed a distinct rod-cone "break," and retinal histology confirmed that the coyote has a duplex retina with a preponderance of rods. In addition, electroretinographic analysis showed the relative contributions of rods and cones at various light intensities and indicated a rod-cone break at approximately 15 min. Scotopic spectral sensitivity curves were also generated. The coyotes' scotopic visual threshold is exceeded by the natural illumination available under many nocturnal conditions. The results are discussed in relation to the ecology of the species. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
124.
Thirty-six lactating Holstein cows were in a 5 × 3 factorial partially balanced incomplete block design with three missing categories to study effects of different forms of cottonseed hulls and liquid supplements on milk production and composition. Roughages were regular cottonseed hulls, pelleted cottonseed hulls, pelleted cottonseed hulls with 9% fat, pelleted undelinted cottonseed hulls, and pelleted undelinted cottonseed hulls with 9% fat. Liquid supplements were 8% Masonex2 (hemicellulose extract) and 8% cane molasses. Control had no supplement. All rations were adjusted to contain 30% cottonseed hulls. Roughages with added fat gave total rations of 2.5% added fat (air dry).Least square means for daily intake of dry matter, milk yield, and fat percent were regular cottonseed hulls 21.6 kg, 20.3 kg, 3.37%; pelleted cottonseed hulls 20.3 kg, 21.4 kg, 3.06%; pelleted cottonseed hulls plus fat 20.1 kg, 21.2 kg, 2.51%; pelleted undelinted cottonseed plus fat 19.4 kg, 20.9 kg, 2.73%. Pelleted cottonseed hulls increased milk yield, decreased dry matter intake and milk fat percent, but did not affect milk fat yields. Rations with pelleted undelinted cottonseed hulls resulted in higher milk fat percent and body weight than pelleted cottonseed hulls. Added fat decreased milk fat percent and yield because of high degree of unsaturation. Liquid treatments produced no detectable effects on dry matter intake, milk yield, or fat percent. 相似文献
125.
126.
K Buschard K Josefsen T Horn S Larsen P Fredman 《Canadian Metallurgical Quarterly》1993,101(12):963-970
Clinical coincidence between diabetes and neurological disorders, and sharing of antigen determinants between islets of Langerhans and neural tissue, has been suggested. Sulphatide is a neural epitope which can be visualized with a monoclonal antibody Sulph I. Different tissues were examined by immunohistological methods. Sulphatide and anti-sulphatide antibodies were determined by thin-layer chromatographic techniques. IgG was isolated using protein A columns. A specific staining by Sulph I was found of rat islets, assigned to the secretory granules of both alpha and beta cells. No labelling of the exocrine tissue or other body tissues was seen, except for nerve and kidney structures. The latter showed staining of the distal tubules and, in addition, but only in the diabetic kidney, of glomeruli located in the subendothelial area in the capillary loops and the mesangial space. Sera from 38% of 40 spontaneously diabetic BB rats displayed anti-sulphatide antibodies, mainly IgG, whereas all 30 control Lewis rats were negative. Most recently we have demonstrated anti-sulphatide antibodies in 88% of 57 patients with newly diagnosed Type 1 diabetes (titres of > 1:400); all 135 healthy control persons were negative. The sulphatide antibody reactivity was present in the IgG fractions of the patients' sera. Thus, sulphatide is demonstrated in islets of Langerhans and in kidney related to the diabetic lesion, and, furthermore, anti-sulphatide antibodies exist in Type 1 diabetes mellitus. 相似文献
127.
