Integrated vaccination and non-pharmaceutical interventions based strategies in Ontario,Canada, as a case study: a mathematical modelling study

Recently, two coronavirus disease 2019 (COVID-19) vaccine products have been authorized in Canada. It is of crucial importance to model an integrated/combined package of non-pharmaceutical (physical/social distancing) and pharmaceutical (immunization) public health control measures. A modified epidemiological, compartmental SIR model was used and fit to the cumulative COVID-19 case data for the province of Ontario, Canada, from 8 September 2020 to 8 December 2020. Different vaccine roll-out strategies were simulated until 75% of the population was vaccinated, including a no-vaccination scenario. We compete these vaccination strategies with relaxation of non-pharmaceutical interventions. Non-pharmaceutical interventions were supposed to remain enforced and began to be relaxed on 31 January, 31 March or 1 May 2021. Based on projections from the data and long-term extrapolation of scenarios, relaxing the public health measures implemented by re-opening too early would cause any benefits of vaccination to be lost by increasing case numbers, increasing the effective reproduction number above 1 and thus increasing the risk of localized outbreaks. If relaxation is, instead, delayed and 75% of the Ontarian population gets vaccinated by the end of the year, re-opening can occur with very little risk. Relaxing non-pharmaceutical interventions by re-opening and vaccine deployment is a careful balancing act. Our combination of model projections from data and simulation of different strategies and scenarios, can equip local public health decision- and policy-makers with projections concerning the COVID-19 epidemiological trend, helping them in the decision-making process.     

Affective sanctuaries: understanding Maggie’s as therapeutic landscapes

Abstract

Since 1996, Maggie’s has led a new approach to cancer support that emphasises the empowering potential of the designed environment for its users. This paper draws on qualitative research from two separate projects undertaken with staff, visitors and volunteers at 10 Maggie’s Centres, exploring their experiences of Maggie’s environments, and their use of internal spaces and garden areas. Maggie’s has been most often noted for the buildings it commissions, but we argue that the gardens prompt a re-evaluation of the integrated healing environment. Locating our research in health geography debates, Maggie’s buildings and gardens are situated as contemporary examples of therapeutic landscapes. The Centres open up debates about the capacity of the designed environment to enhance the experience of well-being. This is achieved through the provision of communal areas within which visitors can find private places for emotional retreat, encouraging the experience of affective sanctuary.     

Creativity and cognitive style: The relationship between field-dependence-independence, expected evaluation, and creative performance.

This study explored the effects of cognitive style and expected evaluation on creativity. Past research has shown that an expectation of evaluation can have a negative impact on creativity. In addition, those individuals classified as field-independent rather than field-dependent are more likely to have higher creativity scores. Thus, an interaction between expected evaluation and cognitive style was hypothesized, along with main effects for expectation of evaluation and cognitive style. Participants created a collage to measure creativity, either with or without an expectation of evaluation, and then cognitive style was measured using the Group Embedded Figures Test (GEFT). The hypothesis was partially supported. The more field-independent an individual, the higher the creativity score. Despite the results of previous research, evaluation condition did not significantly affect creativity; this finding is discussed in terms of the experimental situation and the conceptualization of motivation. Further investigations of cognitive style and motivational conditions are suggested. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Emotion and aging: Experience, expression, and control.

Age differences in emotional experience, expression, and control were investigated in 4 studies. A community sample of 127 African Americans and European Americans (ages 19–96 years) was used in Study 1; a community sample of 82 Chinese Americans and European Americans (ages 20–85 years) was used in Study 2; a community sample of 49 Norwegians drawn from 2 age groups (ages 20–35 years and 70+ years) was used in Study 3; and a sample of 1,080 American nuns (ages 24–101 years) was used in Study 4. Across studies, a consistent pattern of age differences emerged. Compared with younger participants, older participants reported fewer negative emotional experiences and greater emotional control. Findings regarding emotional expressivity were less consistent, but when there were age differences, participants reported lesser expressivity. Results are interpreted in terms of increasingly competent emotion regulation across the life span. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of Recess on the Classroom Behavior of Children With and Without Attention-Deficit Hyperactivity Disorder.