The voltage sensor of the sodium channel is mainly comprised of four positively charged S4 segments. Depolarization causes an outward movement of S4 segments, and this movement is coupled with opening of the channel. A mutation that substitutes a cysteine for the outermost arginine in the S4 segment of the second domain (D2:R1C) results in a channel with biophysical properties similar to those of wild-type channels. Chemical modification of this cysteine with methanethiosulfonate-ethyltrimethylammonium (MTSET) causes a hyperpolarizing shift of both the peak current-voltage relationship and the kinetics of activation, whereas the time constant of inactivation is not changed substantially. A conventional steady state inactivation protocol surprisingly produces an increase of the peak current at -20 mV when the 300-ms prepulse is depolarized from -190 to -110 mV. Further depolarization reduces the current, as expected for steady state inactivation. Recovery from inactivation in modified channels is also nonmonotonic at voltages more hyperpolarized than -100 mV. At -180 mV, for example, the amplitude of the recovering current is briefly almost twice as large as it was before the channels inactivated. These data can be explained readily if MTSET modification not only shifts the movement of D2/S4 to more hyperpolarized potentials, but also makes the movement sluggish. This behavior allows inactivation to have faster kinetics than activation, as in the HERG potassium channel. Because of the unique properties of the modified mutant, we were able to estimate the voltage dependence and kinetics of the movement of this single S4 segment. The data suggest that movement of modified D2/S4 is a first-order process and that rate constants for outward and inward movement are each exponential functions of membrane potential. Our results show that D2/S4 is intimately involved with activation but plays little role in either inactivation or recovery from inactivation. 相似文献
128.
Tan H Ezekoye OK Van der Schalie J Horn MW Lakhtakia A Xu J Burgos WD 《Environmental science & technology》2006,40(17):5490-5495
Sculptured thin films (STFs) are assemblies of nominally identical, parallel nanowires with tailored shapes such as chevrons and spirals. A series of iron(lll) STFs were produced with varied crystallinity (from hematite toferrihydrite) and nanowire shapes (slanted columnar, clockwise helical, and counterclockwise helical). When the dissimilatory metal-reducing bacterium Shewanella putrefaciens CN32 was used to measure their bioreducibility, it was found that bioreduction was controlled primarily by oxide crystallinity. STFs were characterized by scanning electron microscopy, atomic force microscopy, and grazing incidence small-angle X-ray scattering. Postbioreduction characterizations determined that mineralogy of the film materials did not change, but surface roughness generally increased. Changes caused by bioreduction were assessed in terms of both transmittance and reflectance of light incident normal to the STFs. The greatest optical changes were obtained with crystalline hematite films. These results underscore the feasibility of an STF-based fiber optic iron(lll) reduction sensor for in situ subsurface deployment. 相似文献
129.
130.
Hui Huang Bradi R. Lorenz Paula Horn Zelmanovitz Catherine B. Chan 《International journal of molecular sciences》2021,22(1)
Prediabetes is a high-risk condition for type 2 diabetes (T2D). Pancreatic β-cells adapt to impaired glucose regulation in prediabetes by increasing insulin secretion and β-cell mass expansion. In people with prediabetes, metformin has been shown to prevent prediabetes conversion to diabetes. However, emerging evidence indicates that metformin has negative effects on β-cell function and survival. Our previous study established the Nile rat (NR) as a model for prediabetes, recapitulating characteristics of human β-cell compensation in function and mass expansion. In this study, we investigated the action of metformin on β-cells in vivo and in vitro. A 7-week metformin treatment improved glucose tolerance by reducing hepatic glucose output and enhancing insulin secretion. Although high-dose metformin inhibited β-cell glucose-stimulated insulin secretion in vitro, stimulation of β-cell insulin secretion was preserved in metformin-treated NRs via an indirect mechanism. Moreover, β-cells in NRs receiving metformin exhibited increased endoplasmic reticulum (ER) chaperones and alleviated apoptotic unfold protein response (UPR) without changes in the expression of cell identity genes. Additionally, metformin did not suppress β-cell mass compensation or proliferation. Taken together, despite the conflicting role indicated by in vitro studies, administration of metformin does not exert a negative effect on β-cell function or cell mass and, instead, early metformin treatment may help protect β-cells from exhaustion and decompensation. 相似文献