The primary purpose of this study was to evaluate the effects of a traditional recess on the subsequent classroom behavior of children with a diagnosis of Attention-Deficit Hyperactivity Disorder (ADHD). In addition, the time of recess was matched to the behavior of the individual children diagnosed with ADHD based on prior assessment of their classroom behavior as a function of time of confinement in the classroom. All results were evaluated using single-case designs. Results showed that levels of inappropriate behavior were consistently higher on days when participants did not have recess, compared with days when they did have recess. Results also showed that the level of inappropriate behavior for all participants progressively increased over time on days when they did not have recess. However, this progressive increase did not occur on days when the participants had recess. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Velocity-based motion categorization by pigeons.

To examine if animals could learn action-like categorizations in a manner similar to noun-based categories, eight pigeons were trained to categorize rates of object motion. Testing 40 different objects in a go/no-go discrimination, pigeons were first trained to discriminate between fast and slow rates of object rotation around their central y-axis. They easily learned this velocity discrimination and transferred it to novel objects and rates. This discrimination also transferred to novel types of motions including the other two axes of rotation and two new translations around the display. Comparable tests with rapid and slow changes in the objects' size, color, and shape failed to support comparable transfer. This difference in discrimination transfer between motion-based and property-based changes suggests the pigeons had learned motion concept rather than one based on change per se. The results provide evidence that pigeons can acquire an understanding of motion-based actions, at least with regard to the property of object velocity. This may be similar to our use of verbs and adverbs to categorize different classes of behavior or motion (e.g., walking, jogging, or running slow vs. fast). (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Investigating the decay rates of Escherichia coli relative to Vibrio parahemolyticus and Salmonella Typhi in tropical coastal waters

Using the size fractionation method, we measured the decay rates of Escherichia coli, Salmonella Typhi and Vibrio parahaemolyticus in the coastal waters of Peninsular Malaysia. The size fractions were total or unfiltered, <250 μm, <20 μm, <2 μm, <0.7 μm, <0.2 μm and <0.02 μm. We also carried out abiotic (inorganic nutrients) and biotic (bacterial abundance, production and protistan bacterivory) measurements at Port Dickson, Klang and Kuantan. Klang had highest nutrient concentrations whereas both bacterial production and protistan bacterivory rates were highest at Kuantan. We observed signs of protist-bacteria coupling via the following correlations: Protistan bacterivory−Bacterial Production: r = 0.773, df = 11, p < 0.01; Protist−Bacteria: r = 0.586, df = 12, p < 0.05. However none of the bacterial decay rates were correlated with the biotic variables measured. E. coli and Salmonella decay rates were generally higher in the larger fraction (>0.7 μm) than in the smaller fraction (<0.7 μm) suggesting the more important role played by protists. E. coli and Salmonella also decreased in the <0.02 μm fraction and suggested that these non-halophilic bacteria did not survive well in seawater. In contrast, Vibrio grew well in seawater. There was usually an increase in Vibrio after one day incubation. Our results confirmed that decay or loss rates of E. coli did not match that of Vibrio, and also did not correlate with Salmonella decay rates. However E. coli showed persistence where its decay rates were generally lower than Salmonella.     

Proteomics of Mouse Heart Ventricles Reveals Mitochondria and Metabolism as Major Targets of a Post-Infarction Short-Acting GLP1Ra-Therapy

Cardiovascular disease is the main cause of death worldwide, making it crucial to search for new therapies to mitigate major adverse cardiac events (MACEs) after a cardiac ischemic episode. Drugs in the class of the glucagon-like peptide-1 receptor agonists (GLP1Ra) have demonstrated benefits for heart function and reduced the incidence of MACE in patients with diabetes. Previously, we demonstrated that a short-acting GLP1Ra known as DMB (2-quinoxalinamine, 6,7-dichloro-N-[1,1-dimethylethyl]-3-[methylsulfonyl]-,6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline or compound 2, Sigma) also mitigates adverse postinfarction left ventricular remodeling and cardiac dysfunction in lean mice through activation of parkin-mediated mitophagy following infarction. Here, we combined proteomics with in silico analysis to characterize the range of effects of DMB in vivo throughout the course of early postinfarction remodeling. We demonstrate that the mitochondrion is a key target of DMB and mitochondrial respiration, oxidative phosphorylation and metabolic processes such as glycolysis and fatty acid beta-oxidation are the main biological processes being regulated by this compound in the heart. Moreover, the overexpression of proteins with hub properties identified by protein–protein interaction networks, such as Atp2a2, may also be important to the mechanism of action of DMB. Data are available via ProteomeXchange with identifier PXD027867.